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Human Monoclonal NFKBIB Primary Antibody pour ELISA, WB - ABIN969314
Chen, Vallee, Wu, Vu, Sondek, Ghosh: Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. dans Molecular and cellular biology 2004
Show all 3 Pubmed References
The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib.
data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB.
our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway.
NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing.
IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis
Data show that increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2.
VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif.
data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta
None of the NFKBIB SNPs are associated with pneumococcal susceptibility.
NF-kappaB, IkappaB-alpha, IkappaB-beta mRNA decreased significantly after weight loss.
increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization.
NFKBIA and NFKBIB are not likely to harbor ovarian cancer risk alleles.
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
, NF-kappa-B inhibitor beta
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta
, TR-interacting protein 9
, thyroid receptor-interacting protein 9