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Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN1344400
Bossen, Cachero, Tardivel, Ingold, Willen, Dobles, Scott, Maquelin, Belnoue, Siegrist, Chevrier, Acha-Orbea, Leung, Mackay, Tschopp, Schneider: TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. dans Blood 2008
Show all 2 Pubmed References
Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN413043
Kern, Cornuel, Billard, Tang, Rouillard, Stenou, Defrance, Ajchenbaum-Cymbalista, Simonin, Feldblum, Kolb: Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. dans Blood 2004
Human TNFSF13B Protein expressed in HEK-293 Cells - ABIN1344293
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. dans PLoS ONE 2012
Equine adipose-derived stem cell (ASC (Montrer PYCARD Protéines)) expresses BAFF (TNFSF13B) and its receptors, which may be associated with the differentiation process of ASC (Montrer PYCARD Protéines) towards adipocyte.
The results suggest that increased levels of BAFF and APRIL produced in the central nervous system may influence the development of anti-neutrophil cytoplasmic antibody-hypertrophic pachymeningitis.
Blood B lymphocyte stimulator (BLyS)/BAFF levels of HIV-uninfected commercial sex workers (CSWs) were lower than those observed in both HIV-infected CSW and HIV-uninfected non-CSW groups.
our study throws light on the crosstalk between BAFF and BCR (Montrer BCR Protéines) signaling pathways in neoplastic B cells, and provides insights into the mechanistic effects of SYK (Montrer SYK Protéines) inhibitors in CLL.
genetic polymorphisms of BAFF may increase the risk of posttransplant development of donor specific antibodies in kidney allograft recipients
P\pre-sensitized patients had significantly higher BAFF levels before transplantation and suffered significantly more often from early steroid-resistant, mainly antibody-mediated rejections
Elevated blood BAFF levels could be associated with a more stable disease.
BAFF rs9514828 polymorphism may be associated with the chronic hepatitis and the combinatorial action of rs9514828 and rs12583006 may confer susceptibility to chronic HBV infection and the resolution of the infection, suggesting that host genetic factors associated with B cell mediated immune responses are involved in chronic HBV infection.
This study demonstrated that An Increase of Cerebrospinal Fluid B-cell Activating Factor Level in Pediatric Patients With Acute Viral Encephalitis.
data show that BAFF levels at the time of cGvHD diagnosis are associated with non-relapse-mortality, and also are potentially useful for risk stratification.
BAFF-R (Montrer TNFRSF13C Protéines) was consistently expressed on B cells infected by HCMV. Enhancement of BAFF/BAFF-R (Montrer TNFRSF13C Protéines) signaling decreased the apoptosis rate and extended the survival of B cells.
results indicate that the BAFF-BAFFR (Montrer TNFRSF13C Protéines) ligation bridged between microglia and neurons could play a critical neuroprotective role in brain ischemic injuries
Data presented show that B-cell activating factor (BAFF) plays a central role in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies and suggest a therapeutic potential for BAFF blockade in limiting autoimmune processes associated with smoking.
This study suggests that BAFF selects IL-10 (Montrer IL10 Protéines)(-)B cells over IL-10 (Montrer IL10 Protéines)(+) regulatory B cells via BAFF receptors in inflammatory responses
BAFF plays a previously unappreciated role in lupus nephritis by inducing renal tertiary lymphoid structures and regulating the position of T cells within the glomeruli.
this study shows that BAFF overexpression reduces hypercholesterolemia and atherosclerosis in hyperlipidemic mice via TACI (Montrer TNFRSF13B Protéines)-dependent B cell activation (Montrer BLNK Protéines)
B cell-activating factor (BAFF) upregulates CD28 (Montrer CD28 Protéines)/B7 and CD40 (Montrer CD40 Protéines)/CD154 (Montrer CD40LG Protéines) expression, and promotes the interactions between T and B cells in a BAFF receptor (Montrer TNFRSF13C Protéines)-dependent manner.
findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI (Montrer TNFRSF13B Protéines)-dependent activation of transitional B cells
neutrophils secreted a B cell-activating factor that highly accelerated plasma cell generation and antigen-specific antibody production.
The enhanced thermogenic program was confirmed by higher protein levels of UCP1 (Montrer UCP1 Protéines) and irisin (Montrer FNDC5 Protéines) in female BAFF-/- than in WT mice.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF (Montrer TNF Protéines)) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
study reports the molecular cloning, expression and bioactivity of the porcine homologue of human BAFF
This study demonstrated expression of BAFF on cultured monocyte-derived dendritic cells, which was further enhanced by interferon-alpha (Montrer IFNA Protéines) or interferon-gamma (Montrer IFNG Protéines) treatment.
Although BAFF expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (Montrer GUSB Protéines)-associated lymphoid tissue.
BAFF and its receptors during B-cell activation (Montrer BLNK Protéines) and autoantibody production in rabbits derived from selective breeding to develop a reproducible rabbit model of Systemic Lupus Erythematosus, were investigated.
Cloning and expression analysis of B-cell activating factor (BAFF) provide the basis for investigation of its role in regulating rabbit B-lymphocyte (Montrer AKAP17A Protéines) development and immune responses.
BAFF was detected in developing appendix of young rabbits by immunohistochemical staining suggesting that BAFF plays a role during the period following birth when rabbit B-cell development is occurring.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
tumor necrosis factor ligand superfamily member 13B
, tumor necrosis factor (ligand) superfamily, member 13b
, B-cell activating factor
, B-lymphocyte stimulator
, TNF- and APOL-related leukocyte expressed ligand 1
, ApoL related ligand TALL-1
, B-cell-activating factor
, Delta4 BAFF
, TNF and ApoL-related leukocyte expressed ligand 1
, TNF homolog that activates apoptosis
, delta BAFF
, dendritic cell-derived TNF-like molecule
, tumor necrosis factor (ligand) superfamily, member 20
, tumor necrosis factor-like protein ZTNF4
, b cell-activating factor
, tumor necrosis factor superfamily member 13b