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these data demonstrate that miR (Montrer MLXIP Protéines)-130b represses vascular inflammation via targeting Tpl2
Results show that the binding of miR (Montrer MLXIP Protéines)-589-5p to the MAP3K8 3'-UTR inhibits MAP3K8 expression and suppresses CD90 (Montrer THY1 Protéines)+ cancer stem cells characteristics in hepatocellular carcinoma.
RelAp43 interacts with the p105 (Montrer CDH13 Protéines)-ABIN2 (Montrer TNIP2 Protéines)-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein (Montrer MYOM2 Protéines).
miRNA-509-3p mimics or inhibitor transfection tests in KGN cells further confirmed that miRNA-509-3p improved oestradiol (E2) secretion by inhibiting the expression of MAP3K8
role of p105 (Montrer CDH13 Protéines)/Tpl2 signaling in lung homeostasis
rs1042058 GG Crohn's disease -risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying Pattern recognition receptor -initiated outcomes.
MAP3K8 is a direct target of miR (Montrer MLXIP Protéines)-144-3p, and miR (Montrer MLXIP Protéines)-144-3p downregulation is a factor in renal cell carcinoma (Montrer MOK Protéines) progression through potentiation of MAP3K8 expression.
Taken together, these results suggest that Cot kinase might play a critical role in Helicobacter pylori type IV secretion apparatus-dependent early IL-8 (Montrer IL8 Protéines) secretion and CagA (Montrer S100A8 Protéines)-dependent late IL-8 (Montrer IL8 Protéines) secretion as an alternative signaling molecule in the Erk (Montrer EPHB2 Protéines) pathway.
Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.
the results of the present study demonstrated that the miR (Montrer MLXIP Protéines)-509-3p RCC (Montrer XRCC1 Protéines) suppressor was a significant regulator of the MAP3K8 oncogene (Montrer RAB1A Protéines), suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma (Montrer MOK Protéines)
Describe spontaneous S. xylosus infection in a genetically modified murine model. S. xylosus infection in Rag1 (Montrer RAG1 Protéines)-/-Tpl2-/- mice correlated with disseminated bacteria and elevated numbers of circulating monocytes.
study to determine whether Tpl2 influences the immune response generated to the extracellular bacterium Citrobacter rodentium, which induces a mixed Th1 (Montrer HAND1 Protéines) and Th17 response; findings confirm the importance of Tpl2 in driving the development of the proinflammatory Th1 (Montrer HAND1 Protéines) lineage as well as promoting IL-17A (Montrer IL17A Protéines) expression and neutrophil recruitment during infection with extracellular bacteria
TPL-2-regulated Ccl24 (Montrer CCL24 Protéines) in CD11c (Montrer ITGAX Protéines)+CD11b (Montrer ITGAM Protéines)+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.
role of p105 (Montrer NEDD9 Protéines)/Tpl2 signaling in lung homeostasis
this study shows that TPL-2 deficiency leads to severe house duct mite-induced airway allergy, when compared with wild-type mice
The kinase TPL2 activates ERK (Montrer EPHB2 Protéines) and p38 (Montrer CRK Protéines) signaling to promote neutrophilic inflammation
TPL2 kinase is a crucial signaling factor in iNKT cells and major mediator of hepatic inflammation.
Taken together this study identified that TPL-2 regulated TH2-mediated inflammation by supporting lipolysis and M2 macrophage activation, preventing TH2 cell expansion and downstream immunopathology and fibrosis.
Map3k8 decreases apoptosis of monocytes and enhances CCR2 (Montrer CCR2 Protéines) expression on Ly6C(high)CD11c (Montrer ITGAX Protéines)(low) monocytes of atherosclerotic ApoE (Montrer APOE Protéines)(-/-) mice fed an high fat diet.
results demonstrate that Tpl2 promotes inflammation in part by constraining FoxP3 (Montrer FOXP3 Protéines) expression and Treg immunosuppressive functions.
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
mitogen-activated protein kinase kinase kinase 8
, Ewing sarcoma transformant
, cot (cancer Osaka thyroid) oncogene
, proto-oncogene c-Cot
, proto-oncogene serine/threoine protein kinase
, tumor progression locus 2
, COT proto-oncogene serine/threonine-protein kinase
, cancer Osaka thyroid oncogene
, cancer Osaka thyroid, oncogene
, mitogen activated protein kinase kinase kinase 8
, serine/threonine-protein kinase cot
, serine/threonine kinase (Tpl-2)