Profil protéine

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Alternative names and synonyms associated with FAS

• Fas cell surface death receptor (FAS) anticorps
• Fas ligand (FASLG) anticorps
• Fas ligand (TNF superfamily, member 6) (Fasl) anticorps
• tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ) anticorps
• Fas (TNF receptor superfamily member 6) (Fas) anticorps
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• Fas cell surface death receptor (Fas) anticorps
• Fas cell surface death receptor (fas) anticorps

• AI196731 anticorps
• ALPS1A anticorps
• APO-1 anticorps
• APO1 anticorps
• APT1 anticorps
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• APT1LG1 anticorps
• CD95 anticorps
• CD95-L anticorps
• CD95L anticorps
• CD178 anticorps
• Fas-L anticorps
• FAS1 anticorps
• FASL anticorps
• Faslg anticorps
• FASTM anticorps
• gld anticorps
• lpr anticorps
• TNFR6 anticorps
• Tnfrsf6 anticorps
• Tnfsf6 anticorps

Protein level used designations for FAS

APO-1 cell surface antigen , CD95 antigen , Delta Fas/APO-1/CD95 , FAS 827dupA , FASLG receptor , Fas (TNF receptor superfamily, member 6) , Fas AMA , TNF receptor superfamily member 6 , apoptosis antigen 1 , apoptosis-mediating surface antigen FAS , tumor necrosis factor receptor superfamily member 6 , tumor necrosis factor receptor superfamily, member 6 , fas antigen ligand , tumor necrosis factor (ligand) superfamily, member 6 , tumor necrosis factor ligand superfamily member 6 , Fas antigen , CD95 ligand , Fas antigen ligand , generalized lymphoproliferative disease , 14-3-3 protein zeta/delta , FAS , KCIP-1 , factor activating exoenzyme S , protein kinase C inhibitor protein 1 , Fas (TNF receptor superfamily member) , apo-1 antigen , lymphoproliferation , Fas antigen (ATP1) , Fas receptor , Tumor necrosis factor receptor superfamily, member 6 , apoptosis (APO-1) antigen 1 ( FAS ), member 6 , Fas receptor CD95