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anti-Human PRKACA Anticorps:
anti-Rat (Rattus) PRKACA Anticorps:
anti-Mouse (Murine) PRKACA Anticorps:
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Human Polyclonal PRKACA Primary Antibody pour ELISA, WB - ABIN562366
Adachi, Kano, Saido, Murata: Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion. dans Genes to cells : devoted to molecular & cellular mechanisms 2009
Ezrin (Montrer EZR Anticorps)-anchored PKA phosphorylates serine 369 and 373 on connexin 43 (Montrer GJA1 Anticorps) to enhance gap junction assembly, communication, and cell fusion.
CaV1.4 (Montrer CACNA1F Anticorps) channels are indeed modulated by PKA phosphorylation within the inhibitor of Ca(2 (Montrer CA2 Anticorps)+)-dependent inactivation (ICDI) motif.
In this study, the authors linked for the first time the loss of RIIbeta (Montrer PRKAR2B Anticorps) protein levels to the PRKACA mutation status and found the down-regulation of RIIbeta (Montrer PRKAR2B Anticorps) to arise post-transcriptionally.
the presence of lipofuscin in cortisol-producing adenomas (CPAs) responsible for Cushing syndrome with and without the PRKACA (pLeu206Arg) somatic mutation, was investigated.
Mechanistically, Sirt1 (Montrer SIRT1 Anticorps) expression elevates phosphorylation of the alpha subunit (Montrer POLG Anticorps) of protein kinase A (PKA alpha), and this event is essential for Sirt1 (Montrer SIRT1 Anticorps)-induced phosphorylation of beta Catenin (Montrer CTNNB1 Anticorps).
Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 (Montrer ARPP19 Anticorps) by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A (Montrer PPP2R4 Anticorps) disinhibition.
CTR (Montrer CALCR Anticorps) activates AKAP2 (Montrer AKAP2 Anticorps)-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 (Montrer TJP1 Anticorps) and claudin 3 (Montrer CLDN3 Anticorps).
These results indicate that Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC (Montrer FAM126A Anticorps)) is similar to pure FL-HCC (Montrer FAM126A Anticorps) at the genomic level and the DNAJB1 (Montrer DNAJB1 Anticorps):PRKACA fusion can be used as a diagnostic tool for both pure and mFL-HCC (Montrer FAM126A Anticorps)
PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are affected by a more severe phenotype and are identified at a younger age.
Somatic mutations in PRKACA, coding for the catalytic alpha subunit (Montrer POLG Anticorps) of protein kinase A (PKA), have been recently identified as the most frequent genetic alteration in cortisol-secreting adrenocortical adenomas, which are responsible for adrenal Cushing's syndrome.
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.
structural basis of selectivity for protein kinase A in complex with Rho-kinase (Montrer ROCK1 Anticorps) inhibitors by x-ray crystallography
Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.
ceramide as a potent physiological modulator of the Na(+)-ATPase (Montrer DNAH8 Anticorps), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (Montrer PRKCZ Anticorps)
we demonstrate that PKA, PKC (Montrer FYN Anticorps) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (Montrer GSK3a Anticorps) phosphorylation which subsequently controls cell motility.
The cooperativity mechanism of Pkaca critically depends on the presence of water in two distinct, buried hydration sites.
Study validates the DNAJB1 (Montrer DNAJB1 Anticorps)-PRKACA fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin (Montrer CTNNB1 Anticorps).
Protein kinase A signaling explains vasopressin (Montrer AVP Anticorps)-mediated regulation of membrane trafficking and gene transcription.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB (Montrer CREB1 Anticorps) signaling.
HIF1a (Montrer HIF1A Anticorps) transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation
Generation of the Dnajb1 (Montrer DNAJB1 Anticorps)-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma.
Data indicate a subpopulation of the CaV1.2 (Montrer CACNA1C Anticorps) channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (Montrer SCP2 Anticorps)), a form of synaptic plasticity that requires Cav1.2 (Montrer CACNA1C Anticorps) and enhancement of its activity by the beta2-adrenergic receptor (Montrer ADRB2 Anticorps) (beta2AR (Montrer ADRB2 Anticorps))-cAMP-PKA cascade.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (Montrer NRG1 Anticorps) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
study identifies a new role of Dual-AKAP1 (Montrer AKAP1 Anticorps) in regulating mitochondrial trafficking through Miro-2 (Montrer RHOT2 Anticorps), and supports a model in which PINK1 (Montrer PINK1 Anticorps) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
support hypothesis that PRKACA activation is responsible for downstream protein tyrosine phosphorylation events in stallion sperm
Thus Ca(2 (Montrer CA2 Anticorps)+)-cAMP/PKA-dependent phosphorylation limits the rate and magnitude of increase in spontaneous action potential firing rate.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
, cAMP-dependent protein kinase catalytic subunit alpha
, protein kinase A catalytic subunit
, cAMP-dependent protein kinase catalytic subunit C alpha
, protein kinase A
, protein kinase, cAMP-dependent, catalytic, alpha
, C-alpha subunit
, sperm cAMP-dependent protein kinase catalytic subunit
, protein kinase A alpha
, PKA catalytic subunit alpha