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Human Polyclonal PKC zeta Primary Antibody pour ICC, IF - ABIN4345863
Verbist, Guy, Milasta, Liedmann, Kamiński, Wang, Green: Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. dans Nature 2016
Human Polyclonal PKC zeta Primary Antibody pour IHC (p) - ABIN2476259
Hirai, Chida: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. dans Journal of biochemistry 2003
Human Polyclonal PKC zeta Primary Antibody pour IHC (p), WB - ABIN391018
Lerner-Marmarosh, Miralem, Gibbs, Maines: Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Protein kinase c (Montrer PKC Anticorps) activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
PKCzeta promoted lung adenocarcinoma invasion and metastasis, and its expression was associated with MMP2 (Montrer MMP2 Anticorps) and MMP9 (Montrer MMP9 Anticorps) expression.
PKC-zeta may be responsible for the abnormal growth, proliferation, and migration of metastatic LOVO colon cancer cells via PKC-zeta/Rac1/Pak1 (Montrer PAK1 Anticorps)/beta-Catenin (Montrer CTNNB1 Anticorps) pathway.
reduced expression of PKCzeta/Pard3 (Montrer PARD3 Anticorps)/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine (Montrer SGMS2 Anticorps) remarkably attenuated gut (Montrer GUSB Anticorps) injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2 (Montrer TRAF2 Anticorps), which was phosphorylated by PKCzeta at Ser (Montrer SIGLEC1 Anticorps)(55), but not at Ser (Montrer SIGLEC1 Anticorps)(11), under intestinal I/R or H/R conditions
these results conclude that miR (Montrer MLXIP Anticorps)-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK (Montrer PRKAA1 Anticorps) signaling.
PKCzeta was specifically involved in ACOT7 (Montrer ACOT7 Anticorps) depletion-mediated cell cycle arrest as an upstream molecule of the p53 (Montrer TP53 Anticorps)-p21 (Montrer CDKN1A Anticorps) signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
we found that Wnt3a (Montrer WNT3A Anticorps) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (Montrer DVL2 Anticorps) and Dvl3 (Montrer DVL3 Anticorps). Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl (Montrer DVL2 Anticorps) signaling activity, to produce a strong and sustained response to Wnt3a (Montrer WNT3A Anticorps) treatment by stabilizing Dvl (Montrer DVL2 Anticorps) protein levels.
The data demonstrate that PKCzeta expression regulates the maturation of neonatal T-cells into specific functional phenotypes and that environmental influences may work via PKCzeta to regulate these phenotypes and disease susceptibility.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (Montrer GPR39 Anticorps) to enhance the abundance of ZO-1 (Montrer TJP1 Anticorps), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 (Montrer IL4 Anticorps) and interleukin-10 (Montrer IL10 Anticorps)
HIF regulation of HOIL-1L (Montrer RBCK1 Anticorps) targets the phosphorylated PKC-zeta for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase (Montrer ATP1A1 Anticorps), avoiding significant lung injury.
Under physiological conditions, PKMzeta is the principal PKC (Montrer PKC Anticorps) isoform that maintains LTP (Montrer SCP2 Anticorps) and long-term memory. PKCiota/lambda can compensate for PKMzeta, and because other isoforms could also maintain synaptic facilitation, there may be a hierarchy of compensatory mechanisms maintaining memory if PKMzeta malfunctions. [Review]
aPKCzeta is required for the cellular organization of acto-non-muscle myosin II (NMII) cytoskeleton, for proper cell adhesion and directed cell migration.
This study demonstrates that the combination therapy of PKCzeta and COX-2 (Montrer COX2 Anticorps) inhibitors can significantly inhibit melanoma metastasis in vitro and in vivo, which will be an efficient strategy for treatment of melanoma metastasis in clinics
the inhibition of PKCzeta or ceramide synthesis did not further improve glucose tolerance in Angptl4 (Montrer ANGPTL4 Anticorps)(-/-) mice, suggesting that these molecules were major downstream effectors of Angptl4 (Montrer ANGPTL4 Anticorps).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 (Montrer SP1 Anticorps) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
APPL1 (Montrer APPL1 Anticorps) enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A (Montrer PPP2R2B Anticorps) and myosin IIa.
Findings indicate PDZRN3 (Montrer PDZRN3 Anticorps) regulates vascular permeability through a PKCzeta-containing complex.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (Montrer INS Anticorps) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (Montrer FRAP1 Anticorps) protein) and Ccnd2 (cyclin-D2 (Montrer CCND2 Anticorps)).
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (Montrer ANGPT1 Anticorps), via phosphorylation of eNOS (Montrer NOS3 Anticorps) on Thr (Montrer TRH Anticorps)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (Montrer VEGFA Anticorps)-stimulated endothelial permeability by Ang-1 (Montrer ANGPT1 Anticorps).
ceramide as a potent physiological modulator of the Na(+)-ATPase (Montrer DNAH8 Anticorps), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta