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Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
SIN1 plays an important role in breast cancer.
In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 (Montrer PDCD4 Protéines) protein was downregulated, suggesting that loss of Pdcd4 (Montrer PDCD4 Protéines) might correlate with Sin1 protein level but not mRNA level in colorectal cancer.
SIN1 plays an important role in non-small cell lung cancer; SIN1 is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1, a known element of the mammalian target of rapamycin (Montrer FRAP1 Protéines) complex 2 (mTORC2 (Montrer CRTC2 Protéines)), is required for Interferon-gamma (Montrer IFNG Protéines)-induced phosphorylation and activation of AKT (Montrer AKT1 Protéines) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Intracellular localization of mTORC2 (Montrer CRTC2 Protéines) component, mSin1, contributes to regulation of Akt (Montrer AKT1 Protéines) phosphorylation.
Akt (Montrer AKT1 Protéines) phosphorylates SIN1 at T86, enhancing mTORC2 (Montrer CRTC2 Protéines) kinase activity, which leads to phosphorylation of Akt (Montrer AKT1 Protéines) S473 by mTORC2 (Montrer CRTC2 Protéines), thereby catalyzing full activation of Akt (Montrer AKT1 Protéines).
MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.
mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.
DNA-PKcs (Montrer PRKDC Protéines)-mTORC2 (Montrer CRTC2 Protéines)(SIN1) association is required for UVB-induced Akt (Montrer AKT1 Protéines) Ser (Montrer SIGLEC1 Protéines)-473 phosphorylation and cell survival.
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient lymphangioleiomyomatosis cells.
analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue
data suggest that DNA-PKcs (Montrer PRKDC Protéines)-SIN1 complexation-mediated Akt (Montrer AKT1 Protéines) activation (Ser (Montrer SIGLEC1 Protéines)-473 phosphorylation) is required for mouse osteoblast differentiation
these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.
The phosphorylation of SIN1 by Akt (Montrer AKT1 Protéines) was found to regulate mTORC2 (Montrer CRTC2 Protéines) activity in response to growth factors, revealing topological insights into the Akt (Montrer AKT1 Protéines)/mTOR (Montrer FRAP1 Protéines) signaling network.
Sin1 and mTORC2 (Montrer CRTC2 Protéines) are dispensable for the development and activation of T cells but play a role in nTreg-cell differentiation.
mSIN1 protein mediates SGK1 (Montrer SGK1 Protéines) protein interaction with mTORC2 (Montrer CRTC2 Protéines) protein complex and is required for selective activation of the epithelial sodium channel
MAP kinase (Montrer MAPK1 Protéines)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.
Sin1-mTORC2 (Montrer CRTC2 Protéines) suppresses rag1,2 and il7r (Montrer IL7R Protéines) gene expression through Akt2 (Montrer AKT2 Protéines) in B cells.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.
, Stress-activated protein kinase [SAPK]-interacting protein
, stress-activated map kinase-interacting protein 1
, mitogen-activated protein kinase associated protein 1
, Target of rapamycin complex 2 subunit MAPKAP1
, target of rapamycin complex 2 subunit MAPKAP1-like
, MEKK2-interacting protein 1
, SAPK-interacting protein 1
, TORC2 subunit MAPKAP1
, mitogen-activated protein kinase 2-associated protein 1
, ras inhibitor MGC2745
, stress-activated map kinase interacting protein 1
, stress-activated protein kinase-interacting 1
, target of rapamycin complex 2 subunit MAPKAP1
, mitogen activated protein kinase associated protein 1
, SAPK interacting protein