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Human EGFR Protein expressed in HEK-293 Cells - ABIN6253725
Fazekas-Singer, Berroterán-Infante, Rami-Mark, Dumanic, Matz, Willmann, Andreae, Singer, Wadsak, Mitterhauser, Jensen-Jarolim: Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials. dans Oncotarget 2017
Human EGFR Protein expressed in Human Cells - ABIN2001843
Schlessinger: Cell signaling by receptor tyrosine kinases. dans Cell 2000
Show all 4 Pubmed References
Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000
Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. dans Molecular cancer therapeutics 2014
Human EGFR Protein expressed in Insect cells (Sf9) - ABIN2720019
Chaudhary, Thamake, Shetty, Vishwanatha: Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. dans British journal of cancer 2014
Human EGFR Protein expressed in Wheat germ - ABIN1352437
Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. dans Nature 2013
Human EGFR Protein expressed in HEK-293 Cells - ABIN5674594
Yu, Pegram, Bigner, Chandramohan: Development and validation of a cell-based fluorescent method for measuring antibody affinity. dans Journal of immunological methods 2017
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2).
The somatic EGFR-ERK activity appeared to regulate the termination of Bam expression in the germline and promote subsequent differentiation to the spermatocyte stage.
stress-dependent EGFR/MAPK promotes gut regeneration via a novel mechanism that operates independently of Insulin/Pi3K/TOR signaling.
EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
Graf functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro is antagonized by EGFR signaling, which inhibits Gro-dependent repression via p-ERK mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT/ERK pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Data suggest that OSCP1 (organic solute carrier partner 1) plays multiple roles during eye development in D. melanogaster; OSCP1 regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.
The vector of cell movement is regulated by localised epidermal growth factor (EGF) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation.
Our findings provide in vivo evidence for the role of adult neurons in the maintenance of glia and a novel role for EGFR signaling in the autophagic flux.
Gro inhibits rho expression in undifferentiated cells and represses the expression of both ato and rho in non-R8 precursors during initiation of photoreceptor differentiation in an E(spl)-dependent manner.
strategy for producing ordered square cell packing configurations in epithelia and reveal a molecular mechanism by which organized tissue structure is generated through spatiotemporally regulated responses to EGF receptor activation.
the findings indicate that Vps4 can promote EGFR activity through an endocytosis-independent mechanism.
Drosophila compound eye development is a good model for studying the Egfr signaling pathway.
Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance.
Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
Measurements of circulating DNA within body fluids presented potentially new tools for the disease management of Non-Small-Cell Lung Carcinoma (NSCLC) patients with EGFR mutations. We demonstrated both plasma and urinal DNA correlated well to tissue biopsies and were potentially prognostic to address patients' survival outcome.
Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling
Data show that epidermal growth factor receptor (EGFR) expression positively correlated with the grade of tissue degeneration.
Rescue of HPV16 E6/E7 expression with simultaneous HPV16 E5 knockdown confirmed that E5 plays a key role in EGFR overexpression and EGFR-induced viral invasion.
These studies demonstrate a requirement for human herpesvirus 5 pUL135 interactions with Abi-1 and CIN85 for regulation of EGFR and mechanistically link the regulation of EGFR to virus reactivation.
Adenocarcinoma component harboring the EGFR mutation became dominant in association with disease progression.
A dual specificity phosphatase, DUSP6, that negatively regulates phosphorylation of (P)-ERK is up-regulated in EGFR- or KRAS-mutant lung adenocarcinoma (LUAD), potentially protecting cells with mutations in the RAS signaling pathway, a proposal supported by experiments with DUSP6-specific siRNA and an inhibitory drug
For non-squamous NSCLC patients harboring activating EGFR mutations.
Results show that the rs9642391C>G variant, which is located in the intron region of EGFR, is associated with GBAS expression and survival outcomes in surgically resected early-stage non-small cell lung cancer patients.
Dual EGFR/HER2 knockdown by siRNAs further decreased the growth of Gastric Cancer cells treated with gefitinib alone, confirming that single-agent drug targeting does not achieve a maximal biological effect.
low levels of HIF-1alpha mRNA or EGFR mRNA are negative independent prognostic markers for soft tissue sarcoma patients, especially after combination of both parameters.
Lung adenocarcinoma patients with EGFR-tyrosine kinase inhibitor sensitizing mutations, have a lower mutational burden and do not show a characteristic mutation pattern influenced by smoking.
May be clinically beneficial for patients with EGFR mutation-positive lung adenocarcinoma.
The promising predictive biomarkers for emerging refractory tumors with the EGFR-T790M mutation.
RNF144A promotes EGFR ubiquitination, maintains EGFR protein, and prolongs EGF/EGFR signaling during EGF stimulation.
Studies found EGFR C797S mutation was the major resistance mechanism to EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer patients with original EGFR T790M mutation. [review]
EGFR mutation is associated with good response to chemotherapy in Lung Adenocarcinoma.
FHL2 interacts with EGFR and EGFRvIII to increase their levels and this promotes glioma growth, representing a novel mechanism that may be therapeutically targetable.
Results show that nicotine induced the phosphorylation of EGFR through nAChR in head and neck squamous cell carcinoma (HNSCC). Phosphorylated EGFR was translocated from the cell surface to the nucleus, and activated Akt and mTOR. These signaling pathways elevated the cell activities of HNSCC cells, causing lymph node metastasis and resistance to cetuximab.
Exon 21 EGFR Mutation is associated with Stage III in Non-small Cell Lung Cancer Adenocarcinoma.
High EGFR expression is associated with angiogenesis in B16 melanoma.
Chi3l3 activates EGFR to promote oligodendrogenesis.
Gene deletion of Egfr in myeloid cells limits IL-6 and TNF-alpha production, lipid uptake, and consecutively reduces atherosclerosis development.
Our results identify a key role for NRG1/ErbB signalling in the regulation of hippocampal mGluRI-dependent synaptic and cognitive functions, whose alteration might contribute to the pathogenesis of different brain diseases.
Amphiregulin plays an important role in promoting cardiac fibrosis after myocardial infarction partly though activating the EGFR pathway.
We further show that EGFR is activated through toll-like receptor 4. Disruption of toll-like receptor 4 or the EGFR pathway led to reduced inflammatory activity and foam cell formation
HER2 and HER3 expression was detected in 22.2% and 86.1% of samples, respectively. The frequency of EGFR mutation was 45.7% and was not significantly different between stage 0 and IA1 (40.0% and 48.0%, respectively), suggesting that EGFR mutation does not correlate with cancer progression from stage 0 to IA1.
The results indicate that EGFR and its activation are critical for YAP-mediated suppression of TGF-beta1-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1-mediated simultaneous apoptosis and epithelial mesenchymal transformation.
our findings suggested the concept of the EGFR activated Osteoarthritis (OA) subpopulation and illustrated the mechanism of EGFR signaling in regulating cartilage homeostasis. Gefitinib could be a promising disease-modifying drug for this OA subpopulation treatment.
Cortactin expression in carcinoma cells and its known involvement in the EGFR pathway suggest a role for this protein as a target for laryngeal squamous cell carcinoma therapy.
results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.
Suggest caution for the proposed therapeutic strategy of combined signal transducer and activator of transcription/epidermal growth factor receptor inhibition for cancer treatment with respect to cardiotoxity.
Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation.
miR-145 can decrease MUC5AC expression by inhibiting EGFR and alleviating airway remodeling. This indicates that miR-145 may be used as a molecular predictor for airway remodeling.
To evaluate the role of EGFR signaling in the articular cartilage, we studied a cartilage-specific Egfr-deficient (CKO) mouse model (Col2-Cre EgfrWa5/flox). These mice developed early cartilage degeneration at 6 mo of age. By 2 mo of age, although their gross cartilage morphology appears normal, CKO mice had a drastically reduced number of superficial chondrocytes and decreased lubricant secretion at the surface.
All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.
Using a murine model for glioblastoma driven by a single genetic driver, the study suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness.
These results suggest that EphA2/Efna1/Egfr genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations.
These results collectively suggest that sustained activation of Wnt/beta-catenin signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling.
this study shows that anemonin may ameliorate LPS-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS-derived nitric oxide.
An expressed transition SNP was identified in Meishan and white composite swine breeds.
EGFR, VEGFR and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF and its receptor on the uterine artery and the region supplying these vessels.
This result suggests that ubiquitination of the kinase-impaired receptor can mediate its internalization by the clathrin pathway.
A linear relationship of EGF/EGFR, PI3-kinase, MAPK and geminal vesicle breakdown, presents a relatively definitive mechanism of EGF-induced meiotic resumption of porcine oocyte.
mRNA expression of EGF receptor
EGFR activation, by PKC signal pathway, participates in FSH-induced porcine oocyte meiotic resumption.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (human recombinant EGF) alone or with EGF in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src and PI3K to amplify the oxytocin signaling to increase the output of PGF(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF) and EGF receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF and HGF pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
These results show that MMP-2 activates the EGFR and triggers downstream signaling pathways increasing Reactive Oxygen Species formation and promoting vasoconstriction.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1