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anti-Human NOTCH3 Anticorps:
anti-Mouse (Murine) NOTCH3 Anticorps:
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Human Monoclonal NOTCH3 Primary Antibody pour ELISA, WB - ABIN562028
Park, Shih, Wang: Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. dans Cancer research 2008
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Mouse (Murine) Polyclonal NOTCH3 Primary Antibody pour BR, CyTOF - ABIN5012974
Blanpain, Lowry, Pasolli, Fuchs: Canonical notch signaling functions as a commitment switch in the epidermal lineage. dans Genes & development 2006
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Mouse (Murine) Monoclonal NOTCH3 Primary Antibody pour FACS - ABIN2475922
Droese, Pape, Stolley: [Lipic content and fatty acid pattern in human milk and cow's milk (author's transl)]. dans European journal of pediatrics 1976
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Human Polyclonal NOTCH3 Primary Antibody pour IHC (p), ELISA - ABIN542946
Ahearn, Speer, Chen, Steffens, Cassidy, Van Meter, Provenzale, Weisler, Krishnan: Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. dans American journal of medical genetics 2002
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Human Polyclonal NOTCH3 Primary Antibody pour IHC - ABIN966682
Joutel, Corpechot, Ducros, Vahedi, Chabriat, Mouton, Alamowitch, Domenga, Cécillion, Marechal, Maciazek, Vayssiere, Cruaud, Cabanis, Ruchoux, Weissenbach, Bach, Bousser, Tournier-Lasserve: Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. dans Nature 1996
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Human Polyclonal NOTCH3 Primary Antibody pour IHC - ABIN966685
Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: Human ligands of the Notch receptor. dans The American journal of pathology 1999
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Human Monoclonal NOTCH3 Primary Antibody pour CyTOF, FACS - ABIN4900322
Soriani, Iannitto, Ricci, Fionda, Malgarini, Morrone, Peruzzi, Ricciardi, Petrucci, Cippitelli, Santoni: Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. dans Journal of immunology (Baltimore, Md. : 1950) 2014
Human Polyclonal NOTCH3 Primary Antibody pour IHC (p), IP - ABIN250809
Dang, Fan, Chaudhry, Wang, Gaiano, Eberhart: Notch3 signaling initiates choroid plexus tumor formation. dans Oncogene 2006
Mouse (Murine) Polyclonal NOTCH3 Primary Antibody pour IF, IHC (p) - ABIN390159
Liu, Yang, Wang, Miao, Liu, Li, Zou, Li, Liang, Zeng, Chen: The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance. dans Pathology oncology research : POR 2017
aberrantly expressed in the pathological tumour vascularization where it limits tumour angiogenesis through a pro-apoptotic activity
TGFbeta activates the transcription factor ZEB1 to repress Notch3, thereby limiting terminal differentiation.
A novel NOTCH3 pathogenic variant (p.N1969 *) in the intracellular ankyrin repeat domain is detected in three CADASIL patients.
TNFalpha regulates NOTCH2 and NOTCH3 expression in pulmonary artery smooth muscle cells via preferential ACTR-IIA signalling in BMPR-II-deficient cells.
SIRT6 may suppress cell proliferation, migration, and invasion via inhibition of the NOTCH3 signaling pathway in glioma
hus Notch3 appears to be a promising target for gene therapy and DAPT is able to mediate a strong antitumor effect in nonsmall cell lung cancer (NSCLC) cells that overexpress Notch3. Further studies of a combined treatment regimen with DAPT and GEM are warranted and may provide greater efficacy and safety in the treatment of NSCLC patients
Adult-onset Mendelian leukodystrophy genes are not common factors implicated in Alzheimer's disease, but there is a potential pathogenic link between NOTCH3, CSF1R, and sporadic late-onset Alzheimer's disease.
Vascular smooth muscle cells were cyclically stretched on flexible membranes. Expression of Jagged1, Notch3, and target genes was down-regulated with strain. Upon increasing thickness, the model predicted a switch-type behavior of Notch signaling state with a steep transition of synthetic toward contractile VSMCs at a certain thickness. The Notch response to hemodynamics plays an important role in vascular homeostasis.
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes Notch3-driven leukemia development.
We describe a CADASIL family with a novel R110C mutation in the NOTCH3 gene
The levels of markers related to PaSC activation, such as a-smooth muscle actin (alpha-SMA), collagen I and fibronectin, decreased in response to Notch3 knockdown, indicating that Notch3 plays an important role in PaSC activation. Furthermore, we confirmed that inhibition of PaSC activation via Notch3 siRNA reduced the proliferation and migration of PaSC-induced mouse pancreatic cancer (LTPA) cells.
The novel variant c.128G>C in exon 2 of NOTCH3 was identified in 2 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 activation, resulting in attenuation of Notch3-mediated signaling pathways.
These findings broaden the mutational and clinical spectrum of CADASIL and provide additional evidences for the existence of founder effect in CADASIL patients.
Our study also suggested the anti-neoplasm effect of mangiferin might be via the regulation of Notch3. Taken together, by targeting cell apoptosis pathways and enhancing the response to cisplatin treatment, mangiferin may represent a potential new drug for the treatment of human ovarian cancer.
Results found that Notch3 was more highly expressed in human urothelial cancer tissues than in non-tumorous bladder tissue samples, with Notch3 overexpression being associated with poor clinical outcome. These data suggested that Notch 3 overexpression promotes growth and chemoresistance in urothelial cancer.
Two heterozygous missense mutations in the NOTCH3 gene have been identified in two families affected with cerebral autosomal dominant arteriopathy with subcortical infarct and leucoencephalopathy
The results reveal a new connection between p38MAPK, MYC and NOTCH signaling, demonstrate two mechanisms of NOTCH3 regulation and provide evidence for NOTCH3 involvement in prostate luminal cell differentiation.
Results identified NOTCH3 as a direct target of MIR-613 which represses notch3 expression via targeting its 3'TUR. IN contrary, HOTAIR positively regulates the notch3 expression via acting as a competing endogenous RNA for miR-613 binding in pancreatic cancer.
The present study identified a novel variant (chr19:15288426A>C) in the NOTCH3 gene using whole exome sequencing and confirmed it using Sanger sequencing. With multiple in silico analyses and 3D structure simulation, it is suggested that this variant has mildly damaging effects on the function of NOTCH3 gene, but can decrease protein stability.
The results demonstrate that quiescence and stemness are molecularly distinct outputs of Notch3 signalling, and identify Hey1 as a major Notch3 effector controlling NSC stemness in the vertebrate adult brain.
The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC) emergence in a non-cell-autonomous manner.
90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b.
Notch3 regulates oligodendrocyte precursor cells development and mbp gene expression in larvae, and maintains vascular integrity in adults.
new role for Notch signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population
Notch3 activity gates neural stem cell activation in the adult pallium.
Cellular correlates of Notch-delta gene expression in the regenerating zebrafish retina.
knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Notch homolog 3
, neurogenic locus notch homolog protein 3
, Notch gene homolog 3