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After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC (Montrer FUT1 Kits ELISA)) cycling and induces p53 (Montrer TP53 Kits ELISA)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC (Montrer FUT1 Kits ELISA) self-renewal and accumulation of DNA damage in p53 (Montrer TP53 Kits ELISA) null HSCs.
Our study demonstrates a novel role for ASPP1 and ASPP2 (Montrer TP53BP2 Kits ELISA) in the death of retinal ganglion cells.
Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53 (Montrer TP53 Kits ELISA)-independent manner.
Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC.
Increased expression of p53 (Montrer TP53 Kits ELISA) and ASPP1 and downregulation of iASPP (Montrer PPP1R13L Kits ELISA).
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.
ASPP1/2 interacted with centrosome linker protein (Montrer LAT Kits ELISA) C (Montrer PROC Kits ELISA)-Nap1 (Montrer CEP250 Kits ELISA). Co-depletion of ASPP1 and ASPP2 (Montrer TP53BP2 Kits ELISA) inhibited re-association of C-Nap1 (Montrer CEP250 Kits ELISA) with centrosome at the end of mitosis.
ASPP1 and ASPP2 (Montrer TP53BP2 Kits ELISA) cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 (Montrer TP53 Kits ELISA).
When the Px(T)PxR (Montrer NR1I2 Kits ELISA) motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 (Montrer TP53BP2 Kits ELISA) and iASPP (Montrer PPP1R13L Kits ELISA).
the mRNA expression of ASPP1 and ASPP2 (Montrer TP53BP2 Kits ELISA) was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 (Montrer TP53 Kits ELISA)
ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis.
The ability of ASPP1 to activate YAP (Montrer YAP1 Kits ELISA) results in the decreased expression of LATS2, which lowers the ability of p53 (Montrer TP53 Kits ELISA) to induce p21 (Montrer CDKN1A Kits ELISA), cell-cycle arrest and senescence.
overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F (Montrer E2F1 Kits ELISA) pathway
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
protein phosphatase type 2C alpha 1
, protein phosphatase 1, regulatory (inhibitor) subunit 13B
, apoptosis-stimulating protein of p53, 1
, apoptosis-stimulating of p53 protein 1-like
, apoptosis-stimulating of p53 protein 1
, protein phosphatase 1 regulatory subunit 13B
, transformation related protein 53 binding protein 2
, tumor protein p53 binding protein, 2
, tumor protein p53-binding protein, 2
, apoptosis-stimulating protein of p53