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The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50.
The data imply that regulation of these c-Rel-dependent lymphoid responses is a non-redundant function of IkappaBepsilon.
temporal control of NF-kappaB activation by the coordinated degradation and synthesis of IkappaB proteins
IkappaBepsilon deficiency in mice leads to neonatal death, elevated kappaB binding activity, overexpression of NF-kappaB target genes, and disruption of lymphocyte production.
Neither IkappaBalpha nor IkappaBepsilon deficiency had major effects on natural killer cell generation while their combined absence led to NF-kappaB hyperactivation.
An important role is proposed for I kappa B epsilon in the differential regulation of nuclear NF-kappa B activity in stimulated B cells.
In vivo degradation rate constants were measured for NF-kappaB-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL.
We suggest that the impairment of NFKBIE gene function can reduce the uptake of methotrexate into cells, suggesting that the gene is an important factor for rheumatoid arthritis outcome
A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis.
results show that Gal-1 acts by inhibiting the stimulation of the LPS-induced IkappaBzeta expression, an NF-kappaB regulator involved in IL-6 gene transcription.
Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-kappaB inhibitor varepsilon (IkappaBvarepsilon), in 14.5% of samples of desmoplastic melanoma
IkappaBepsilon has a role in NF-kappaB regulation in aggressive chronic lymphocytic leukemia
Vitamin C forestalls cigarette smoke induced NF-kappaB activation in alveolar epithelial cells.
we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon
An NFKBIE SNP associated with susceptibility to pneumococcal disease but not pneumococcal empyema.
Expression levels of GGT1 and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite.
Genomic mutation of the NFKBIE gene in primary Hodgkin/ Reed Sternberg cells
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
, NF-kappa-B inhibitor epsilon
, solute carrier family 35, member B2