Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Human NOTCH3 Anticorps:
anti-Mouse (Murine) NOTCH3 Anticorps:
anti-Rat (Rattus) NOTCH3 Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Human Monoclonal NOTCH3 Primary Antibody pour ELISA, WB - ABIN562028
Park, Shih, Wang: Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. dans Cancer research 2008
Show all 7 Pubmed References
Human Polyclonal NOTCH3 Primary Antibody pour IHC - ABIN966682
Joutel, Corpechot, Ducros, Vahedi, Chabriat, Mouton, Alamowitch, Domenga, Cécillion, Marechal, Maciazek, Vayssiere, Cruaud, Cabanis, Ruchoux, Weissenbach, Bach, Bousser, Tournier-Lasserve: Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. dans Nature 1996
Show all 3 Pubmed References
Human Polyclonal NOTCH3 Primary Antibody pour IHC - ABIN966685
Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: Human ligands of the Notch receptor. dans The American journal of pathology 1999
Show all 3 Pubmed References
Mouse (Murine) Monoclonal NOTCH3 Primary Antibody pour FACS - ABIN2475922
Droese, Pape, Stolley: [Lipic content and fatty acid pattern in human milk and cow's milk (author's transl)]. dans European journal of pediatrics 1976
Show all 4 Pubmed References
Mouse (Murine) Polyclonal NOTCH3 Primary Antibody pour BR, CyTOF - ABIN5012974
Blanpain, Lowry, Pasolli, Fuchs: Canonical notch signaling functions as a commitment switch in the epidermal lineage. dans Genes & development 2006
Show all 3 Pubmed References
Human Polyclonal NOTCH3 Primary Antibody pour IHC (p), IP - ABIN250809
Dang, Fan, Chaudhry, Wang, Gaiano, Eberhart: Notch3 signaling initiates choroid plexus tumor formation. dans Oncogene 2006
Human Polyclonal NOTCH3 Primary Antibody pour IHC (fro), IHC - ABIN408754
Soylu, Acar, Ozbey, Unal, Koksal, Bassorgun, Ciftcioglu, Ustunel: Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma. dans Pathology oncology research : POR 2015
Mouse (Murine) Polyclonal NOTCH3 Primary Antibody pour IF, IHC (p) - ABIN390159
Liu, Yang, Wang, Miao, Liu, Li, Zou, Li, Liang, Zeng, Chen: The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance. dans Pathology oncology research : POR 2017
Human Monoclonal NOTCH3 Primary Antibody pour CyTOF, FACS - ABIN4900322
Soriani, Iannitto, Ricci, Fionda, Malgarini, Morrone, Peruzzi, Ricciardi, Petrucci, Cippitelli, Santoni: Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. dans Journal of immunology (Baltimore, Md. : 1950) 2014
hus (Montrer CFH Anticorps) Notch3 appears to be a promising target for gene therapy and DAPT is able to mediate a strong antitumor effect in nonsmall cell lung cancer (NSCLC) cells that overexpress Notch3. Further studies of a combined treatment regimen with DAPT and GEM (Montrer GEM Anticorps) are warranted and may provide greater efficacy and safety in the treatment of NSCLC patients
Adult-onset Mendelian leukodystrophy genes are not common factors implicated in Alzheimer's disease, but there is a potential pathogenic link between NOTCH3, CSF1R (Montrer CSF1R Anticorps), and sporadic late-onset Alzheimer's disease.
Vascular smooth muscle cells were cyclically stretched on flexible membranes. Expression of Jagged1 (Montrer JAG1 Anticorps), Notch3, and target genes was down-regulated with strain. Upon increasing thickness, the model predicted a switch-type behavior of Notch (Montrer NOTCH1 Anticorps) signaling state with a steep transition of synthetic toward contractile VSMCs at a certain thickness. The Notch (Montrer NOTCH1 Anticorps) response to hemodynamics plays an important role in vascular homeostasis.
A threshold level of NFATc1 (Montrer NFATC1 Anticorps) activity facilitates thymocyte differentiation and opposes Notch3-driven leukemia development.
We describe a CADASIL family with a novel R110C mutation in the NOTCH3 gene
The levels of markers related to PaSC activation, such as a-smooth muscle actin (alpha-SMA (Montrer SMN1 Anticorps)), collagen I and fibronectin (Montrer FN1 Anticorps), decreased in response to Notch3 knockdown, indicating that Notch3 plays an important role in PaSC activation. Furthermore, we confirmed that inhibition of PaSC activation via Notch3 siRNA reduced the proliferation and migration of PaSC-induced mouse pancreatic cancer (LTPA) cells.
The novel variant c.128G>C in exon 2 of NOTCH3 was identified in 2 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 (Montrer CHAC1 Anticorps) and reduced Notch3 levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 (Montrer CHAC1 Anticorps) pathway inhibits Notch3 activation, resulting in attenuation of Notch3-mediated signaling pathways.
These findings broaden the mutational and clinical spectrum of CADASIL and provide additional evidences for the existence of founder effect in CADASIL patients.
Our study also suggested the anti-neoplasm effect of mangiferin might be via the regulation of Notch3. Taken together, by targeting cell apoptosis pathways and enhancing the response to cisplatin treatment, mangiferin may represent a potential new drug for the treatment of human ovarian cancer.
Double immunostaining with differentiation markers revealed that NOTCH3 was expressed in some undifferentiated and differentiated spermatogonia in mouse testes.
We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k-Akt (Montrer AKT1 Anticorps)
Notch3 mutation impairs recovery of cardiac function post-myocardial ischemia.
Notch3 plays an important role in the maintenance of quiescent neural stem cells in the subependymal zone.
Lnc-LFAR1 binds directly to Smad2 (Montrer SMAD2 Anticorps)/3 and promotes transcription of TGFbeta (Montrer TGFB1 Anticorps), Smad2 (Montrer SMAD2 Anticorps), Smad3 (Montrer SMAD3 Anticorps), Notch2 (Montrer NOTCH2 Anticorps) and Notch3 which, in turn, results in TGFbeta (Montrer TGFB1 Anticorps) and Notch (Montrer NOTCH1 Anticorps) pathway activation.
this study shows that Notch (Montrer NOTCH1 Anticorps) signaling regulates basophils biological function, at least partially via the modulation of MAPK (Montrer MAPK1 Anticorps)
Knock-in mice with the R169C mutation (Notch3(R170C/R170C)) exhibited similar reductions in arterial lumen, and both TgNotch3(R169C) and Notch3(R170C/R170C) mice showed increased cerebral artery expression of Notch3 target genes.
Notch3 is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 is attributable to its action on TGF-beta1 (Montrer TGFB1 Anticorps)/Smad3 (Montrer SMAD3 Anticorps) signaling.
Data indicate that Notch (Montrer NOTCH1 Anticorps) receptors Notch1 (Montrer NOTCH1 Anticorps) and Notch3 deficiency compromises pericyte function and contributes to vascular pathologies.
In this study, authors use a smooth muscle-specific (Montrer EIF3K Anticorps) deletion of Notch2 (Montrer NOTCH2 Anticorps) together with a global Notch3 deletion to produce mice with combinations of mutant and wild-type Notch2 (Montrer NOTCH2 Anticorps)/3 alleles in vascular smooth muscle cells
The results demonstrate that quiescence and stemness are molecularly distinct outputs of Notch3 signalling, and identify Hey1 (Montrer HEY1 Anticorps) as a major Notch3 effector controlling NSC stemness in the vertebrate adult brain.
The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC (Montrer FUT1 Anticorps)) emergence in a non-cell-autonomous manner.
90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b.
Notch3 regulates oligodendrocyte precursor cells development and mbp (Montrer MBP Anticorps) gene expression in larvae, and maintains vascular integrity in adults.
new role for Notch (Montrer NOTCH1 Anticorps) signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population
Notch3 activity gates neural stem cell activation in the adult pallium.
Cellular correlates of Notch (Montrer NOTCH1 Anticorps)-delta gene expression in the regenerating zebrafish retina.
knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Notch homolog 3
, neurogenic locus notch homolog protein 3
, Notch gene homolog 3