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anti-Human p300 Anticorps:
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Human Monoclonal p300 Primary Antibody pour ChIP, EM - ABIN152047
Eckner, Ludlow, Lill, Oldread, Arany, Modjtahedi, DeCaprio, Livingston, Morgan: Association of p300 and CBP with simian virus 40 large T antigen. dans Molecular and cellular biology 1996
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Human Monoclonal p300 Primary Antibody pour FACS, ICC - ABIN151948
Eckner, Yao, Oldread, Livingston: Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. dans Genes & development 1996
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Human Polyclonal p300 Primary Antibody pour DB - ABIN1881299
Zhang, Zhang, Rui, Liu: p300-mediated acetylation stabilizes the Th-inducing POK factor. dans Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Monoclonal p300 Primary Antibody pour ChIP, ICC - ABIN152048
Eckner, Ewen, Newsome, Gerdes, DeCaprio, Lawrence, Livingston: Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. dans Genes & development 1994
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Human Polyclonal p300 Primary Antibody pour ChIP, ICC - ABIN152981
Julien, Carriere, Moreau, Roux: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. dans Molecular and cellular biology 2010
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Human Monoclonal p300 Primary Antibody pour ChIPSeq, ChIP - ABIN2668569
Dallas, Yaciuk, Moran: Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. dans Journal of virology 1997
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Human Monoclonal p300 Primary Antibody pour ELISA, WB - ABIN969098
Stauffer, Chang, Huang, Dunn, Thayer: p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. dans The Journal of biological chemistry 2007
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Human Monoclonal p300 Primary Antibody pour ELISA, WB - ABIN966068
Geiger, Sharma, Kim, Nyborg: The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. dans Molecular and cellular biology 2008
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Human Polyclonal p300 Primary Antibody pour IHC, IP - ABIN152980
Zhang, Vogel, Liu, Topark-Ngarm, Arbogast, Maier, Filtz, Leid: Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation. dans The Journal of biological chemistry 2012
Human Monoclonal p300 Primary Antibody pour IF, IHC (p) - ABIN560748
Wong, Pickard, McCance: p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1). dans PLoS ONE 2010
Data generated with primary human hepatic stellate cells (HSC) supports that stiffness-mediated HSC activation requires p300.
The histone acylation activity of p300 can be activated by pre-existing lysine crotonylation through a positive feedback mechanism.
epigenomic profiling of clear cell renal cell carcinoma (Montrer MOK Anticorps) (ccRCC) establishes a compendium of somatically altered cis (Montrer CISH Anticorps)-regulatory elements, uncovering new potential targets including ZNF395 (Montrer ZNF395 Anticorps). Loss of VHL (Montrer VHL Anticorps), a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a (Montrer EPAS1 Anticorps) and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes
Histone acetyltransferase (Montrer HAT Anticorps) EP300 is necessary for the transcription factor SOX2 (Montrer SOX2 Anticorps) activity in basal cells, including for induction of the squamous fate. EP300 copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines.
High expression of EP300 is associated with colorectal cancer.
Transcriptional coactivator p300 gene polymorphism correlates with the development and advancement of diabetic kidney disease. Additionally, the SIRT1 (Montrer SIRT1 Anticorps) gene collaborates with the p300 gene and participates in promoting albuminuria in type 2 diabetes mellitus patients.
These results reveal a novel RTK-AKT (Montrer AKT1 Anticorps)-p300-ADA3 (Montrer TADA3 Anticorps) signaling pathway involved in growth factor-induced cell cycle progression.
Study suggest that both p300 and CREB (Montrer CREB1 Anticorps) are required for the function integrity of HIF-1alpha (Montrer HIF1A Anticorps) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300, CREB (Montrer CREB1 Anticorps) and HIF-1alpha (Montrer HIF1A Anticorps).
These results suggest that EP300 harbors adaptive variants in Tibetans, which might contribute to high-altitude adaptation through regulating NO production.
EP300 plays a major role in the reprogramming events, leading to a more malignant phenotype with the acquisition of drug resistance and cell plasticity, a characteristic of metaplastic breast cancer.
Study in mouse model found that liver stiffness activates hepatic stellate cells differentiation into myofibroblasts, which required nuclear accumulation of p300 (Montrer NOTCH1 Anticorps).
Data (including data from studies in knockout and transgenic mice) suggest that Ep300 and Crebbp (Montrer CREBBP Anticorps) are limiting cofactors for pancreatic islet development (including gene expression regulation and cell proliferation), and hence for postnatal glucose homeostasis, with some functional redundancy. (Ep300 = E1A binding protein p300; Crebbp (Montrer CREBBP Anticorps) = CREB binding protein (Montrer CREBBP Anticorps))
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP (Montrer NFAT5 Anticorps) is required for the recruitment of p300 (Montrer NOTCH1 Anticorps). Increased expression of TonEBP (Montrer NFAT5 Anticorps) enhances the NFkappaB activity and reduced TonEBP (Montrer NFAT5 Anticorps) expression lowers it.
Enhancer-priming by MLL3/MLL4 (Montrer MLL4 Anticorps) followed by enhancer-activation by CBP/p300 (Montrer CREBBP Anticorps) sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS (Montrer TLR4 Anticorps) induces endoplasmic reticulum (ER) stress and P300 (Montrer NOTCH1 Anticorps) activity via the XBP1 (Montrer XBP1 Anticorps)/IRE1 (Montrer ERN1 Anticorps) pathway.
Loss of p300 (Montrer NOTCH1 Anticorps) expression is associated with leukemogenesis.
UTX (Montrer KDM6A Anticorps)-MLL4 (Montrer MLL4 Anticorps)-p300 (Montrer NOTCH1 Anticorps) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (Montrer CREBBP Anticorps) and HDAC1-HDAC2 (Montrer HDAC1 Anticorps) has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (Montrer PRMT1 Anticorps) activity was necessary for c-Myc (Montrer MYC Anticorps) binding to acetyltransferase p300 (Montrer NOTCH1 Anticorps) in myeloid cells; Prmt1 (Montrer PRMT1 Anticorps) inhibition decreases p300 (Montrer NOTCH1 Anticorps) recruitment to c-Myc (Montrer MYC Anticorps) target promoters and increased Hdac1 (Montrer HDAC1 Anticorps) recruitment. [Prmt1 (Montrer PRMT1 Anticorps), protein arginine N-methyltransferase 1 (Montrer PRMT1 Anticorps); c-Myc (Montrer MYC Anticorps) = Proto-Oncogene (Montrer RAB1A Anticorps) Proteins c-myc (Montrer MYC Anticorps); Hdac1 (Montrer HDAC1 Anticorps) = histone deacetylase 1 (Montrer HDAC1 Anticorps)]
In line with the acetyltransferase activity of p300 (Montrer NOTCH1 Anticorps), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (Montrer HDAC3 Anticorps) activity maintains PTGES1 expression by recruiting p300 (Montrer NOTCH1 Anticorps) to its gene
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT