Profil protéine

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Alternative names and synonyms associated with TRAF6

• TNF receptor associated factor 6 (TRAF6) anticorps
• TNF receptor-associated factor 6 (Traf6) anticorps
• TNF receptor associated factor 6 L homeolog (traf6.L) anticorps
• TNF-receptor-associated factor 6 (Traf6) anticorps
• TNF receptor associated factor 6 (Traf6) anticorps
• Afficher tous les noms de gènes
• TNF receptor associated factor 6 (traf6) anticorps
• TNF receptor-associated factor 6 (LOC551819) anticorps
• TNF receptor-associated factor 6 (traf6) anticorps
• TNF receptor associated factor 6 S homeolog (traf6.S) anticorps

• 2310003F17Rik anticorps
• AI851288 anticorps
• C630032O20Rik anticorps
• CG10961 anticorps
• Dmel\\CG10961 anticorps
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• dtraf2 anticorps
• dTRAF6 anticorps
• fi15f02 anticorps
• GB10539 anticorps
• MGC:3310 anticorps
• rnf85 anticorps
• TRAF anticorps
• Traf2 anticorps
• TRAF6 anticorps
• wu:fi15f02 anticorps
• xtraf6 anticorps
• zgc:63704 anticorps

Protein level used designations for TRAF6

E3 ubiquitin-protein ligase TRAF6 , RING finger protein 85 , TNF receptor-associated factor 6 , interleukin-1 signal transducer , TNF receptor-associated factor 6-B , CG10961-PA , TNF-receptor-associated factor 2 , Traf6-PA , TNF-receptor associated factor 6 , TNF receptor-associated factor 6-like , TNF receptor-associated factor 6-A , TNF receptor-associated factor 6, E3 ubiquitin protein ligase