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anti-Human FOXO1 Anticorps:
anti-Rat (Rattus) FOXO1 Anticorps:
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Human Polyclonal FOXO1 Primary Antibody pour ICC, IF - ABIN250693
Hoekstra, Sefton, Berry, Lu, Hardt, Marsh, Yin, Clardy, Chakravarti, Bulun, Kim: Progestins activate the AKT pathway in leiomyoma cells and promote survival. dans The Journal of clinical endocrinology and metabolism 2009
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Human Polyclonal FOXO1 Primary Antibody pour IHC - ABIN966149
Zhao, Gan, Pan, Kan, Majeski, Adam, Unterman: Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. dans The Biochemical journal 2004
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Human Polyclonal FOXO1 Primary Antibody pour IF, IHC - ABIN362088
Zhan, Wang, Li, Xu, Sun, Xu: Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats. dans Journal of neurochemistry 2010
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Human Polyclonal FOXO1 Primary Antibody pour IHC (fro), IF - ABIN4948288
Sajan, Ivey, Lee, Mastorides, Jurczak, Samuels, Shulman, Braun, Leitges, Farese: PKC? haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. dans Molecular endocrinology (Baltimore, Md.) 2014
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Human Polyclonal FOXO1 Primary Antibody pour IHC - ABIN966148
Gan, Zheng, Chabot, Unterman, Quirion: Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. dans Journal of neurochemistry 2005
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Human Monoclonal FOXO1 Primary Antibody pour ICC, IHC - ABIN969521
Lau, Koty, Nalbantoglu: Differential response of glioma cells to FOXO1-directed therapy. dans Cancer research 2009
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Human Polyclonal FOXO1 Primary Antibody pour ICC, IF - ABIN4312363
Sahu, Laakso, Ovaska, Mirtti, Lundin, Rannikko, Sankila, Turunen, Lundin, Konsti, Vesterinen, Nordling, Kallioniemi, Hautaniemi, Jänne: Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. dans The EMBO journal 2011
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Human FOXO1 Primary Antibody pour IHC - ABIN966146
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. dans The Journal of cell biology 2005
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Human Polyclonal FOXO1 Primary Antibody pour IF (p), IHC (p) - ABIN684748
Li, Qiu, Liu, Wang, Hu, Gan, Wang: Long-term thermal manipulation in the late incubation period can inhibit breast muscle development by activating endoplasmic reticulum stress in duck (Anasplatyrhynchos domestica). dans Journal of thermal biology 2017
Human Polyclonal FOXO1 Primary Antibody pour IF (p), IHC (p) - ABIN684733
Lowther, Goods, Lucca, Lerner, Raddassi, van Dijk, Hernandez, Duan, Gunel, Coric, Krishnaswamy, Love, Hafler: PD-1 marks dysfunctional regulatory T cells in malignant gliomas. dans JCI insight 2016
the present study demonstrated that the expression of miR (Montrer MLXIP Anticorps)-196a in human liver cancer cells was upregulated; downregulation of miR (Montrer MLXIP Anticorps)-196a regulated human liver cancer cell biological functions which could benefit the clinical therapy of human liver cancer in the future
Inhibition of FOXO1 enhanced angiogenesis in human bio-engineered capillaries, and resulted in microvascular regeneration and improved function in mouse models of injury-repair.
Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3 (Montrer PAX3 Anticorps)-FOXO1-occupied super enhancers. Furthermore, PAX3 (Montrer PAX3 Anticorps)-FOXO1 recruits and requires the BET bromodomain protein BRD4 (Montrer BRD4 Anticorps) to function at super enhancers, resulting in a complete dependence on BRD4 (Montrer BRD4 Anticorps) and a significant susceptibility to BRD inhibition
FOXO1 silencing also augmented the migratory behavior of SW-13 cells (p<0.0001), suggesting distinct roles for FOXO1 in promoting viability and controlled motility of adrenocortical cells.
the miRNA-223can maintain cell proliferation of breast cancer cell through targeting FOXO 1.
MEG3 (Montrer FAM129B Anticorps) acts as a ceRNA to regulate expression of E-cadherin (Montrer CDH1 Anticorps) and FOXO1 by competitively binding miR (Montrer MLXIP Anticorps)-9 and may be used as a potential biomarker in predicting ESCC patients' progression and prognosis
These results strongly suggest that AMPK (Montrer PRKAA1 Anticorps) can activate ORP150 (Montrer HYOU1 Anticorps) through FOXO1 pathway and confer protection against endoplasmic reticulum stress - induced apoptosis of airway epithelial cells following exposure to cigarette smoke extract.
LAT1 (Montrer LAT Anticorps)-NAD+-SIRT1 (Montrer SIRT1 Anticorps) signaling is activated in tumor tissues of patients with non-small cell lung cancer; NAD+ synthesis regulates the SIRT1 (Montrer SIRT1 Anticorps)-FOXO1 apoptotic pathway in response to NQO1 (Montrer NQO1 Anticorps)
Knockdown of FOXO4 (Montrer FOXO4 Anticorps) but not FOXO1 expression decreased proteasome activity. Following neural differentiation, the HD-iPSC-derived neural progenitor cells (NPCs) demonstrated lower levels of proteasome activity and FOXO (Montrer FOXO3 Anticorps) expressions than their WT counterparts. More importantly, overexpression of FOXO4 (Montrer FOXO4 Anticorps) but not FOXO1 in HD NPCs dramatically enhanced proteasome activity.
The borders of this novel topologically associating domains (TADs)correspond to the original 5'- and 3'- borders of the PAX3 (Montrer PAX3 Anticorps) and FOXO1 TADs, respectively, suggesting that TAD (Montrer CRTAM Anticorps) organisation precedes the formation of regulatory long-range interactions. Our results demonstrate that, upon translocation, novel regulatory landscapes are formed allowing new intra-TAD (Montrer CRTAM Anticorps) interactions between the original loci involved
These results indicate that miR (Montrer MYLIP Anticorps)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (Montrer GAS6 Anticorps) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (Montrer AKT1 Anticorps)-dependent inactivation of FOXO1a.
Authors found that the repress effect of alphaMSH (Montrer POMC Anticorps) in adipocytes apoptosis is acting through Foxo1/mTORC2 (Montrer CRTC2 Anticorps) pathway. These findings indicate that, alphaMSH (Montrer POMC Anticorps) has a strong inhibitory effect on ROS (Montrer ROS1 Anticorps)-induced adipocyte apoptosis and underlying mechanism is interacting with key factors in mTOR (Montrer FRAP1 Anticorps) signal pathway.
Sirt3 (Montrer SIRT3 Anticorps) activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1, which in turn alleviates myocardial hypertrophy.
The data reveal a novel mechanism in which the elevated miR (Montrer MLXIP Anticorps)-425 in IBD mediates pathogenic Th17 cell generation through down-regulation of Foxo1.
we found that in db/db (Montrer LEPR Anticorps) VSMC, the occupancy in promoter regions of inflammatory genes by FOXO1 was reduced.miR-135a increased the inflammatory responses of VSMC involved in complications of vascular diseases by downregulating the expression of FOXO1.
Trehalose may rescue against insulin (Montrer INS Anticorps) resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK (Montrer MAPK14 Anticorps) and Foxo1 without affecting phosphorylation of Akt (Montrer AKT1 Anticorps).
FoxO1 is a key mediator involved in glucose homeostasis and indicate that 1,25(OH)2D3 improves glucose metabolism and bone development
Data show that the mitochondrial enriched GCN5 (Montrer KAT2A Anticorps)-like 1 protein (GCN5L1 (Montrer BLOC1S1 Anticorps)) controls hepatic glucose production by regulating FoxO1 protein levels.
Setdb1 (Montrer SETDB1 Anticorps) regulates PTEN/AKT (Montrer AKT1 Anticorps)/FOXO1 pathway to inhibit Spermatogonial stem cells apoptosis.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (Montrer AKT1 Anticorps)-FoxO1 but not p38 MAPK (Montrer MAPK14 Anticorps) or Erk1/2 MAPK (Montrer MAPK1 Anticorps) pathways.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (Montrer AKT1 Anticorps)-mTOR (Montrer FRAP1 Anticorps)-FOXO1 signaling and suppressing the activation of TLR4 (Montrer TLR4 Anticorps) and/or NOD2 (Montrer NOD2 Anticorps) signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (Montrer MAP3K1 Anticorps) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (Montrer MYLIP Anticorps)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (Montrer MYLIP Anticorps)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (Montrer MYH7 Anticorps) negatively and MyHC IIx and MyHC IIb (Montrer MYH4 Anticorps) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (Montrer TNFSF10 Anticorps) and Fas ligand FasL (Montrer FASL Anticorps) expression during follicular atresia.
Data show that IL-4 (Montrer IL4 Anticorps) induces upregulation of the junction protein claudin-5 (Montrer CLDN5 Anticorps) in endothelial cells (ECs) through activation of Jak (Montrer JAK3 Anticorps)/STAT6 (Montrer STAT6 Anticorps) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (Montrer CEBPB Anticorps) regulate preadipocyte adipogenesis possibly through C/EBPb (Montrer CEBPB Anticorps)-> FoxO1-> C/EBPb (Montrer CEBPB Anticorps) feedback regulatory loop and FoxO1-C/EBPb (Montrer CEBPB Anticorps) protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
concluded that PI 3 (Montrer PI3 Anticorps)-kinase and Akt (Montrer AKT1 Anticorps) are activated after renal ischemia/reperfusion and that Akt (Montrer AKT1 Anticorps) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (Montrer FOXO3 Anticorps), which may affect epithelial cell fate in acute renal failure.
FoxO1a can regulate p27kip nuclear localization
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (Montrer SIRT1 Anticorps) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (Montrer FOXO3 Anticorps) is a key regulator of ROS (Montrer ROS1 Anticorps)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (Montrer NCAM1 Anticorps)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (Montrer TNF Anticorps) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (Montrer SOD1 Anticorps) and catalase (Montrer CAT Anticorps) mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like