Aperçu des produits pour anti-IRAK4 (IRAK4) Anticorps

Full name:: anti-Interleukin-1 Receptor-Associated Kinase 4 Anticorps (IRAK4)

Chez www.anticorps-enligne.fr sont 214 Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Anticorps de 30 de différents fournisseurs disponibles. De plus, nous expédions IRAK4 Protéines (14) et IRAK4 Kits (11) et beaucoup plus de produits pour cette protéine. Un total de 249 IRAK4 produits sont actuellement listés.

Synonymes:: 8430405M07Rik, 9330209D03Rik, IPD1, IRAK-4, irak4, ny-ran-64, NY-REN-64, REN64, zgc:55553

afficher tous les anticorps	Gène	GeneID	UniProt
	IRAK4	51135	Q9NWZ3
	IRAK4	266632	Q8R4K2
	IRAK4	300177
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Human Monoclonal IRAK4 Primary Antibody pour ICS - ABIN1176905 : Hatao, Muroi, Hiki, Ogawa, Mimura, Kaminishi, Tanamoto: Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein. dans Journal of leukocyte biology 2004 (PubMed)
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Human Monoclonal IRAK4 Primary Antibody pour ICS - ABIN1176904 : Suzuki, Saito: IRAK-4--a shared NF-kappaB activator in innate and acquired immunity. dans Trends in immunology 2006 (PubMed)
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Human Monoclonal IRAK4 Primary Antibody pour FACS, IHC - ABIN969218 : Pathak, De Souza, Salte, Wiker, Asjö: HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells. dans Scandinavian journal of immunology 2009 (PubMed)
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Human Polyclonal IRAK4 Primary Antibody pour IHC (fro), WB - ABIN2475135 : Linder, Sziegoleit, Brattström, Tydén, Groth: Pancreatic elastase 1 after pancreatic transplantation. dans Pancreas 1991 (PubMed)
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Chimpanzee Polyclonal IRAK4 Primary Antibody pour ELISA, WB - ABIN2475134 : Suzuki, Suzuki, Yeh: IRAK-4 as the central TIR signaling mediator in innate immunity. dans Trends in immunology 2002 (PubMed)
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Human Polyclonal IRAK4 Primary Antibody pour WB - ABIN656802 : Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: Dengue hemorrhagic fever is associated with polymorphisms in JAK1. dans European journal of human genetics : EJHG 2010 (PubMed)
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Human Polyclonal IRAK4 Primary Antibody pour ELISA, IHC (p) - ABIN250402 : Lye, Mirtsos, Suzuki, Suzuki, Yeh: The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. dans The Journal of biological chemistry 2004 (PubMed)

Plus d’anticorps contre IRAK4 partenaires d’interaction

Human Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) interaction partners

IRAK-4 Arg12 is also essential for Myddosome assembly and signalling and we propose that phosphorylated Ser8 induces the N-terminal loop to fold into an alpha-helix. This conformer is stabilised by an electrostatic interaction between phospho-Ser8 and Arg12 and would destabilise a critical interface between IRAK-4 and MyD88 (Montrer MYD88 Anticorps).
Our data established IRAK4 as a novel therapeutic target for PDAC treatment. Development of potent IRAK4 inhibitors is needed for clinical testing.
Data suggest that IRAK4 activity regulates activation of IRF5 (Montrer IRF5 Anticorps), TAK1 (Montrer MAP3K7 Anticorps), and IKKB (Montrer IKBKB Anticorps) in monocytes; IRAK4 activation of TAK1 (Montrer MAP3K7 Anticorps)-IKKB (Montrer IKBKB Anticorps)-IRF5 (Montrer IRF5 Anticorps) axis leads to induction of cytokines and interferons following TLR7 (Montrer TLR7 Anticorps)/TLR8 (Montrer TLR8 Anticorps) stimulation. (IRAK4 = interleukin-1 receptor-associated kinase 4; IRF5 (Montrer IRF5 Anticorps) = interferon regulatory factor-5 (Montrer IRF5 Anticorps); TAK1 (Montrer MAP3K7 Anticorps) = MAPK (Montrer MAPK1 Anticorps) kinase kinase 7; IKKB (Montrer IKBKB Anticorps) = I-kappa B kinase; TLR = toll (Montrer TLR4 Anticorps)-like receptor)
AMPK (Montrer PRKAA1 Anticorps) activation inhibited IL-1beta (Montrer IL1B Anticorps)-stimulated CXCL10 (Montrer CXCL10 Anticorps) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4) phosphorylation.
By CRISPR/Cas9-induced inactivation of TLR9 (Montrer TLR9 Anticorps), MyD88 (Montrer MYD88 Anticorps), IRAK4 and IRAK1 (Montrer IRAK1 Anticorps) we confirm that BZLF1 repression is dependent on functional TLR9 (Montrer TLR9 Anticorps) and MyD88 (Montrer MYD88 Anticorps) signaling, and identify IRAK4 as an essential element for TLR9 (Montrer TLR9 Anticorps)-induced repression of BZLF1 expression upon BCR (Montrer BCR Anticorps) cross-linking
the polymorphisms in TLR-MyD88 (Montrer MYD88 Anticorps)-NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
data show that in pericytes, MyD88 (Montrer MYD88 Anticorps) and IRAK4 are key regulators of 2 major injury responses: inflammatory and fibrogenic.
Data suggest that, in monocytes and macrophages, the interleukin-1B- (IL1B (Montrer IL1B Anticorps))-stimulated trans-autophosphorylation of IRAK4 is initiated by MYD88- (myeloid differentiation primary response gene 88 (Montrer MYD88 Anticorps))-induced dimerization of IRAK4. In contrast, IRAK1 (interleukin-1 receptor-associated kinase 1 (Montrer IRAK1 Anticorps)) is inactive in unstimulated monocytes/macrophages and is converted to an active protein kinase (Montrer CDK7 Anticorps) in response to IL1B (Montrer IL1B Anticorps).
IRAK4 - Gene involved in innate immunity that have been associated with Chronic Rhinosinusitis.
The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95%) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed.

Mouse (Murine) Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) interaction partners

AMPK (Montrer PRKAA1 Anticorps) activation inhibited IL-1beta (Montrer IL1B Anticorps)-stimulated CXCL10 (Montrer CXCL10 Anticorps) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4) phosphorylation.
data show that in pericytes, MyD88 (Montrer MYD88 Anticorps) and IRAK4 are key regulators of 2 major injury responses: inflammatory and fibrogenic.
IRAK4 kinase activity contributes to murine lupus and could represent a new therapeutic target.
Data demonstrate that IRAK-4 is essential for innate and adaptive immunity and necessary for efficient control of mycobacterial infections.
Suppression of IRAK1 (Montrer IRAK1 Anticorps) or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 (Montrer TNIP1 Anticorps)
PMA treatment during a vulnerable period can alter brain development. IL-18 and IRAK-4 appear to be important for the development of PMA induced injury.
enforced expression of miR (Montrer MLXIP Anticorps)-302b or IRAK4 siRNA silencing inhibits downstream NF-kappaB (Montrer NFKB1 Anticorps) signalling and airway leukocyte infiltration, thereby alleviating lung injury and increasing survival in P. aeruginosa-infected mice.
Our results demonstrate that osteoclasts and FBGCs are reciprocally regulated and identify IRAK4 as a potential therapeutic target to inhibit stimulated osteoclastogenesis and rescue inhibited FBGC formation
Suggest FC-99 is a potential therapeutic molecule that alleviated experimental sepsis by directly inhibiting IRAK4 activation.
MiR (Montrer MLXIP Anticorps)-93 inhibits IRAK4 expression by binding directly to the 3'-UTR (Montrer UTS2R Anticorps) of IRAK4.

IRAK4 profil antigène

Antigen Summary

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with IRAK4

interleukin 1 receptor associated kinase 4 (IRAK4) anticorps
interleukin 1 receptor associated kinase 4 (irak4) anticorps
interleukin-1 receptor-associated kinase 4 (irak4) anticorps
interleukin-1 receptor-associated kinase 4 (Irak4) anticorps

8430405M07Rik anticorps
9330209D03Rik anticorps
IPD1 anticorps
IRAK-4 anticorps
irak4 anticorps
ny-ran-64 anticorps
NY-REN-64 anticorps
REN64 anticorps
zgc:55553 anticorps

Protein level used designations for IRAK4

interleukin-1 receptor-associated kinase 4 , interleukin-1 receptor-associated kinase 4-like , Interleukin-1 receptor-associated kinase 4 , renal carcinoma antigen NY-REN-64 , NY-REN-64 antigen , interleukin-1 receptor associated kinase 4

GENE ID	SPECIES
100054848	Equus caballus
100216438	Ovis aries
100019202	Monodelphis domestica
100447243	Pongo abelii
100469127	Ailuropoda melanoleuca
100528915	Ictalurus punctatus
393132	Danio rerio
417796	Gallus gallus
700568	Macaca mulatta
733738	Xenopus (Silurana) tropicalis
100196744	Salmo salar
100227974	Taeniopygia guttata
100402978	Callithrix jacchus
100602648	Nomascus leucogenys
51135	Homo sapiens
266632	Mus musculus
466962	Pan troglodytes
486601	Canis lupus familiaris
100127166	Sus scrofa
533692	Bos taurus
300177	Rattus norvegicus
100341605	Oryctolagus cuniculus

Fournisseurs de qualité sélectionnés pour anti-IRAK4 (IRAK4) Anticorps

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Show all anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Anticorps with Pubmed References

Human Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) interaction partners

Mouse (Murine) Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) interaction partners

Antigen Summary

Alternative names and synonyms associated with IRAK4

Protein level used designations for IRAK4