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Data indicate the association between genetic polymorphisms of interleukin 1 receptor type 1 (IL1R1) and interleukin 1 receptor type 2 (IL1R2) and tuberculosis (TB) susceptibility in the Chinese Han population. IL1R1 and IL1R2 and TB susceptibility in the Chinese Han population.
this study shows that sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients
rs10490571 and rs3917225 were significantly associated with the risk of femur head osteonecrosis in the Chinese Han population.
The finding that the informative microsatellite marker within intron 1 of IL1R detects a survival advantage for patients with cystic fibrosis (CF), revealed through a transmission disequilibrium in patient cohorts with a survivor-dependent recruitment bias, supports involvement of IL-1R in CF pathogenesis.
Two miRNAs, hsa-miR-205-3p and hsa-miR-3909 and their target genes IL-1beta and IL1R1 are specifically involved in the progression of rheumatic heart disease.
IL-1R signaling licenses effector cytokine production by memory CD4 T cells
interleukin-1 receptor 1/MyD88 signalling has roles in the development and progression of pulmonary hypertension
Study highlights the association of genetic polymorphisms of IL1R1 with knee osteoarthritis susceptibility in the Northwestern Chinese Han population.
Serum ST2 is elevated in heart failure patients and correlated with disease severity.
the IL-1 receptor is translocated to lipid rafts where receptor endocytosis occurs to enable the internalization-dependent IL-1 signaling to activate the IL-1-induced gene expression.
Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1), RIP1, and IRAK1, we hypothesize that SH exerts its NF-kappaB activation inhibitory function by interacting with TNFR1, interleukin-1 receptor type 1 (IL-1R1), and TLR3 complexes in the plasma membrane of infected cells.
salt-inducible kinase inhibition decreases proinflammatory cytokines in human myeloid cells upon IL-1R stimulation.
study confirmed that genetic variant in IL-1R1(rs3917267) has significant association with HBV infection and HBV breakthrough infection in children, which provides new clues for the study of pathogenesis of chronic HBV infection in children
ligand-activation of GPER generates a feedforward loop coupling IL1beta induction by CAFs to IL1R1 expression by cancer cells, promoting the up-regulation of IL1beta/IL1R1 target genes such as PTGES, COX2, RAGE and ABCG2
this study shows that IL-1a gene variants are not associated with susceptibility to juvenile idiopathic arthritis in Iranian population
The work identifies a pathogenic role of postnatal IL1b/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged febrile seizures, and highlights IL-1R1 as a potential therapeutic target for preventing the development of epilepsy after infantile febrile seizures.
The results present identification of critical regions within the TIR domain of IL-1 receptor type in humans and mice.
IL1R1 SNP rs949963 is associated with the susceptibility to asthma in children from Central China and may increase the serum expression of IL1R1.
Altered expression of EP2 in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta to increase COX-2 and mPGES-1 expression, which results in low PGE2 production
investigated the association between four inflammatory cytokines (CD121a, interleukin [IL]-1beta, IL-8, and IL-11) and coronary heart disease
IL-1R1 in hepatocytes plays a pivotal role in an IL-1-driven auto-amplification of cell death and inflammation in the onset of acute liver failure.
Findings indicate the structure and functions of the brain's IL-1 receptor 1 (IL-1R1)-expressing system.
this study shows that IL1R1 promotes mobilization of pulmonary dendritic cells during beryllium sensitization
overexpressed miR-495 directly promotes proliferation while simultaneously inhibiting apoptosis of femoral vein (FV) tissues endothelial cells, alleviating FV thrombosis by inhibiting IL1R1 via suppression of TLR4 signaling pathway.
IL-1R1 activation exacerbates cisplatin-induced acute kidney injury by inducing TNF production, thereby augmenting inflammatory signals between kidney parenchymal cells and infiltrating myeloid cells.
IL-1R1-mediated host resistance to M. tuberculosis infection does not involve mechanisms of cell-autonomous antimicrobicidal effector functions in phagocytes but requires the cooperation between infected cells and other cells of hematopoietic or nonhematopoietic origin to promote bacterial containment and control of infection.
IL-1R promotes glucose homeostasis by suppressing expression of Aldh1a3 and sustaining MafA abundance.
Both IL1R and MyD88 signalling in CD4+ T cells promote Th17 immunity, atherosclerotic plaque growth and may regulate plaque collagen levels.
IL1R1 is a gatekeeper for celastrol's metabolic actions.
The H7N9 influenza A virus infection results in lethal inflammation in the mammalian host via the NLRP3-Casp1- IL1R1-expressing inflammasomes.
The present study demonstrates a novel mechanism underlying LPS-induced innate immunity; that is, a secondary upregulation of IL-1beta-IL-1RI signaling is responsible for alveolar macrophages pyroptosis and augmented lung injury in response to LPS.
Study conclude that while interleukin-1 signaling is not critical for lipopolysaccharide induced anorexia or stress hormone release, interleukin-1 type 1 receptor expressed on brain endothelial cells, contributes to the febrile response to lipopolysaccharide.
Data indicate that IL-1RI and TNF-1R contribute to regulation of stress-induced, negatively reinforced drinking perhaps through overlapping signaling events downstream of these receptors, while leaving rewarding properties of alcohol largely unaffected.
These results suggest that cytokines, particularly IL-1, areassociated with pulmonary anti-influenza immune response and inflammatory lung injury, particularly via the influence on neutrophil mobilization and inflammatory cytokine/chemokine production.
Using respective knockout mice it was found that LPS-mediated GIP secretion was selectively dependent on IL-1 signalling.
Results demonstrated the essential role of IL-1R1 in kindling-induced sleep disturbance by using transgenic IL-1R1 KO mice. Epilepsy-induced sleep disturbances were absent in the IL-1R1 KO mice, indicating the importance of IL-1 signals. The knockout of IL-1R1 did not change the seizure thresholds, suggesting that IL-1R1 signaling is not in involved in the kindling-induced epileptogenesis.
findings show elements of the IL-1 network, including IL-1alpha, IL-1beta, and IL-1R1, are essential for the optimal host response to VACV cutaneous infection
These data show that the normal distribution of surface glycosylation requires IL-1R, but not MyD88, and is not sufficient to prevent bacterial binding.
Study provides direct evidence that IL-1R1 is a potent target for adjunctive control of diazepam refractory status epilepticus in mice. Both pharmacological block and gene KO of IL-1R1 may reverse or prevent the progressive diazepam-refractoriness of status epilepticus in mice. Thus, combination of IL-1R1 antagonists with diazepam may be a novel strategy for the treatment of refractory prolonged status epilepticus.
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
CD121 antigen-like family member A
, antigen CD121a
, interleukin 1 receptor alpha, type I
, interleukin receptor 1
, interleukin-1 receptor alpha
, interleukin-1 receptor type 1
, interleukin-1 receptor type I
, IL-1 receptor alpha chain
, interleukin 1 beta receptor type 1 short transmembrane form
, interleukin 1 beta receptor type 1 soluble form
, interleukin 1 bete receptor type 1 long transmembrane form