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anti-Mouse (Murine) NFKBIB Anticorps:
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Human Monoclonal NFKBIB Primary Antibody pour ELISA, WB - ABIN969314
Chen, Vallee, Wu, Vu, Sondek, Ghosh: Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. dans Molecular and cellular biology 2004
Show all 3 Pubmed References
IkappaBbeta has essential functions within the Rel-NFkappaB generation module, specifically for the RelA:RelA homodimer, which controls a subset of NFkappaB target genes.
these results mechanistically link the innate immune response mediated by IkappaBbeta/NF-kappaB (Montrer NFKB1 Anticorps) to ET-1 (Montrer EDN1 Anticorps) expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock.
Dengue virus protease interacts with both IkappaBalpha (Montrer NFKBIA Anticorps) and IkappaBbeta cleaving them in a mouse hemorrhage model.
sustained NF-kappaB (Montrer NFKB1 Anticorps) activity mediated by IkappaBbeta protects against hyperoxic lung injury through increased expression of antiapoptotic genes
Findings represent a necessary but not sufficient role of IkappaBbeta in preventing oxidant stress-induced cell death.
IkappaBbeta is an essential co-activator for LPS (Montrer TLR4 Anticorps)-induced IL-1beta (Montrer IL1B Anticorps) transcription in vivo.
IkappaBbeta acts through p65 (Montrer NFkBP65 Anticorps):c-Rel (Montrer NFkBP65 Anticorps) dimers to maintain prolonged expression of TNF-alpha (Montrer TNF Anticorps)
data suggest that RelA (Montrer NFkBP65 Anticorps) is liberated during LPS (Montrer TLR4 Anticorps)-induced pulmonary inflammation by the regulated degradation of both IkappaB-alpha (Montrer NFKBIA Anticorps) and IkappaB-beta
temporal control of NF-kappaB (Montrer NFKB1 Anticorps) activation by the coordinated degradation and synthesis of IkappaB proteins
beta-TrCP1 (Montrer BTRC Anticorps) contributes to, but is not absolutely required for, the degradation of I kappa B and beta-catenin (Montrer CTNNB1 Anticorps)
The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib.
data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB (Montrer NFKB1 Anticorps).
our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC (Montrer NPC1 Anticorps) via the NF-kappaB (Montrer NFKB1 Anticorps) signalling pathway.
IkappaBbeta may be a novel target for transcription factors of the HMG (Montrer SSRP1 Anticorps)-box SRY (Montrer SRY Anticorps)/Sox (Montrer PIPOX Anticorps) family and imply a potential role for NF-kappaB (Montrer NFKB1 Anticorps)/IkappaBbeta in spermatogenesis
Data show that increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa (Montrer NFKBIA Anticorps), IkBb-1 and IkBb-2.
VEGF (Montrer VEGFA Anticorps) increased Mn-superoxide dismutase (Montrer SOD2 Anticorps) promoter activity, an effect that was dependent on a second intronic NF-kappaB (Montrer NFKB1 Anticorps) consensus motif.
data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta (Montrer IKBKB Anticorps)
None of the NFKBIB SNPs are associated with pneumococcal susceptibility.
NF-kappaB (Montrer NFKB1 Anticorps), IkappaB-alpha (Montrer NFKBIA Anticorps), IkappaB-beta mRNA decreased significantly after weight loss.
increased I-kappaBbeta expression reversed NF-kappaB (Montrer NFKB1 Anticorps) activation in cancer cells, compensating for the loss of I-kappaBalpha (Montrer NFKBIA Anticorps) via TGase 2 (Montrer TGM2 Anticorps) polymerization.
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
, NF-kappa-B inhibitor beta
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta
, TR-interacting protein 9
, thyroid receptor-interacting protein 9