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Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN1344400
Bossen, Cachero, Tardivel, Ingold, Willen, Dobles, Scott, Maquelin, Belnoue, Siegrist, Chevrier, Acha-Orbea, Leung, Mackay, Tschopp, Schneider: TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. dans Blood 2008
Show all 2 Pubmed References
Human TNFSF13B Protein expressed in HEK-293 Cells - ABIN1344293
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. dans PLoS ONE 2012
Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN413043
Kern, Cornuel, Billard, Tang, Rouillard, Stenou, Defrance, Ajchenbaum-Cymbalista, Simonin, Feldblum, Kolb: Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. dans Blood 2004
Equine adipose-derived stem cell (ASC (Montrer PYCARD Protéines)) expresses BAFF (TNFSF13B) and its receptors, which may be associated with the differentiation process of ASC (Montrer PYCARD Protéines) towards adipocyte.
soluble BCMA (Montrer TNFRSF17 Protéines) sequesters circulating BAFF, thereby preventing it from performing its signaling to stimulate normal B-cell and plasma cell development, resulting in reduced polyclonal antibody levels in multiple myeloma patients.
results showed that serum BAFF in nasal type, extranodal NK/T cell lymphoma patients was significantly higher than that in control group and negatively correlated with patients' survival.
BAFF has a role in inducing IL35 (Montrer EBI3 Protéines) production by regulatory B cells in lupus
Inhibition of ADAM10 (Montrer ADAM10 Protéines) augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 (Montrer ADAM17 Protéines) increases BAFFR (Montrer TNFRSF13C Protéines) expression levels
Data presented show that B-cell activating factor (BAFF) plays a central role in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies and suggest a therapeutic potential for BAFF blockade in limiting autoimmune processes associated with smoking.
Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand (Montrer CAMLG Protéines) interactor (TACI (Montrer TNFRSF13B Protéines)) and B cell maturation antigen (BCMA (Montrer TNFRSF17 Protéines)) do not change
The BAFF promoter increased in response to TNF-alpha (Montrer TNF Protéines) treatment or overexpression of HIF-1alpha (Montrer HIF1A Protéines). However, TNF-alpha (Montrer TNF Protéines)-induced BAFF expression and promoter activity decreased after treatment with the ERK (Montrer EPHB2 Protéines) inhibitor PD98059.
This study indicates that orbital fibroblasts from Graves' orbitopathy can express BAFF and mediate the intraorbital survival of B cells via BAFF mechanism.
Inhibition of B cell plasmablast differentiation by reduction of Aiolos (Montrer IKZF3 Protéines) and Ikaros (Montrer IKZF1 Protéines) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos (Montrer IKZF3 Protéines) may prime CD27 (Montrer CD27 Protéines)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.
BCMA (Montrer TNFRSF17 Protéines) has other contributors for ligands binding except DxL motif. The affinity of BCMA (Montrer TNFRSF17 Protéines) for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
This study suggests that BAFF selects IL-10 (Montrer IL10 Protéines)(-)B cells over IL-10 (Montrer IL10 Protéines)(+) regulatory B cells via BAFF receptors in inflammatory responses
BAFF plays a previously unappreciated role in lupus nephritis by inducing renal tertiary lymphoid structures and regulating the position of T cells within the glomeruli.
this study shows that BAFF overexpression reduces hypercholesterolemia and atherosclerosis in hyperlipidemic mice via TACI (Montrer TNFRSF13B Protéines)-dependent B cell activation (Montrer BLNK Protéines)
B cell-activating factor (BAFF) upregulates CD28 (Montrer CD28 Protéines)/B7 and CD40 (Montrer CD40 Protéines)/CD154 (Montrer CD40LG Protéines) expression, and promotes the interactions between T and B cells in a BAFF receptor (Montrer TNFRSF13C Protéines)-dependent manner.
findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI (Montrer TNFRSF13B Protéines)-dependent activation of transitional B cells
neutrophils secreted a B cell-activating factor that highly accelerated plasma cell generation and antigen-specific antibody production.
The enhanced thermogenic program was confirmed by higher protein levels of UCP1 (Montrer UCP1 Protéines) and irisin (Montrer FNDC5 Protéines) in female BAFF-/- than in WT mice.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF (Montrer TNF Protéines)) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Increased B-cell activating factor (BAFF) induced B cell differentiation into germinal center (GC) B (Montrer NPR2 Protéines) cells within the autoimmune target tissue.
study reports the molecular cloning, expression and bioactivity of the porcine homologue of human BAFF
This study demonstrated expression of BAFF on cultured monocyte-derived dendritic cells, which was further enhanced by interferon-alpha (Montrer IFNA Protéines) or interferon-gamma (Montrer IFNG Protéines) treatment.
Although BAFF expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (Montrer GUSB Protéines)-associated lymphoid tissue.
BAFF and its receptors during B-cell activation (Montrer BLNK Protéines) and autoantibody production in rabbits derived from selective breeding to develop a reproducible rabbit model of Systemic Lupus Erythematosus, were investigated.
Cloning and expression analysis of B-cell activating factor (BAFF) provide the basis for investigation of its role in regulating rabbit B-lymphocyte (Montrer AKAP17A Protéines) development and immune responses.
BAFF was detected in developing appendix of young rabbits by immunohistochemical staining suggesting that BAFF plays a role during the period following birth when rabbit B-cell development is occurring.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
tumor necrosis factor ligand superfamily member 13B
, tumor necrosis factor (ligand) superfamily, member 13b
, B-cell activating factor
, B-lymphocyte stimulator
, TNF- and APOL-related leukocyte expressed ligand 1
, ApoL related ligand TALL-1
, B-cell-activating factor
, Delta4 BAFF
, TNF and ApoL-related leukocyte expressed ligand 1
, TNF homolog that activates apoptosis
, delta BAFF
, dendritic cell-derived TNF-like molecule
, tumor necrosis factor (ligand) superfamily, member 20
, tumor necrosis factor-like protein ZTNF4
, b cell-activating factor
, tumor necrosis factor superfamily member 13b