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anti-Rat (Rattus) FBXW7 Anticorps:
anti-Human FBXW7 Anticorps:
anti-Mouse (Murine) FBXW7 Anticorps:
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Human Monoclonal FBXW7 Primary Antibody pour IHC (p), ELISA - ABIN527479
Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. dans Cell reports 2012
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Human Polyclonal FBXW7 Primary Antibody pour ICC, IF - ABIN4892424
Lu, Pfeffer: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. dans The Journal of cell biology 2013
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Human Polyclonal FBXW7 Primary Antibody pour IP - ABIN257813
Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. dans Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Polyclonal FBXW7 Primary Antibody pour IF (p), IHC (p) - ABIN1386103
Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. dans Biochemical and biophysical research communications 2015
Human Polyclonal FBXW7 Primary Antibody pour IF, WB - ABIN527477
Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. dans The EMBO journal 2015
Human Monoclonal FBXW7 Primary Antibody pour IHC, WB - ABIN2720979
Wang, Zhang, Zhou, Sun, Zheng, Lu, Gao, Yang, Zhang, Tao, Dou: Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. dans International journal of oncology 2015
Cow (Bovine) Polyclonal FBXW7 Primary Antibody pour IHC, WB - ABIN2782955
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. dans Nature genetics 2014
Cow (Bovine) Polyclonal FBXW7 Primary Antibody pour IHC, WB - ABIN2780093
Huang, Ma, Li, Yu, Zhang, Wei, Jin, Xu, Gao, Huang: NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. dans Oncotarget 2014
Expression of miR (Montrer MLXIP Anticorps)-223 is negatively correlated with F-box and WD repeat domain-containing 7 (FBXW7) expression in cells and tissues.
FBXW7 conduction of tumour suppression was partly through degrading Snai1 (Montrer SNAI1 Anticorps) directly for ubiquitylating regulation in NSCLC.
Data showed that both chemo and radiation sensitivity increased in TE-8 and KYSE140 cells overexpressing FBXW7 compared with mock cells because of the degradation of the anti-apoptotic protein MCL1 (Montrer MCL1 Anticorps).
Fbw7 mutations shifted cellular metabolism toward oxidative phosphorylation and caused context-specific metabolic vulnerabilities.
TINCR suppressed proliferation and invasion through regulating miR (Montrer MLXIP Anticorps)-544a/FBXW7 axis in lung cancer.
Low FBXW7 expression is associated with non-small cell lung cancer.
we identified F-box and WD repeat domain-containing 7 (FBXW7) protein as a direct functional target of miR (Montrer MLXIP Anticorps)-25 in esophageal squamous cell carcinoma (ESCC). In conclusion, the present study supports the potential of miR (Montrer MLXIP Anticorps)-25 as a prognostic predictor with its high expression in cancer tissues and its association with tumor progression by targeting FBXW7 in ESCC
FBXW7 was significantly downregulated in renal cell carcinoma (Montrer MOK Anticorps) cell lines. Upregulation of FBXW7 in 786-O and ACHN (Montrer LARP6 Anticorps) cell lines significantly inhibited cell migration, invasion and EMT (Montrer ITK Anticorps).
FBXW7 missense mutation is associated with metastatic colorectal adenocarcinoma.
miR (Montrer MLXIP Anticorps)-92b-3p inhibition prevented colorectal cancer proliferation, invasion, and migration by upregulating FBXW7, which might suggest the potential role of miR (Montrer MLXIP Anticorps)-92b-3p in colorectal carcinogenesis and metastasis.
FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A (Montrer AHSG Anticorps) to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
the regulatory crosstalk between KLF5 (Montrer KLF5 Anticorps), miR (Montrer MLXIP Anticorps)-29a, and Fbw7/CDC4 cooperatively promotes atherosclerotic development
found that Fbw7 loss caused activation of NF-kappaB (Montrer NFKB1 Anticorps) signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB (Montrer NFKB1 Anticorps) pathway.
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (Montrer HLCS Anticorps)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (Montrer NOTCH2 Anticorps) pathway as observed in patients with HCS (Montrer HLCS Anticorps).
The findings reveal a PLK1-Fbw7-Myc (Montrer MYC Anticorps) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (Montrer BCL2 Anticorps) antagonists, as potential effective therapeutics for MYC (Montrer MYC Anticorps)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (Montrer YAP1 Anticorps)-dependent mechanism.
Study identifies a REV-ERBalpha (Montrer NR1D1 Anticorps) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (Montrer CDK1 Anticorps)) phosphorylation of REV-ERBalpha (Montrer NR1D1 Anticorps) is recognized by the F-box protein (Montrer FBXO30 Anticorps), FBXW7alpha, to direct REV-ERBalpha (Montrer NR1D1 Anticorps) degradation via the proteasome. Disruption of this CDK1 (Montrer CDK1 Anticorps)-FBXW7-mediated REV-ERBalpha (Montrer NR1D1 Anticorps) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (Montrer FRAP1 Anticorps) pathway in radiation-induced mouse thymic lymphomas.
Prion (Montrer PRNP Anticorps) infection induced the expression of FBXW7 in brain.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30