Aperçu des produits pour anti-CHEK1 (CHEK1) Anticorps

Full name:: anti-Checkpoint Kinase 1 Anticorps (CHEK1)

Chez www.anticorps-enligne.fr sont 524 Checkpoint Kinase 1 (CHEK1) Anticorps de 33 de différents fournisseurs disponibles. De plus, nous expédions CHEK1 Kits (22) et CHEK1 Protéines (22) et beaucoup plus de produits pour cette protéine. Un total de 610 CHEK1 produits sont actuellement listés.

Synonymes:: An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093

afficher tous les anticorps	Gène	GeneID	UniProt
	CHEK1	1111	O14757
	CHEK1	12649	O35280
	CHEK1	140583	Q91ZN7
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Human Polyclonal CHEK1 Primary Antibody pour ICC, IF - ABIN151911 : Karnani, Dutta: The effect of the intra-S-phase checkpoint on origins of replication in human cells. dans Genes & development 2011 (PubMed)
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Human Polyclonal CHEK1 Primary Antibody pour IHC - ABIN965885 : Zhang, Otterness, Chiang, Xie, Liu, Mercurio, Abraham: Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. dans Molecular cell 2005 (PubMed)
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Human Polyclonal CHEK1 Primary Antibody pour IP, PLA - ABIN151777 : Sun, Shieh: Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. dans Oncogene 2009 (PubMed)
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Human Polyclonal CHEK1 Primary Antibody pour IHC, IHC (p) - ABIN4297951 : Zhou, Chen, Malysa, Li, Oliveira, Zhang, Bepler: A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy. dans PLoS ONE 2013 (PubMed)
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Human Polyclonal CHEK1 Primary Antibody pour IHC - ABIN965886 : Clarke, Colantonio, Heslegrave, Rhodes, Links, Conn: Holocaust experience and suicidal ideation in high-risk older adults. dans The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004 (PubMed)
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Human Polyclonal CHEK1 Primary Antibody pour ELISA, WB - ABIN965881 : Sanchez, Wong, Thoma, Richman, Wu, Piwnica-Worms, Elledge: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. dans Science (New York, N.Y.) 1997 (PubMed)
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Human Polyclonal CHEK1 Primary Antibody pour ICC, IF - ABIN439073 : Tarjan, Haines, Vesper, Xue, Altman, Yarmolyuk, Khurram, Elseth, Roeske, Aydogan, Radosevich: Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines. dans Tumour biology 2010 (PubMed)
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Human Monoclonal CHEK1 Primary Antibody pour WB - ABIN387806 : Greenow, Clarke, Jones: Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. dans Oncogene 2009 (PubMed)
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Human Monoclonal CHEK1 Primary Antibody pour WB - ABIN446614 : Chang, Chan, R McGhie, Udugama, Mayne, Collas, Mann, Wong: CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. dans Nucleic acids research 2015 (PubMed)
Human Monoclonal CHEK1 Primary Antibody pour ELISA, WB - ABIN965882 : OConnell, Raleigh, Verkade, Nurse: Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. dans The EMBO journal 1997 (PubMed)
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Plus d’anticorps contre CHEK1 partenaires d’interaction

Human Checkpoint Kinase 1 (CHEK1) interaction partners

expression of AURKA (Montrer AURKA Anticorps) and CHEK1 was linked with detrimental outcome in patients. Our data describe a synthetic lethality interaction between CHEK1 and AURKA (Montrer AURKA Anticorps) inhibitors with potential translation to the clinical setting
DNA alkylation damage leads to ATR (Montrer ANTXR1 Anticorps)-Chk1 activation in cancer cells and ATR (Montrer ANTXR1 Anticorps)-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage.
Expression levels of phosphorylated cdc25A (p-cdc25A) and phosphorylated Chk1 (p-Chk1), belonging to the ATR pathway, were decreased by treatment with Dclk1 inhibitor LRRK2-IN-1 (LRRK), indicating Dclk1 involvement in the ATR pathway
these data demonstrate that prexasertib is a specific inhibitor of CHK1 in neuroblastoma (Montrer ARHGEF16 Anticorps) and leads to DNA damage and cell death in preclinical models of this devastating pediatric malignancy.
our results identify a novel link between XRRA1 (Montrer XRRA1 Anticorps) and the ATM (Montrer ATM Anticorps)/CHK1/2 pathway and suggest that XRRA1 (Montrer XRRA1 Anticorps) is involved in a DNA damage response that drives radio- and chemoresistance by regulating the ATM (Montrer ATM Anticorps)/CHK1/2 pathway.
results show that HGF (Montrer HGF Anticorps) was involved in regulating Chk1 phosphorylation, and further demonstrate that AKT (Montrer AKT1 Anticorps) activity was responsible for this HGF (Montrer HGF Anticorps)-induced Chk1 phosphorylation.
Chk1 was linked to DNA damage response bypass by suppressing JNK (Montrer MAPK8 Anticorps) activation following oxidative stress, promoting cell cycle progression despite DNA damage.
inhibition of Chk1 can potentiate activity of nucleoside analogs in TP53 (Montrer TP53 Anticorps)-mutated B-lymphoid cells
Data show that protein phosphatase-1 (Montrer PPP1CB Anticorps) alpha (PP1alpha (Montrer PPP1CA Anticorps)) is required to maintain checkpoint kinase 1 (CHK1) in a dephosphorylated state and for the accelerated replication fork progression in Spi1 (Montrer SPI1 Anticorps)/PU.1 transcription factor-overexpressing cells.
Following DNA damage, addition of the TLK1 (Montrer TLK1 Anticorps) inhibitor, THD, or overexpression of NEK1 (Montrer NEK1 Anticorps)-T141A mutant impaired ATR (Montrer ANTXR1 Anticorps) and Chk1 activation, indicating the existence of a TLK1 (Montrer TLK1 Anticorps)>NEK1 (Montrer NEK1 Anticorps)>ATR (Montrer ANTXR1 Anticorps)>Chk1 pathway. Indeed, overexpression of the NEK1 (Montrer NEK1 Anticorps)-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

Inhibition of Drf1 (Montrer DBF4B Anticorps) is the primary mechanism by which Chk1 blocks cell-cycle progression in the early embryo and is an essential function of Chk1 at the blastula-to-gastrula stage of development.
The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.
ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.
Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (Montrer CDC45 Anticorps) onto chromatin and thereby serves to antagonize the initiation of replication.
The MRN complex, in particular the nuclease (Montrer DCLRE1C Anticorps) activity of Mre11 (Montrer MRE11A Anticorps), plays an important role in the activation of Chk1 in response to stalled replication forks.
DNA polymerase kappa (Montrer POLK Anticorps)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.
APE2 (Montrer APEX2 Anticorps) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (Montrer APEX2 Anticorps) is essential for Chk1 phosphorylation, indicating a Claspin (Montrer CLSPN Anticorps)-like but distinct role for APE2 (Montrer APEX2 Anticorps) in ATR (Montrer ATR Anticorps)-Chk1 signaling.
Data show that the death pathway is independent of ERK (Montrer MAPK1 Anticorps) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (Montrer CDK1 Anticorps) and JNK (Montrer MAPK8 Anticorps).
Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (Montrer TRH Anticorps)(16) by Chk1.
mechanism of Chk1 activation at the DNA replication checkpoint

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

During neurogenesis, cortical neurons became protected from S-phase Chk1 pathway activation by the DNA methyltransferase (Montrer DNMT1 Anticorps) Dnmt1 (Montrer DNMT1 Anticorps), and underwent cell death after S-phase progression.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (Montrer TRAF1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps)-regulated apoptosis and the p53 (Montrer TP53 Anticorps)/PCNA (Montrer PCNA Anticorps)- and ATM (Montrer ATM Anticorps)/ATR (Montrer ATR Anticorps)-Chk1/2-controlled DNA-damage response pathways.
Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan (Montrer SUPT6H Anticorps)-nuclear immunostaining pattern of Histone H2AX.
RAD9 (Montrer RAD9A Anticorps) has a prominent role in the ATR (Montrer ATR Anticorps)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
Acute inactivation of E4F1 (Montrer E4F1 Anticorps) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (Montrer ROS1 Anticorps) production, energy stress, and inhibition of de novo pyrimidine synthesis
Altogether, our results classify E4F1 (Montrer E4F1 Anticorps) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.
Heterozygous loss of Chk1 in a Wnt (Montrer WNT2 Anticorps)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.
PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity
ATM (Montrer ATM Anticorps) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.
High level of phospho-Chk1 is associated with skin tumors.

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

The Chk1 directly phosphorylates eNOS (Montrer NOS3 Anticorps) Ser (Montrer SIGLEC1 Anticorps)(1179) in response to UV irradiation, which is dependent on Hsp90 (Montrer HSP90 Anticorps) interaction.

CHEK1 profil antigène

Antigen Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

checkpoint kinase 1 (CHEK1) anticorps
serine/threonine-protein kinase chk1 (ANI_1_2436074) anticorps
serine/threonine-protein kinase chk1 (AOR_1_768154) anticorps
serine/threonine-protein kinase Chk1 (PTRG_04183) anticorps
CAMK/CAMKL/CHK1 protein kinase Chk1 (SJAG_01680) anticorps
serine/threonine-protein kinase chk1 (PAAG_04978) anticorps
serine/threonine-protein kinase chk1 (MCYG_03290) anticorps
serine/threonine-protein kinase chk1 (VDBG_03742) anticorps
checkpoint kinase 1 S homeolog (chek1.S) anticorps
checkpoint kinase 1 (Chek1) anticorps
checkpoint kinase 1 (chek1) anticorps

An08g10320 anticorps
AO090003000441 anticorps
C85740 anticorps
CHEK1 anticorps
Chk1 anticorps
id:ibd2720 anticorps
rad27 anticorps
zgc:56093 anticorps

Protein level used designations for CHEK1

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

GENE ID	SPECIES
100064353	Equus caballus
4983346	Aspergillus niger CBS 513.88
5991605	Aspergillus oryzae RIB40
6342420	Pyrenophora tritici-repentis Pt-1C-BFP
7049849	Schizosaccharomyces japonicus yFS275
9096078	Paracoccidioides sp. 'lutzii' Pb01
9230546	Arthroderma otae CBS 113480
9532482	Verticillium alfalfae VaMs.102
1111	Homo sapiens
398191	Xenopus laevis
609767	Canis lupus familiaris
12649	Mus musculus
140583	Rattus norvegicus
100511709	Sus scrofa
393162	Danio rerio
513678	Bos taurus
374260	Gallus gallus

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