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Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (Montrer PRKAA1 Protéines)/p38 MAPK (Montrer MAPK14 Protéines)-ERK3 (Montrer MAPK4 Protéines)/mTORC1 pathways. ERK3 (Montrer MAPK4 Protéines) is a newfound potential prognostic predictor and a tumor suppressor in ICC.
Study revealed a post-translational regulation of TDP2 (Montrer TDP2 Protéines) activity and discovered a new role of ERK3 (Montrer MAPK4 Protéines) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (Montrer TOP2A Protéines) inhibitors.
MAPK6 could rescue the cell growth induced by miR499a and HBV
ERK3 (Montrer MAPK4 Protéines) regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3 (Montrer NCOA3 Protéines)/SP-1 (Montrer PSG1 Protéines)-mediated VEGFR2 (Montrer KDR Protéines) expression.
These findings further expand distinct roles of cyclin D3 (Montrer CCND3 Protéines) and suggest the potential activity of ERK3 (Montrer MAPK4 Protéines) in cell proliferation.
Cdc14A (Montrer CDC14A Protéines) forms a stable complex with atypical mitogen-activated protein kinase (Montrer MAPK1 Protéines) Erk3 (Montrer MAPK4 Protéines) in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
identify the Erk3 (Montrer MAPK4 Protéines) protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK (Montrer MAPK1 Protéines) signaling.
A previously unknown role for ERK3 (Montrer MAPK4 Protéines) in promoting lung cancer cell invasiveness by phosphorylating SRC-3 (Montrer NCOA3 Protéines) and regulating SRC-3 (Montrer NCOA3 Protéines) proinvasive activity by site-specific phosphorylation.
ERK3 (Montrer MAPK4 Protéines) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 (Montrer CDKN1A Protéines) but not that of substrates ubiquitinated on internal lysine residues.
ERK3 (Montrer RYK Protéines) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular-regulated kinase 3 (ERK3 (Montrer RYK Protéines)) specifically interacts with the MAPK-activated protein kinase 5 (MK5 (Montrer MAPKAPK5 Protéines) or PRAK (Montrer MAPKAPK5 Protéines)) in vitro and in vivo.
Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5 (Montrer MAPKAPK5 Protéines)).
p38gamma (Montrer MAPK12 Protéines) MAP kinase (Montrer MAPK1 Protéines) (SAPK3/p38gamma (Montrer MAPK12 Protéines)) was shown to catalyse phosphorylation of SAP97 (Montrer DLG1 Protéines).
Results show that Cdo (Montrer CDO1 Protéines) is important for full Abl kinase activity, and Abl (Montrer ABL1 Protéines) is necessary for full activation of p38 MAPK (Montrer MAPK14 Protéines), during myogenic differentiation.
The Arabidopsis MKK4 (Montrer MAP2K4 Protéines)/MKK5 (Montrer MAP2K5 Protéines)-MPK6 cascade is an important player in the maternal control of embryogenesis.
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 (Montrer MAPK3 Protéines) and MPK6, in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (Montrer SPINT1 Protéines), HAI2 (Montrer SPINT2 Protéines), and HAI3 through ABF/AREB transcription factors
Proteome changes associated with MPK4 (Montrer MAPK4 Protéines) and MPK6 deficiency in Arabidopsis roots.
Results suggest that these mutants can be used to analyze the specific biological functions of MAP kinase 6 (MPK6).
These data highlight MPK6 and MKP1 (Montrer DUSP1 Protéines) as components of an L-Glutamate (Montrer GRIN2A Protéines) pathway linking the auxin response, and cell division for primary root growth.
Genetic and biochemical evidences not only show that MEK1 (Montrer MAP2K1 Protéines)-MPK6 cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1 (Montrer MAP2K1 Protéines)-MPK6 cascade functions via working downstream of H2O2 and upstream of NO.
that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF expression and freezing tolerance in plants
BASL polarization leads to elevated nuclear MPK6 signaling and lowered SPCH abundance in one of the two daughter cells. Therefore, two daughter cells are differentiated by BASL polarity-mediated differential suppression of SPCH, which may provide developmental plasticity in plant stem cell asymmetric cell division.
results indicated that AIK1-MKK5 (Montrer MAP2K5 Protéines)-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (Montrer MAPK1 Protéines) cascade.
MPK6 role in ultraviolet induced stomatal closure
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
, MAP kinase 6
, MAP kinase isoform p97
, MAPK 6
, extracellular signal-regulated kinase 3
, extracellular signal-regulated kinase, p97
, protein kinase, mitogen-activated 5
, protein kinase, mitogen-activated 6
, Erk-3 related
, mitogen activated protein kinase 4
, mitogen activated protein kinase 6
, protein kinase, mitogen activated kinase 4
, extracellular related kinase 3
, mitogen-activated protein kinase 6