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anti-Human AKT Anticorps:
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Human Polyclonal AKT Primary Antibody pour IHC, WB - ABIN361978
Kim, Lee, Kim, Bahk: A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. dans Proteomics 2008
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Human Polyclonal AKT Primary Antibody pour CyTOF, FACS - ABIN4900619
Wang, Yue, Kim, Fu, Khuri, Sun: Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. dans Cancer research 2008
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Human Polyclonal AKT Primary Antibody pour IHC, WB - ABIN362584
Bahk, Cho, Kim: A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts. dans Biochemical and biophysical research communications 2008
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Human Monoclonal AKT Primary Antibody pour IHC, IHC (p) - ABIN252685
Luty, Rodeberg, Parness, Vyas: Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. dans Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Monoclonal AKT Primary Antibody pour ICS - ABIN1177030
Prinz, Mendler, Masouris, Durner, Oberneder, Noessner: High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention. dans Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Polyclonal AKT Primary Antibody pour IP, WB - ABIN223018
Artwohl, Muth, Kosulin, de Martin, Hölzenbein, Rainer, Freudenthaler, Huttary, Schmetterer, Waldhäusl, Baumgartner-Parzer: R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. dans American journal of physiology. Endocrinology and metabolism 2007
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Human Monoclonal AKT Primary Antibody pour WB - ABIN4279016
Nair, Shishodia, Ahn, Kunnumakkara, Sethi, Aggarwal: Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. dans Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Polyclonal AKT Primary Antibody pour IF, IHC - ABIN361980
Tremblay, Krebs, Dombrowski, Brehm, Bernroider, Roth, Nowotny, Waldhäusl, Marette, Roden: Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. dans Diabetes 2005
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Human Polyclonal AKT Primary Antibody pour IHC, WB - ABIN362586
Xu, Stippec, Lazrak, Huang, Cobb: WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. dans The Journal of biological chemistry 2005
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Human Monoclonal AKT Primary Antibody pour ICS - ABIN1177033
De Falco, Avitabile, Totta, Straino, Spallotta, Cencioni, Torella, Rizzi, Porcelli, Zacheo, Di Vito, Pompilio, Napolitano, Melillo, Capogrossi, Pesce: Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. dans Journal of cellular and molecular medicine 2010
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Studies indicate the role of the insulin-like growth factor 1 (IGF1 (Montrer IGF1 Anticorps)) - phosphoinositide 3-kinase (PI3K (Montrer PIK3CA Anticorps))-Akt signaling pathway in regulating exercise-induced physiological cardiac hypertrophy and cardiac protection [Review].
The ectopic overexpression of miR-379 inhibited cell migration, invasion and EMT progress, while downregulated miR-379 reversed the effect. In addition, miR-379 regulated the focal adhesion kinase (FAK) by directly binding to its 3'-UTR, resulting in suppression of AKT signaling. In clinical samples of gastric cancer (GC), miR-379 inversely correlated with FAK, which was upregulated in GC.
Building upon previous work suggesting that FAK (Montrer PTK2 Anticorps)-Akt1 binding is mediated by the FAK (Montrer PTK2 Anticorps) F1 lobe, we demonstrated that independently expressing the F1 domain in human Caco-2 or murine CT-26 (Montrer DDX53 Anticorps) colon cancer cells by transient or stable inducible plasmid expression respectively prevents the stimulation of cancer cell adhesion by increased extracellular pressure.
These data demonstrated that the knockdown of BZW2 (Montrer BZW2 Anticorps) suppresses protein phosphorylation in the Akt/mTOR (Montrer FRAP1 Anticorps) signaling pathway. These observations suggest that BZW2 (Montrer BZW2 Anticorps) is upregulated and has a pro-tumor effect in osteosarcoma via activation of the Akt/mTOR (Montrer FRAP1 Anticorps) signaling pathway and thus is a potential target for gene therapy.
Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation.
In conclusion, the authors demonstrated that AKT activation prevents apoptosis, partly through inhibition of GSK3beta, resulting in pluripotent stem cells survival.
NHE1 (Montrer SLC9A1 Anticorps) and Akt are downregulated in human umbilical vein endothelial cells by tumor microenvironment conditions, more potently than by hypoxia alone. This inhibits endothelial cell migration and growth in a manner likely modulated by the cancer cell secretome.
These results reveal a novel RTK-AKT-p300 (Montrer EP300 Anticorps)-ADA3 (Montrer TADA3 Anticorps) signaling pathway involved in growth factor-induced cell cycle progression.
These first-in-human data potentially qualify AKT1(low) quiescent cancer cells as a non-genetic cell state that persists after neoadjuvant chemotherapy in triple negative breast cancer patients and warrants further study.
Inhibition of Akt signaling during ex vivo priming and expansion gives rise to CD19CAR T cell populations that display comparatively higher antitumor activity
Findings suggest an important role for effector-like memory CD8 (Montrer CD8A Anticorps)(+) T cells in tumor immune surveillance and indicate proto-oncogene (Montrer RAB1A Anticorps) proteins c-akt (Akt) as a key signaling node in the development of protective memory CD8 (Montrer CD8A Anticorps)(+) T-cell responses.
data showed that Klotho (Montrer KL Anticorps) protects Tac (Montrer IL2RA Anticorps)-induced oxidative stress by negatively regulating the PI3K/AKT pathway and subsequently enhancing FoxO3a (Montrer FOXO3 Anticorps)-mediated MnSOD (Montrer SOD2 Anticorps) expression.
findings indicate that simvastatin exerts a protective effect against ionizing radiation-induced damage in the mouse thymus, which may be partially attributed to the activation of the AKT/sirtuin 1 (Montrer SIRT1 Anticorps) pathway.
findings suggested E. faecalis LTA (Montrer LTA Anticorps) may increased macrophages autophagy via inhibiting PI3K/Akt/mTOR (Montrer FRAP1 Anticorps) pathway and this process was Beclin1 (Montrer BECN1 Anticorps) dependent.
LncARSR promotes hepatic lipogenesis via Akt/SREBP-1c (Montrer SREBF1 Anticorps) pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis.
TLR2 confers a pivotal role in allergic airway inflammation via regulating the PI3K/Akt signaling pathway-related autophagy in mice.
Finally, EGCG remarkably inhibited compound 48/80-induced phosphorylation of extracellular signal-regulated kinase (ERK (Montrer EPHB2 Anticorps)) and imiquimod-induced p-AKT in the spinal cord of mice, respectively. Collectively, these results indicated EGCG could be a promising strategy for anti-itch therapy.
both AKT phosphorylation and RAC-dependent membrane ruffling were markedly reduced by depletion of either APPL1 or MYO6. These results place MYO6 and its binding partners at a central nexus in cellular signaling linking actin dynamics at the cell surface and endosomal signaling in the cell cortex.
TXNIP (Montrer TXNIP Anticorps) is a direct substrate of protein kinase B (AKT) and is responsible for mediating AKT-dependent acute glucose influx after growth factor stimulation.
The metabolic defects of cycG (Montrer CCNG1 Anticorps) mutant animals are abrogated by a concomitant loss of Wdb, CycG (Montrer CCNG1 Anticorps) presumably influences Akt1 activity at the PP2A (Montrer PPP2R2B Anticorps) nexus; Well rounded (Wrd), another B' subunit of PP2A (Montrer PPP2R2B Anticorps) in Drosophila, binds CycG (Montrer CCNG1 Anticorps) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (Montrer CCNG1 Anticorps) mutants.
Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism.
subtle manipulation of foxo (Montrer FOXO Anticorps) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (Montrer GRIN1 Anticorps) localization, and postsynaptic membrane elaboration
Tsc2 (Montrer TSC2 Anticorps) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (Montrer TSC2 Anticorps) mutants, leading to the hypothesis that Tsc2 (Montrer TSC2 Anticorps) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Thus, activation of STAT3 (Montrer STAT3 Anticorps) and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (Montrer CTNNB1 Anticorps) accumulation and subsequent ovarian E2 production.
Caveolin-1 (Montrer CAV1 Anticorps) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (Montrer TGM2 Anticorps) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (Montrer NFKB1 Anticorps).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (Montrer NOX1 Anticorps), reactive oxygen species, and PI3-kinase (Montrer PIK3CA Anticorps) in stimulated NO release.
PI3K/Akt and p53 (Montrer TP53 Anticorps) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (Montrer NOS3 Anticorps) activation in endothelial cells
These findings highlight novel and essential roles of PFKFB4 (Montrer PFKFB4 Anticorps) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
SCF (Montrer KITLG Anticorps) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (Montrer FRAP1 Anticorps)-FOXO1 (Montrer FOXO1 Anticorps) signaling and suppressing the activation of TLR4 (Montrer TLR4 Anticorps) and/or NOD2 (Montrer NOD2 Anticorps) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (Montrer LRP2 Anticorps) is the sensor that determines whether cells will be protected or injured by albumin (Montrer ALB Anticorps); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (Montrer FNTA Anticorps), which further represses the activity of K(+) channel (Montrer KCNC4 Anticorps) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (Montrer CBL Anticorps)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (Montrer CA2 Anticorps)+)-dependent manner, connecting the Ca(2 (Montrer CA2 Anticorps)+) signal to K(+) uptake through activation of a K(+) channel (Montrer KCNC4 Anticorps).
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (Montrer TP53 Anticorps).
Modulation of pptr-1 affects insulin (Montrer INS Anticorps)/IGF-1 (Montrer IGF1 Anticorps) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (Montrer TRH Anticorps) 350.
Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (Montrer RPS6KB1 Anticorps) (Thr389) and 4E-BP1 (Montrer EIF4EBP1 Anticorps) (Thr37/46) in goat fetal fibroblasts.
findings suggested that the expressions of the cardiac CACNA1C (Montrer CACNA1C Anticorps) were under the CLOCK-BMAL1 (Montrer ARNTL Anticorps) regulation, probably through the PI3K-Akt signal pathway
Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, actin, cytoplasmic 1
, gamma non-muscle actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1