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Genetic interaction between lunatic fringe and TP53 (Montrer TP53 Anticorps) was identified in breast cancer tumorigenesis.
a potent tumor-suppressive function for Lfng
TGFBR2 (Montrer TGFBR2 Anticorps) signaling can affect Notch1 (Montrer NOTCH1 Anticorps) glycosylation via regulation of glycosyltransferase (Montrer GTDC2 Anticorps) LFNG expression and provide a first mechanistic example for altered glycosylation in microsatellite instability colorectal tumor cells.
LFNG expression correlates with expansion of cancer stem cell populations and NKX3.1 (Montrer NKX3-1 Anticorps) expression in human prostate cancer.
Reduced LFNG expression facilitates JAG/NOTCH (Montrer NOTCH1 Anticorps) luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote basal-like breast cancer.
Mutation of the LFNG gene causes spondylocostal dysostosis with a severe vertebral phenotype, reinforcing the hypothesis that proper regulation of the Notch (Montrer NOTCH1 Anticorps) signaling pathway is an absolute requirement for the correct patterning of the axial skeleton.
results suggest that mir (Montrer MLXIP Anticorps)-125a sites in the Lfng 3' untranslated region influence transcript turnover in both mouse and chicken embryos, and support the existence of position-dependent regulatory mechanisms in the presomitic mesoderm.
Lfng-mediated Notch (Montrer NOTCH1 Anticorps) signaling appears to be a key factor governing NSC quiescence, division, and fate.
These results show that Notch (Montrer NOTCH1 Anticorps) signaling is finely calibrated in the cochlea via Lfng and Mfng (Montrer MFNG Anticorps) to produce precisely tuned levels of signaling that first set the boundary of the organ of Corti and later regulate hair cell development.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
LFNG protein may have context-dependent effects on Notch (Montrer NOTCH1 Anticorps) activity; somitogenesis is disrupted by a novel dominant allele of Lfng
Lfng expression and activity is normal in mice whose Lfng is lengthened by 10 kb, and no effects on segmentation are evident.
suggest that modulation of the Notch (Montrer NOTCH1 Anticorps) signaling by Lfng affects the clock period during development
STAT5 (Montrer STAT5A Anticorps)-dependent amplification of Notch (Montrer NOTCH1 Anticorps)-modifying Lfng augments Th2 response via Dll4 (Montrer DLL4 Anticorps) and is critical for amplifying viral exacerbation during allergic airway disease.
The repressive effect of Lfng against Notch (Montrer NOTCH1 Anticorps) activities in neighbouring cells can sufficiently explain the synchronization in vivo.
lfng regulates delta-notch (Montrer NOTCH1 Anticorps) induction of hypochord.
The sequence and embryonic expression of lfng were studied.
Lfng acts in a feedback loop downstream of proneural genes.
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.
, beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
, lunatic fringe gene homolog
, lunatic fringe homolog