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Increased levels of FASL in patients with CHD.
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The pY291-Fas is essential for the EGF-induced formation of the Fas-mediated nuclear EGFR/STAT3 signaling complex.
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Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling.
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Direct cell contacts between platelets and RBCs via FasL/FasR were shown in surgical specimens of patients after thrombectomy.
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Data show that the diagnostic ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to identify an elevated HbF was significantly higher than that of the CD95 (Fas).
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Fas promotes TH9 cell differentiation by activating NF-kappaB via Ca(2+)-dependent PKC-beta activation.
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Hsa-let-7b-5p helps intracellular survival of MTB in THP-1 cells by downregulating Fas protein level.
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The levels of expression of Bcl-2, CD95, and active caspase-3 in blasts of patients with Acute lymphoblastic leukemia, indicate that apoptosis is inhibited both in intrinsic and extrinsic pathways, mainly in patients with B-Acute lymphoblastic leukemia, B-Acute lymphoblastic leukemia/CD33+ and ambiguous lineage-lymphoblastic leukemia.
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The data identify FADD as a novel component of the noncanonical TLR4/IFN-beta signaling pathway and demonstrate that both Fas and its adaptor FADD can differentially regulate the production of LPS-induced proinflammatory cytokines and type I interferons.
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Results found that Fas mRNA expression in the exposed group were significantly higher than that in the control group. The levels of gene expression were positively correlated with the concentrations of urinaryinorganic arsenic, monomethylarsonic acid and dimethylarsinic acid in all subjects.
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The current research reveals a vital role of CRIP1 in colorectal cancer(CRC) progression, which provide a novel target for clinical drug resistance of colorectal cancer and undoubtedly contributing to the therapeutic strategies in CRC.
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The initial activation of CD95 occurs locally and is limited to the contact region of the cytotoxic synapse.
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Hybridization-based panel sequencing of patients with well-characterized primary cutaneous marginal zone lymphoma identified genetic alterations in the FAS gene which affect the functionally relevant death domain of the apoptosis-regulating FAS/CD95 protein in a dominant-negative manner.
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increased SRSF4 expression stimulates Fas exon 6 inclusion, and that reduced SRSF4 expression promotes exon 6 exclusion.
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CD39, CD43, CD81, and CD95 expressions appear to be helpful to distinguish CD10(+) BCL.
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No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs13416436 and rs2037815 (CASP8 gene). On the other hand, a significant difference between rs3740286 and rs4064 (FAS gene) was found. Regarding polymorphisms in the FAS gene, a statistically significant difference was found in co-dominant and dominant models.
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Fas polymorphism rs1800682 is associated with intervertebral disc degeneration (IVDD), and along with rs2234767, is associated with musculoskeletal degenerative diseases in Chinese population. Fas (rs2234767) correlates with risk of osteoarthritis and rheumatoid arthritis.
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These data indicate that the Fas/FasL system increases pulmonary protein permeability by a direct effect on the alveolar epithelium that involves the alteration of its TJ proteins and permeability properties.
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predisposition to multiple sclerosis as well as to high progression rate are associated with the FAS/APO-1*G/capital A, Cyrillic gene in Russians living in the Altai Territory.
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The proportion of CD8(+)T lymphocytes in peripheral blood of patients with HCC [hepatocellular carcinoma ] is higher than that of healthy controls, but the proportion of CD8(+)T lymphocyte apoptosis based on Fas/FasL pathway increased, which may be an important mechanism for tumor cell immune escape.