anti-Lapin Cyclin D1 anticorps pour Immunohistochemistry

Recommended Cyclin D1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Cyclin D1 (CCND1) Anticorps
  • BCL1
  • D11S287E
  • PRAD1
  • U21B31
  • AI327039
  • CycD1
  • Cyl-1
  • bcl-1
  • cD1
  • cb161
  • cycd1
  • etID37810.7
  • fb52e01
  • fc45c08
  • fc83a12
  • id:ibd1198
  • wu:fb52e01
  • wu:fc45c08
  • wu:fc83a12
  • ccnd1b
  • prad1
  • ccnd1
  • ccnd1a
  • bcl1
  • d11s287e
  • u21b31
  • CCND1
  • cyclin D1
  • cyclin D1 S homeolog
  • cyclin D1 L homeolog
  • CCND1
  • Ccnd1
  • ccnd1
  • ccnd1.S
  • ccnd1.L
Épitope
N-Term
75
39
24
18
14
12
11
10
9
8
8
6
6
6
5
5
5
5
5
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivité
Boeuf (Vache), Chien, Cobaye, Humain, Souris, Porc, Lapin, Rat (Rattus)
469
238
227
44
21
19
19
16
14
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Hôte
Lapin
324
204
19
4
Clonalité
Polyclonal
Conjugué
Cet anticorp Cyclin D1 est non-conjugé
26
23
15
10
8
5
4
4
4
4
4
4
4
4
4
4
4
4
4
3
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
461
208
126
126
109
109
103
80
51
12
8
8
7
6
5
3
1
1
1
1
Options
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N° du produit ABIN2777893
$ 289.00
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General

Antigène Cyclin D1 (CCND1) Anticorps
Épitope N-Term
(75), (39), (24), (18), (14), (12), (11), (10), (9), (8), (8), (6), (6), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivité Boeuf (Vache), Chien, Cobaye, Humain, Souris, Porc, Lapin, Rat (Rattus)
(469), (238), (227), (44), (21), (19), (19), (16), (14), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Hôte Lapin
(324), (204), (19), (4)
Clonalité
Polyclonal
Conjugué Cet anticorp Cyclin D1 est non-conjugé
(26), (23), (15), (10), (8), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(461), (208), (126), (126), (109), (109), (103), (80), (51), (12), (8), (8), (7), (6), (5), (3), (1), (1), (1), (1)
Pubmed 1 référence disponible
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Détail du produit anti-Cyclin D1 anticorps

Détail du antigène Cyclin D1 Information d'application Stockage References for anti-Cyclin D1 antibody (ABIN2777893) Images
Blocking Peptide Blocking peptide for this product available: ABIN974600
Séquence KCEEEVFPLA MNYLDRFLSL EPVKKSRLQL LGATCMFVAS KMKETIPLTA
Homologie Cow: 100%, Dog: 92%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 92%, Rat: 92%
Attributs du produit This is a rabbit polyclonal antibody against CCND1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogène The immunogen is a synthetic peptide directed towards the N terminal region of human CCND1

Détail du antigène Cyclin D1

Détail du produit anti-Cyclin D1 anticorps Information d'application Stockage References for anti-Cyclin D1 antibody (ABIN2777893) Images Haut de la page
Antigène
Autre désignation CCND1 (CCND1 Antibody Extrait)
Sujet CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BCL1, D11S287E, PRAD1, U21B31
Protein Interaction Partner: CDKN1B, CDKN1A, CDK4, RELA, FBXO31, UBC, FBXO4, CAMK1, TP73, RB1, CDK2, HSPA8, POLR1B, MCM10, ORC4, LPL, BRINP1, CDK6, RABEP1, CARD11, CUL1, RBL2, UBTF, CCND1, ATF2, CDKN2A, FBXW8, BTRC, PPP1CC, PPP1CB, PSMA6, ITLN1, MCM7, MCM6, MCM3, MCM2, ELAVL1, PCNA,
Protein Size: 295
Poids moléculaire 34 kDa
ID gène 595
NCBI Accession NM_053056, NP_444284
UniProt P24385
Pathways Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling

Information d'application

Détail du produit anti-Cyclin D1 anticorps Détail du antigène Cyclin D1 Stockage References for anti-Cyclin D1 antibody (ABIN2777893) Images Haut de la page
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 295 AA

Restrictions For Research Use only

Stockage

Détail du produit anti-Cyclin D1 anticorps Détail du antigène Cyclin D1 Information d'application References for anti-Cyclin D1 antibody (ABIN2777893) Images Haut de la page
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Cyclin D1 antibody (ABIN2777893)

Détail du produit anti-Cyclin D1 anticorps Détail du antigène Cyclin D1 Information d'application Stockage Images Haut de la page
Background publications

Kibel, Jin, Klim, Luly, A Roehl, Wu, Suarez: "Association between polymorphisms in cell cycle genes and advanced prostate carcinoma." dans: The Prostate, Vol. 68, Issue 11, pp. 1179-86, 2008

Images

Détail du produit anti-Cyclin D1 anticorps Détail du antigène Cyclin D1 Information d'application Stockage References for anti-Cyclin D1 antibody (ABIN2777893) Haut de la page
Supplier Images
Immunohistochemistry (IHC) image for anti-Cyclin D1 (CCND1) (N-Term) antibody (ABIN2777893) anti-Cyclin D1 (CCND1) (N-Term) antibody