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anti-Mouse (Murine) IL1B Anticorps:
anti-Rat (Rattus) IL1B Anticorps:
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Bacteria Polyclonal IL1B Primary Antibody pour ELISA, EM - ABIN269770
Petrovski, Ayna, Majai, Hodrea, Benko, Mádi, Fésüs: Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophages. dans Autophagy 2011
Show all 23 Pubmed References
Human Monoclonal IL1B Primary Antibody pour CyTOF, FACS - ABIN4899223
Yates, Burgess, Kocsis-Angle, Antal, Dority, Embury, Piotrkowski, Brunden: Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. dans Journal of neurochemistry 2000
Show all 15 Pubmed References
Dog (Canine) Polyclonal IL1B Primary Antibody pour IF (p), IHC (p) - ABIN728503
Zhong, Shu, Wang, Luo, Zhong, Ran, Zheng, Yin, Ling: Enhanced homing of mesenchymal stem cells to the ischemic myocardium by ultrasound-targeted microbubble destruction. dans Ultrasonics 2011
Show all 11 Pubmed References
Human Polyclonal IL1B Primary Antibody pour ELISA, ICC - ABIN6262623
Ding, Xu, Wang, Zhang: Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. dans Medical science monitor : international medical journal of experimental and clinical research 2016
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Human Polyclonal IL1B Primary Antibody pour IHC (p), IHC - ABIN446969
Omran, Peng, Zhang, Xiang, Xue, Gan, Kong, Yin: Interleukin-1β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy. dans Epilepsia 2012
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Human Polyclonal IL1B Primary Antibody pour IHC, WB - ABIN6672481
Wu, Zhang, Qi, Zhang, Li, Li, Lin, Bai, Liu, Chen, Yang, Xu, Zhang, Yang: Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. dans Cell death & disease 2018
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Mouse (Murine) Polyclonal IL1B Primary Antibody pour IHC, WB - ABIN3021462
Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes. dans Frontiers in molecular neuroscience 2017
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Mouse (Murine) Polyclonal IL1B Primary Antibody pour Neut, WB - ABIN223538
Scott, Ma, Viriyakosol, Terkeltaub, Liu-Bryan: Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. dans Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Polyclonal IL1B Primary Antibody pour WB - ABIN3042625
Yao, Peng, Peng, Tan, Wu, Wu, Chen, Li, Li, Zhu: Effects of extract of Buddleja officinalis on partial inflammation of lacrimal gland in castrated rabbits with dry eye. dans International journal of ophthalmology 2012
Show all 5 Pubmed References
Rat (Rattus) Polyclonal IL1B Primary Antibody pour ELISA, WB - ABIN3043165
Yu, Chen, Wang, Kuang, Liu, Zhang, Du: Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke. dans PLoS ONE 2013
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Macrophage-less irf8 mutants show prolonged inflammation with elevated levels of Tnf-alpha and Il-1beta.
This study reveals that proper levels of Il1b signaling and tissue inflammation, which are tuned by macrophages, play a crucial role in tissue regeneration.
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase dependent manner.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
findings reveal that the Il-1beta-Myd88 axis and NADPH oxidase-mediated ROS signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
The results suggest that certain species of commensal bacteria in post-weaning mice aggravate ovalbumin-induced allergic asthma through NLRP3/IL1B signal pathway.
Ferrylhemoglobin is a potent trigger of NLRP3 activation and production of IL-1beta in vitro and in vivo.
mitochondrial IL-1beta production by bone marrow-derived macrophages was significantly reduced in ATF3 KO mice as a result of the disruption of cellular ROS and Ca(2+) homeostasis. Accordingly, ATF3 KO mice displayed diminished survival and bacterial clearance following S. pneumoniae infection.
Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1beta. Neutrophil extravasation was mediated by MyD88-dependent IL-1beta production by graft-infiltrating classical monocytes, which downregulated the expression of the tight junction-associated protein ZO-2 in pulmonary vascular endothelial cells.
These findings reveal a novel mechanism of acute hyperglycemia postburn in which impaired insulin secretory capacity mediated by IL-1beta leads to acute hyperglycemia.
Investigation of 2-AP demonstrated its nociception inhibition and ability to reduce reactive oxygen species. Its interaction with A2a receptors may well be related to proinflammatory cytokines TNF-alpha and IL-1beta reduction activity, corroborating its antinociceptive effect.
The data of this study presented here indicates that TGFbeta1 plays a role in the pathogenesis of hepatic encephalpoathy by inducing microglia activation and neuroinflammation.
These results suggest that an IL-1beta activation pathway, different from NLRP3 inflammasomes, plays an important role in pressure overload-induced sustained atrial fibrillation.
these findings reveal unexpected regulation of IL-1beta production by neutrophils in response to pathogenic fungi
IL-1 alpha/beta plays a positive role in muscle regeneration by coordinating the initial interactions among inflammatory microenvironments and satellite cells.
Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1beta and IL-17A.
Description of a previously unknown link between the endocannabinoid system and interleukin-1beta in the context of Alzheimer's disease.
IL-1beta-induced pulmonary inflammation in early life causes a chronic lung disease in adulthood.
vitamin D suppresses lipopolysaccharide-induced HIF-1alpha to block IFNgamma and IL-1beta productions.
These results suggest that glucose supplied from blood vessels might be important for IL-1beta production in tumor-associated macrophages via the integrated signals of the NF-kappaB and mTOR pathways in the tumor microenvironment.
IL-1beta has multiple beneficial effects in late-stage murine atherosclerosis.
IL-1beta inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization.
Data suggest that microglia relied on caspase recruitment domain-containing protein 9 (CARD9) for production of interleukin-1beta (IL-1beta), inflammasome activation and of chemokine CXCL1 (CXCL1) in the fungus-infected central nervous system (CNS).
Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production.
interaction between Mincle and SAP130 may promote the progression of alcoholic liver disease by IL-1beta production in Kupffer cells and consequently increase inflammatory immune cell infiltration.
IL1B promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells and the cell's stem-like properties through PI3K pathway.
Findings from this study suggest that IL-1beta induces apoptosis in annulus fibrosus cells through the ERK pathway, and therefore, ERK inhibition may provide certain protection against the adverse effects of IL-1beta.
production of IL1beta in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c(+) myeloid cells
These results elucidate the role of KLF4 in antagonizing the effect of IL-1beta in human chondrocytes under 2 dyn/cm(2) shear force stimulation and provide a possible mechanism to demonstrate the protection of moderate forces or exercises in cartilage.
In oral cancer specimens, CCL22 mRNA was upregulated. Release of IL-1beta from cancer-associated fibroblasts (CAF) induces CCL22 mRNA expression in oral cancer cells by activating NF-kappaB. Data support a model in which CAF-derived IL-1beta, CCL22, and its receptor CCR4 foster a protumor environment by promoting cell transformation and Treg infiltration.
REVIEW: Interleukin-1beta in Post-Traumatic Stress Disorder: Evidence from Human and Animal Studies
research describes a mechanism by which ZFP91 promotes production of IL-1beta under physiological conditions and suggests that ZFP91 may be a promising therapeutic target for intervention in inflammatory, infectious and autoimmune-related diseases
NGF release by epithelial cells was affected by IL1B, suggesting that inflammation has a negative effect on cultured cells.
Proinflammatory interleukin 1 (IL-1(+)) genotypes modulate the risk of Lp(a) long-term cardiovascular disease (CVD) events and coronary artery disease (CAD).
There was a negative association between cannabis use and IL-1beta.
The meta-analysis suggested that the mutation of IL-1beta(-511C/T) in Europe and IL-1beta(+3954C/T) in America tend to increase the risk of RAS, but the polymorphism of IL-10(-1082G/A) appears to have no association with RAS risk in America.
The IL-1B +3954 C > T polymorphism is associated with decreased sepsis risk in Caucasians.[meta-analysis]
The significant increase in IL1B serum level in the type 2 diabetes mellitus Saudi patients. No significant association was observed in the IL1B gene at the -511C/T and -31C/T positions in the type 2 diabetes mellitus Saudi patients.
Interleukin (IL)-6 and IL-1beta are pro-inflammatory cytokines, and SNP in their genes have been shown to interact with dietary, plasma and erythrocyte, fatty acids to influence MetS traits.
In summary, our study reveals a novel mechanism for the reprogramming of renal SCs by IL-1b toward an aerobic glycolysis and the support of fibrogenic activity during kidney injury and fibrosis.
IL-1beta and IL-33 may contribute to the development of systemic sclerosis
Our data suggest that serum IL-18 and IL-1beta have different clinical implications in SLE, with IL-18 being potentially associated with active renal disease.
our current work demonstrates that IL-1beta release from stimulated THP1 cells is regulated by GSDM-D, and P2X7 is a dual-step process
The relative expression of IL1B and CCL2 was higher in coronary artery disease patients than in normal controls.
These studies showed that classical swine fever virus-induced IL-1beta secretion was mediated by NLRP3 and that classical swine fever virus infection could sufficiently activate the assembly of the NLRP3 inflammasome in monocytes.
Hsp90/Sec22b promotes the unconventional secretion of IL-1beta through an autophagosomal carrier during Mycoplasma hyopneumoniae infection.
Data indicated that Porcine reproductive and respiratory syndrome virus infection could induce IL-1beta up-regulation, which was likely mediated by MyD88/ERK/AP-1 and NLRP3 inflammasome.
Analysis of host-protein interactions for African swine fever virus L83L identified IL-1beta as its host ligand. A recombinant African swine fever virus lacking the L83L was developed from the highly virulent field isolate Georgia2007 and was used to show that L83L is a non-essential gene.
This study showed that the presence of embryos in oviducts on days 2-3 after mating may influence the oviductal expression of the members of the IL-1beta system, determining the action of IL-1beta, which may be considered to be the earliest sign of pregnancy in pigs.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
local expression of IL-1beta and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
IL1B regulates expression of IL1R1 and IL1RAP and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri-implantation period of pregnancy in pigs.
the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.
Mycobacterium bovis infected animals have a higher frequency of IFN-gamma producing CD4(+) T cells and elevated plasma IL-1beta levels.
The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 protein and IL1B and IL1R1 mRNA were detected.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.
Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF(2alpha) and PGE(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
Lipopolysaccharide stimulation up-regulates the secretion of cytokines by bovine polymorphonuclear neutrophil leukocytes.
dynamic compression stimulates cell proliferation and proteoglycan synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways
These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.
the low friction of articular cartilage can be modified by TGF-beta1 and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness
These results suggest that IL-1alpha and IL-1beta are produced by the stromal cells, that IL-1beta is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen activator in bovine endometrial cells.
Data suggest an important regulatory mechanism of interleukin-1beta production, associated with microglial migration and proliferation, driven by ECM degradation and/or synthesis in an injured brain.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 in rabbit cornea cells.
IL-1beta and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha.
IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.
The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1, which delays the development of osteoarthritis.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1
Increased PGE2 production led to reduction in 5-LO products in LPS-treated equine whole blood via IL-1b.
Results suggested that chemokine expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
IL-1beta-induced up-regulation of matrix metalloproteinase 13 mRNA was blocked by all concentrations of geldanamycin tested
This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.
The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
, IL-1 beta
, interleukin-1 beta
, preinterleukin 1 beta
, prointerleukin-1 beta
, Interleukin-1 beta
, precursor interleukin-1beta
, interleukin-1 beta proprotein
, interleukin 1 beta
, lymphocyte proliferation-potentiating factor