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anti-Human RAF1 Anticorps:
anti-Rat (Rattus) RAF1 Anticorps:
anti-Mouse (Murine) RAF1 Anticorps:
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Human RAF1 Primary Antibody pour IHC - ABIN966940
Gabriel, Bravery, Dougherty, Kayley, Malster, Scales: Vascular access: indications and implications for patient care. dans Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2005
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Human Polyclonal RAF1 Primary Antibody pour DB, ELISA - ABIN4369727
Gohlke, Kuhn, Case: Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach. dans Proteins 2004
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Virus Polyclonal RAF1 Primary Antibody pour ICC, IF - ABIN4340713
Retallack, Di Lullo, Arias, Knopp, Laurie, Sandoval-Espinosa, Mancia Leon, Krencik, Ullian, Spatazza, Pollen, Mandel-Brehm, Nowakowski, Kriegstein, DeRisi: Zika virus cell tropism in the developing human brain and inhibition by azithromycin. dans Proceedings of the National Academy of Sciences of the United States of America 2016
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Human Monoclonal RAF1 Primary Antibody pour FACS, IHC - ABIN969559
Hofmann, Heinrich, Radziwill, Radziwil, Moelling: A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. dans Molecular cancer research : MCR 2009
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Human Monoclonal RAF1 Primary Antibody pour FACS, IHC - ABIN969560
Takezawa, Okamoto, Yonesaka, Hatashita, Yamada, Fukuoka, Nakagawa: Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. dans Cancer research 2009
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Human Monoclonal RAF1 Primary Antibody pour WB - ABIN260776
Chiloeches, Mason, Marais: S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. dans Molecular and cellular biology 2001
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Human Polyclonal RAF1 Primary Antibody pour DB - ABIN389828
Duan, Cobb: Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. dans Proceedings of the National Academy of Sciences of the United States of America 2010
Human Polyclonal RAF1 Primary Antibody pour IF (p), IHC (p) - ABIN712706
Wu, Dong, Shi, Yu, Fu, Zhang, Cai, Zhao, Peng, Wu, Wu: Regulation of integrin ?V subunit expression by sulfatide in hepatocellular carcinoma cells. dans Journal of lipid research 2013
Human Polyclonal RAF1 Primary Antibody pour IHC, WB - ABIN361884
Dougherty, Müller, Ritt, Zhou, Zhou, Copeland, Conrads, Veenstra, Lu, Morrison: Regulation of Raf-1 by direct feedback phosphorylation. dans Molecular cell 2005
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Human Polyclonal RAF1 Primary Antibody pour IHC, WB - ABIN362494
Fabian, Daar, Morrison: Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. dans Molecular and cellular biology 1993
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Authors evaluated the expression of known targets of miR (Montrer MLXIP Anticorps)-125a and found that sirtuin-7 (Montrer SIRT7 Anticorps), matrix metalloproteinase-11 (Montrer MMP11 Anticorps), and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (Montrer MLXIP Anticorps)-125a.
Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 (Montrer LILRB1 Anticorps) and resulted in a more aggressive oncogenic phenotype, and ciRS-7 overexpression permitted the inhibition of miR-7 (Montrer LILRB1 Anticorps) and subsequent activation of EGFR (Montrer EGFR Anticorps) and RAF1 oncogenes
miR (Montrer MLXIP Anticorps)-497 could serve as a tumor suppressor and a potential early diagnostic marker of gastric cancer by targeting Raf-1 proto-oncogene (Montrer RAB1A Anticorps).
RAF1 may have a role in survival in hepatocellular carcinoma, and indicate whether sorafenib should be used as a postoperative adjuvant
Mutational activation of Kit-, Ras/Raf/Erk (Montrer EPHB2 Anticorps)- and Akt (Montrer AKT1 Anticorps)- pathways indicate the biological importance of these pathways and their components as potential targets for therapy.
Results indicate that des (Montrer DES Anticorps)-gamma-carboxy prothrombin (Montrer F2 Anticorps) (DCP (Montrer ACE Anticorps)) antagonizes the inhibitory effects of Sorafenib on hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) through activation of the Raf/MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps) and PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) signaling pathways.
DiRas3 (Montrer DIRAS3 Anticorps) binds to KSR1 (Montrer KSR1 Anticorps) independently of its interaction with activated Ras and RAF.
RhoA (Montrer RHOA Anticorps)/ROCK and Raf-1/CK2 (Montrer CSNK2A1 Anticorps) pathway are responsible for TNF-alpha (Montrer TNF Anticorps)-mediated endothelial cytotoxicity via regulation of the vimentin (Montrer VIM Anticorps) cytoskeleton.
Although Raf-1 gene is not mutated, an abnormality of Raf-1 kinase feedback regulation enhances its antiapoptotic function, and Raf-1 can still be a pharmaceutical target to increase chemotherapy or radiotherapy sensitivity in these cancer cells.
RAF1 plays a critical role in maintaining the transformed phenotype of CRC cells, including those with mutated KRAS.
cdk10 (Montrer CDK10 Anticorps) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
data suggest that G alpha(i3), Shc (Montrer SHC1 Anticorps), Grb2 (Montrer GRB2 Anticorps), Ras, and Raf-1 link Src (Montrer SRC Anticorps) to activation of MAPK (Montrer MAPK1 Anticorps) and to the AT(2)-dependent increase in eNOS (Montrer NOS3 Anticorps) expression in PAECs
BRAF (Montrer BRAF Anticorps) and ROKalpha (Montrer ROCK2 Anticorps) form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (Montrer EGF Anticorps)).
Mechanistically, BRAF (Montrer BRAF Anticorps) and RAF1 operate independently to balance MAPK (Montrer MAPK1 Anticorps) signaling: BRAF (Montrer BRAF Anticorps) promotes ERK (Montrer EPHB2 Anticorps) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
A- and B-Raf (Montrer SNRPE Anticorps) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (Montrer VEGFA Anticorps) protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (Montrer RPS6KA2 Anticorps) was increased in Raf1(L613V) mice. Constitutive RSK3 (Montrer RPS6KA2 Anticorps) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
C-Raf involves in osteoblast survival in response to mechanical stress.
Dual inhibition of c-Raf and soluble epoxide hydrolase (Montrer EPHX2 Anticorps) by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.
Simultaneous inhibition of sEH (Montrer EPHX2 Anticorps) and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1 (Montrer PDX1 Anticorps)-Cre mice.
under normal physiological conditions, PTEN suppresses AKT (Montrer AKT1 Anticorps) activity to maintain activation of the RAF1/ERK (Montrer EPHB2 Anticorps) signaling pathway, which in turn maintains normal function of the initial segment and therefore, normal sperm maturation.
these data indicate that B-RAF (Montrer SNRPE Anticorps) is an important factor in oncogenic C-RAF-mediated tumorigenesis.
Both c-Raf and B-Raf (Montrer BRAF Anticorps) are required for Ras-induced MEK1 (Montrer MAP2K1 Anticorps) and p42 (Montrer EPB42 Anticorps) MAP kinase (Montrer MAPK1 Anticorps) activation.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
, RAF proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-RAF
, raf proto-oncogene serine/threonine protein kinase
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, v-raf-1 murine leukemia viral oncogene homolog 1
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, RAF proto-oncogene serine/threonine-protein kinase-like
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, Proto-oncogene c-RAF