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anti-Human TBX2 Anticorps:
anti-Mouse (Murine) TBX2 Anticorps:
anti-Rat (Rattus) TBX2 Anticorps:
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Human Polyclonal TBX2 Primary Antibody pour ICC, IF - ABIN4358058
Schneider, Scheffer, Bund, Boukhallouk, Lambert, Cotarelo, Pflugfelder, Florin, Spoden: The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs. dans Journal of virology 2013
Show all 2 Pubmed References
Human Monoclonal TBX2 Primary Antibody pour IP, WB - ABIN920597
Jacobs, Keblusek, Robanus-Maandag, Kristel, Lingbeek, Nederlof, van Welsem, van de Vijver, Koh, Daley, van Lohuizen: Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. dans Nature genetics 2000
Tbx2 mediates BMP signal to down-regulate FGF signaling pathway by repressing Flrt3 (Montrer FLRT3 Anticorps) expression for anterior tissue formation.
Results suggest that the negative regulatory loops between BMP/Tbx2 and Gremlin (Montrer GREM1 Anticorps) or Hey1 (Montrer HEY1 Anticorps) are responsible for defining the territory of the pronephric nephron.
Bone morphogenetic protein signaling regulates hepatoblast-like cell differentiation into hepatocytes through tbx2b.
propose here a rather unique role of Med10 (Montrer MED10 Anticorps) in orchestrating cardiac valve formation by mediating Foxn4 (Montrer FOXN4 Anticorps) dependent tbx2b transcription, expression of Has2 (Montrer HAS2 Anticorps) and subsequently proper development of the cardiac jelly
This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates.
CNBP (Montrer CNBP Anticorps) up-regulates tbx2b and smarca5 (Montrer SMARCA5 Anticorps), and down-regulates wnt5b (Montrer WNT5B Anticorps) gene expression.
Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling is both sufficient and required for the induction of BMP4 (Montrer BMP4 Anticorps) and Tbx2b expression in the AVC
In zebrafish, two tbx2 genes are functionally redundant for regulating chamber development, while each gene is required independently for development of the atrioventricular canal.
results uncover an evolutionarily conserved role of Tbx2/3 transcription factors during remodeling of the heart myocardium and highlight the importance of controlling cell proliferation as a driving force of morphogenesis
Flh (Montrer NOTO Anticorps) and Tbx2b regulate separate programs of pineal and parapineal development
TBX-2 functions as an UNC-37 dependent transcriptional repressor
Reduction of SUMOylation enhances the effect of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development, and that repression of a downstream target of TBX-2 depends on SUMOylation.
These results identify NF-Y as an important regulator of tbx-2 function in vivo.
Ce-TBX-2, the TBX2/TBX3 (Montrer TBX3 Anticorps) transcriptional factor homologue of the nematode Caenorhabditis elegans, is involved in olfactory adaptation
TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation.
The analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for blastomere-derived precursors to commit to pharyngeal muscle fate.
In screens for mutants with abnormal HSN (Montrer FSCN1 Anticorps) motor neuron development, we identified the T-box protein TBX-2 as being important for both HSN (Montrer FSCN1 Anticorps) and PHB (Montrer PHB Anticorps) sensory neuron differentiation.
TBX2 is a central component of the PTEN/PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps) signaling pathway deregulation in RMS cells and that targeting TBX2 in RMS tumors may offer a novel therapeutic approach for RMS
this new molecular-grade based on the combination of TBX2 and TBX3 (Montrer TBX3 Anticorps) methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Our results suggest a conserved role of Tbx2-related proteins in cell invasion and metastasis-related processes
Data show that the down-regulation of T-box transcription factor TBX2 by transforming growth factor beta I (TGF-beta1 (Montrer TGFB1 Anticorps)) is mediated by T-box transcription factor TBX3 (Montrer TBX3 Anticorps).
The data suggested that the DNA sequence variants within the TBX2 gene promoter was implicated in the indirect inguinal hernia development as a rare cause.
High TBX2 expression is associated with breast cancer.
High TBX2 expression is associated with non-small cell lung cancer.
TBX2 was a significantly prognostic factor for decreased survival.
deregulated TBX2 serves as an oncogene (Montrer RAB1A Anticorps) in rhabdomyosarcoma
Knocking down TBX2 sensitises the cells to cisplatin by disrupting the ATM (Montrer ATM Anticorps)-CHK2 (Montrer CHEK2 Anticorps)-p53 (Montrer TP53 Anticorps) signalling pathway.
TBX2 is expressed in RPE (Montrer RPE Anticorps) cells both in vivo and in vitro. Specific knockdown of TBX2 in the human RPE (Montrer RPE Anticorps) cell line ARPE-19 leads to an accumulation of cells at G1.
Tbx18 (Montrer TBX18 Anticorps) does not function redundantly with Tbx2 or Tbx20 (Montrer TBX20 Anticorps) in epicardial development.
Tbx2 and Tbx3 (Montrer TBX3 Anticorps) function downstream of Shh (Montrer SHH Anticorps) to maintain pro-proliferative mesenchymal Wnt (Montrer WNT2 Anticorps) signaling.
Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis
Msx1 (Montrer MSX1 Anticorps) and Tbx2 antagonistically regulate Bmp4 (Montrer BMP4 Anticorps) expression during the bud-to-cap stage transition in tooth development.
formation of the neurohypophysis requires Tbx3 (Montrer TBX3 Anticorps) and Tbx2 to sequester the SRY box-containing transcription factor Sox2 (Montrer SOX2 Anticorps) away from a Shh (Montrer SHH Anticorps) forebrain enhancer (SBE2)
We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium.
The identification of TBX2 as a target for PAX3 (Montrer PAX3 Anticorps) provides a key insight into how PAX3 (Montrer PAX3 Anticorps) may contribute to melanoma evolution.
Tbx2-mediated regulation of Cdkn1a (Montrer CDKN1A Anticorps) and Cdkn1b (Montrer CDKN1B Anticorps) represents a crucial node in the network integrating patterning information and cell cycle regulation that underlies growth, differentiation, and branching morphogenesis of this organ.
an unanticipated link between TBX2 deregulation in cancer and the acquisition of EMT (Montrer ITK Anticorps) and invasive features of epithelial tumor cells.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
T-Box protein 2
, T-box transcription factor TBX2-A
, T-box protein 2-A
, T-box transcription factor Tbx2
, T-box gene C
, T-box protein 2b
, T-box transcription factor TBX2b
, T-box 2
, T-box transcription factor 2
, T-box transcription factor TBX2-like
, T-box transcription factor TBX2
, T-box 2 protein
, T-box protein 2
, T-box 2 transcription factor