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anti-Mouse (Murine) PAG1 Anticorps:
anti-Rat (Rattus) PAG1 Anticorps:
anti-Human PAG1 Anticorps:
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Human Monoclonal PAG1 Primary Antibody pour FACS, IHC (p) - ABIN94272
Yerly, Ding, Tauzin, van Echten-Deckert, Borisch, Hoessli: The sphingolipid-rich rafts of ALK+ lymphomas downregulate the Lyn-Cbp/PAG signalosome. dans European journal of haematology 2010
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Human Monoclonal PAG1 Primary Antibody pour IHC (p), IP - ABIN94270
Baumgartner, Angelisová, Setterblad, Mooney, Werling, Horejsí, Langsley: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. dans Blood 2003
Show all 5 Pubmed References
Cow (Bovine) Monoclonal PAG1 Primary Antibody pour IHC (p), IP - ABIN269119
Yamashita, Chattopadhyay, Fensterl, Zhang, Sen: A TRIF-independent branch of TLR3 signaling. dans Journal of immunology (Baltimore, Md. : 1950) 2012
our findings illustrate that Cbp (Montrer CREBBP Anticorps) is an important regulator of Csk (Montrer CSK Anticorps) recruitment to the SFK Lyn (Montrer LYN Anticorps) in Eporesponsive erythroid cells.
This study demonstrated that cbp (Montrer CREBBP Anticorps) increase in skeletal muscle in muscle atrophy.
PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
PAG (Montrer PRDX1 Anticorps) can function as both a positive and a negative regulator of mast cell signaling, depending upon the signaling pathway involved. PAG (Montrer PRDX1 Anticorps) is a positive regulator of passive systemic anaphylaxis.
Data show that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain.
Cbp plays a role in adult hematopoietic stem cell homeostasis.
Cbp (Montrer CREBBP Anticorps) down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK (Montrer MAPK1 Anticorps)/PI3K pathways in a subset of cancer cells.
expression of Cbp is downregulated during osteoclast differentiation, consequently inhibiting recruitment of Csk to lipid rafts and keeping c-Src activity high in osteoclasts. findings provide a novel paradigm that controls c-Src activity in osteoclasts.
CBP (Montrer CREBBP Anticorps) plays a role in transiently anchoring Thy-1 (Montrer THY1 Anticorps) to the cytoskeleton.
Low PAG1 expression is associated neuroblastoma (Montrer ARHGEF16 Anticorps).
Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src (Montrer SRC Anticorps) and AKT (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) pathways.
Up-regulated expression of CBP (Montrer CREBBP Anticorps) in Jurkat cells could reduce cell homogeneity and promote cell apoptosis
No association Pag1 mutation with patient with Schizophrenia.
The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation (Montrer BLNK Anticorps) and have a pro-inflammatory effect.
CBP (Montrer CREBBP Anticorps) may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src (Montrer SRC Anticorps).
The inhibitory function of novobiocin in disrupting the HIF1alpha (Montrer HIF1A Anticorps)/p300 (Montrer EP300 Anticorps) complex might be important in tumor cell growth.
siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death.
expression of CBP (Montrer CREBBP Anticorps) gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression.
An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK (Montrer EPHB2 Anticorps), as well as the cyclin D1 (Montrer CCND1 Anticorps) expression, leading to an inhibition of the proliferation ability of tumor cells.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1
, phosphoprotein transmembrane adaptor 1
, phosphoprotein-associated with GEMs
, transmembrane phosphoprotein Cbp
, Csk binding protein
, csk-binding protein
, transmembrane adapter protein PAG
, transmembrane adaptor protein PAG
, phosphoprotein associated with glycosphingolipid microdomains 1
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1-like