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Human Cyclin A Protein expressed in Wheat germ - ABIN1348430
Touati, Cladière, Lister, Leontiou, Chambon, Rattani, Böttger, Stemmann, Nasmyth, Herbert, Wassmann: Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis. dans Cell reports 2012
Cyclin A2 or E1 alterations define a homogenous entity of aggressive hepatocellular carcinoma (HCC) subgroup.
High CCNA2 expression is associated with hepatocellular carcinoma progression.
Study demonstrates that cyclin A2 interacts with actin and RhoA during mitosis, and that cyclin A2 depletion induces a dramatic decrease in active RhoA in mitosis suggesting that cyclin A2 participation in RhoA activation in late mitosis.
Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes.
the presented evidence suggested that WA can inhibit HCC cell proliferationand tumorigenesis through miR-22-repressed CCNA2, which was at least partially through FXR regulation
Findings suggest that ERK1/2-mediated Cdk2/cyclin A signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
some cancer cells are defective for efficient interaction between p27 and CycA-CDK complex due to qualitative alteration(s)
This study shows that cocaine induces significant increases in both the astrocytic expression of cyclin A2 and the proliferation of primary human astrocytes.
Low CCNA expression is associated with lung cancer progression.
cyclin D1 and other cyclins such as cyclin A regulates DNA integrity through RAD51 interaction with the BRCA2 C-terminal domain
inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins.
An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21, p27-cyclin E,A/Cdk2 pathway.
On analyzing cyclin A and B1 (CCNA and CCNB1) expression, positive staining in 90% cases of PTC were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC.
Study describes a positive feedback loop centred on cyclin A2-Cdk2 inhibition of interphase APC/C-Cdc20 to allow further cyclin A2 accumulation and mitotic entry.
PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression
Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the human cytomegalovirus (HCMV) replication cycle.
HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter.
Results suggest that cyclin A2 overexpression may drive cancer by promoting AKT-dependent proliferation and survival.
We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Meioc-deficient spermatocytes that have initiated synapsis mis-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
cyclin A2 controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation.
hese data suggest that mmu-miR-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin and phospholipase C pathways.
Ccn2 is a regulator of the transition through cytokinesis during terminal erythropoiesis.
Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination.
Data indicate that cyclin A2-depleted epithelial cells adopt a fibroblastic morphology and undergo epithelial to mesenchymal transition (EMT).
The activity of PCTK3 is increased via interaction with cyclin A2 and phosphorylation by PKA.
AMPKalpha1 controlled cyclin A2 transcription mainly through the ATF/CREB element
Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.
Conditional knockout of cyclin A2 or the SHH proliferative target Nmyc in CGNP also resulted in PC neuron dyslamination
decreased miR-124 expression could increase CCNA2 in cell and animal model of HD and is involved in deregulation of cell cycle in STHdh(Q111)/Hdh(Q111) cells
The requirement of cyclin A2 for entry into meiosis I and for sister chromatid segregation in meiosis II in mouse oocytes.
Cyclin A expression confirmed a prolifer-ative response in cirrhotic livers in response to mitogens.
Study suggested that OGP may increase the bone formation in OPG-deficient mice by stimulating MSC proliferation rather than differentiation, and probably by triggering CDK2/cyclin A pathway.
CCN1 is a novel, endogenous "parent compound" for chemotaxis modulation.
an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2/cyclin A2 during early vertebrate development
B-Myb represses SMC elastin gene expression and cyclin A plays a role in the developmental regulation of elastin gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
The two single nucleotide polymorphisms of the CCNA2 gene affect wool density in the Rex rabbit.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, Cyclin A2 (Cyclin A)
, cyclin A1
, cyclin A2