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Dog (Canine) Polyclonal Deltex Homolog 1 Primary Antibody pour ELISA - ABIN4268617
Gupta-Rossi, Storck, Griebel, Reynaud, Weill, Dahan: Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. dans Molecular immunology 2003
Data indicate that decreased expression of deltex E3 ubiquitin ligase (Montrer MUL1 Anticorps) 1 (DTX1) in head and neck squamous cell carcinoma (HNSCC) tumors maybe associated with NOTCH (Montrer NOTCH1 Anticorps) pathway activation and increased migration potential.
Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination.
this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1 (Montrer STAU1 Anticorps).
characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch (Montrer NOTCH1 Anticorps) pathway and a new Kelch-like protein, KLHL6 (Montrer KLHL7 Anticorps)
It is reported that BBAP (Montrer DTX3L Anticorps) and the human family of DTX proteins (DTX1, DTX2 (Montrer DTX2 Anticorps), and DTX3 (Montrer DTX3 Anticorps)) function as E3 ligases based on their capacity for self-ubiquitination.
exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 (Montrer FOXP3 Anticorps) protein
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
NB-3 (Montrer CNTN6 Anticorps)/Notch1 (Montrer NOTCH1 Anticorps) pathway promotes neural progenitor cell differentiation into
Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1 (Montrer MAP2K1 Anticorps).
Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
Deltex can act as a negative regulator of Notch (Montrer NOTCH1 Anticorps) signals in T cells but that endogenous levels of Deltex1 and Deltex2 (Montrer DTX2 Anticorps) are not important for regulating Notch (Montrer NOTCH1 Anticorps) signals during thymocyte development[Deltex1]
Data show that Deltex1 ablation enabled Id1 (Montrer ID1 Anticorps)-expressing progenitors to differentiate to the DN3 (CD44 (Montrer CD44 Anticorps)(-) CD25 (Montrer IL2RA Anticorps)(+)) stage, which was accompanied by enhanced Notch1 (Montrer NOTCH1 Anticorps) expression in T-cell progenitors.
deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function\; however, it may play a role in basic helix-loop-helix transcription factor activity.
E3 ubiquitin-protein ligase DTX1
, protein deltex-1
, deltex homolog 1 (Drosophila)
, fractionated x-irradiation induced transcript 1
, deltex 1
, deltex 1 S homeolog
, deltex 1, E3 ubiquitin ligase S homeolog