Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Human PRKACA Anticorps:
anti-Rat (Rattus) PRKACA Anticorps:
anti-Mouse (Murine) PRKACA Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Human Polyclonal PRKACA Primary Antibody pour ICC, IF - ABIN408069
Enns, Morton, Mangalindan, McKnight, Schwartz, Kaeberlein, Kennedy, Rabinovitch, Ladiges: Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. dans The journals of gerontology. Series A, Biological sciences and medical sciences 2009
Human Polyclonal PRKACA Primary Antibody pour ELISA, WB - ABIN562366
Adachi, Kano, Saido, Murata: Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion. dans Genes to cells : devoted to molecular & cellular mechanisms 2009
Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 (Montrer ARPP19 Anticorps) by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A (Montrer PPP2R4 Anticorps) disinhibition.
CTR (Montrer CALCR Anticorps) activates AKAP2 (Montrer AKAP2 Anticorps)-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 (Montrer TJP1 Anticorps) and claudin 3 (Montrer CLDN3 Anticorps).
These results indicate that Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC (Montrer FAM126A Anticorps)) is similar to pure FL-HCC (Montrer FAM126A Anticorps) at the genomic level and the DNAJB1 (Montrer DNAJB1 Anticorps):PRKACA fusion can be used as a diagnostic tool for both pure and mFL-HCC (Montrer FAM126A Anticorps)
PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are affected by a more severe phenotype and are identified at a younger age.
Somatic mutations in PRKACA, coding for the catalytic alpha subunit (Montrer POLG Anticorps) of protein kinase A (PKA), have been recently identified as the most frequent genetic alteration in cortisol-secreting adrenocortical adenomas, which are responsible for adrenal Cushing's syndrome.
HIF1a (Montrer HIF1A Anticorps) transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation
cigarette smoke extracts activate the PKA, CREB (Montrer CREB1 Anticorps), and IL-13Ralpha2 axis in lung endothelial cells.
Data indicate a subpopulation of the CaV1.2 (Montrer CACNA1C Anticorps) channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
we propose that the PKA-Smurf1 (Montrer SMURF1 Anticorps)-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
The mutated PRKACA proteins lost their ability to bind to PRKAR1A (Montrer PRKAR1A Anticorps), and thereby lead to constitutive activation of the PKA pathway. Together with previous reports of PRKAR1A (Montrer PRKAR1A Anticorps) mutations in syndromic cardiac myxoma, our study demonstrates the importance of the PKA pathway in the tumourigenesis of cardiac myxoma.
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.
structural basis of selectivity for protein kinase A in complex with Rho-kinase (Montrer ROCK1 Anticorps) inhibitors by x-ray crystallography
Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.
ceramide as a potent physiological modulator of the Na(+)-ATPase (Montrer DNAH8 Anticorps), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (Montrer PRKCZ Anticorps)
we demonstrate that PKA, PKC (Montrer FYN Anticorps) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (Montrer GSK3a Anticorps) phosphorylation which subsequently controls cell motility.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB (Montrer CREB1 Anticorps) signaling.
Generation of the Dnajb1 (Montrer DNAJB1 Anticorps)-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (Montrer SCP2 Anticorps)), a form of synaptic plasticity that requires Cav1.2 (Montrer CACNA1C Anticorps) and enhancement of its activity by the beta2-adrenergic receptor (Montrer ADRB2 Anticorps) (beta2AR (Montrer ADRB2 Anticorps))-cAMP-PKA cascade.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (Montrer NRG1 Anticorps) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
study identifies a new role of Dual-AKAP1 (Montrer AKAP1 Anticorps) in regulating mitochondrial trafficking through Miro-2 (Montrer RHOT2 Anticorps), and supports a model in which PINK1 (Montrer PINK1 Anticorps) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (Montrer SHH Anticorps) signaling through regulation of GLI3 (Montrer GLI3 Anticorps) processing.
this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (Montrer CSF1R Anticorps) DNA methylation (Montrer HELLS Anticorps) resulting in macrophage maturation
support hypothesis that PRKACA activation is responsible for downstream protein tyrosine phosphorylation events in stallion sperm
Thus Ca(2 (Montrer CA2 Anticorps)+)-cAMP/PKA-dependent phosphorylation limits the rate and magnitude of increase in spontaneous action potential firing rate.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
, cAMP-dependent protein kinase catalytic subunit alpha
, protein kinase A catalytic subunit
, cAMP-dependent protein kinase catalytic subunit C alpha
, protein kinase A
, protein kinase, cAMP-dependent, catalytic, alpha
, C-alpha subunit
, sperm cAMP-dependent protein kinase catalytic subunit
, protein kinase A alpha
, PKA catalytic subunit alpha