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anti-Human MTOR Anticorps:
anti-Mouse (Murine) MTOR Anticorps:
anti-Rat (Rattus) MTOR Anticorps:
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Human Polyclonal MTOR Primary Antibody pour IF (p), IHC (p) - ABIN676403
Li, Liu, Wang, Sun, Ding, Sun, Han, Wang: Follistatin could promote the proliferation of duck primary myoblasts by activating PI3K/Akt/mTOR signalling. dans Bioscience reports 2014
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Human Polyclonal MTOR Primary Antibody pour ELISA, EM - ABIN153493
Gupta, Dillon, Ziesmer, Feldman, Witzig, Ansell, Cerhan, Novak: A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. dans Blood 2009
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Human Polyclonal MTOR Primary Antibody pour ICC, IF - ABIN151707
Bolster, Vary, Kimball, Jefferson: Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. dans The Journal of nutrition 2004
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Human Polyclonal MTOR Primary Antibody pour DB - ABIN1881353
Dowling, Zakikhani, Fantus, Pollak, Sonenberg: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. dans Cancer research 2007
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Human Polyclonal MTOR Primary Antibody pour IHC (p), WB - ABIN272127
Li, Yan, Zhang, Jiang, Sun, Hu, Sun, Xu: miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. dans FEBS letters 2013
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Human MTOR Primary Antibody pour IHC - ABIN966602
Holz, Blenis: Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. dans The Journal of biological chemistry 2005
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Human Polyclonal MTOR Primary Antibody pour IF (p), IHC (p) - ABIN747158
Yang, Wang, Wang, Zhang, Zhang, Lu, Wang: mTOR is involved in 17?-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. dans Molecular reproduction and development 2015
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Human Polyclonal MTOR Primary Antibody pour IF, IHC - ABIN362262
Albanell, Dalmases, Rovira, Rojo: mTOR signalling in human cancer. dans Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2007
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Human Polyclonal MTOR Primary Antibody pour IHC, ELISA - ABIN1531910
Luo, Yoneda, Ohmori, Sasaki, Shimbo, Eto, Kato, Miyano, Kobayashi, Sasahira, Chihara, Kuniyasu: Cancer usurps skeletal muscle as an energy repository. dans Cancer research 2014
Human Polyclonal MTOR Primary Antibody pour IF, IHC (p) - ABIN390217
Cao, Dong, Meng, Liu, Liao, Liu: MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3. dans Tumour biology 2015
High mTOR expression is associated with gastric cancer.
The authors demonstrate that, particularly when autophagy is upregulated, varicella-zoster virus inhibits mTOR-mediated late-stage autophagic flux, likely at the point where autophagosomes and lysosomes fuse or where vesicle contents are degraded. Importantly, inhibition of autophagy yields higher varicella-zoster virus titers.
Identification of a functional mTOR targeted multigene signature robustly discriminates between normal prostate tissues, primary tumors, and hormone refractory metastatic samples but is also predictive of cancer recurrence
2-ME reduced the production of CTGF (Montrer CTGF Anticorps) and collagen I in SSc (Montrer CYP11A1 Anticorps) fibroblasts induced by hypoxia through PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/mTOR/HIF-1alpha (Montrer HIF1A Anticorps) signalling and inhibited the proliferation of fibroblasts. These findings suggested that 2-ME could be employed as a promising antifibrotic therapy for SSc (Montrer CYP11A1 Anticorps)
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (Montrer INS Anticorps) activates mTORC2 (Montrer CRTC2 Anticorps) remains poorly defined.
miR33a5p inhibited the proliferation of lung adenocarcinoma cells, enhanced the antitumor effect of celastrol, and improved sensitivity to celastrol by targeting mTOR in lung adenocarcinoma in vitro and in vivo
miR (Montrer MLXIP Anticorps)-181 may be a novel and important regulator of cisplatin-resistant non-small cell lung cancer by serving a role in the regulation of apoptosis, as an established rate-limiting miRNA target.
Evaluation of the potential mechanism demonstrated that TRIM28 (Montrer TRIM28 Anticorps) promoted cervical cancer cell growth by activating the mammalian target of rapamycin (mTOR) signaling pathway. In support of this finding, TRIM28 (Montrer TRIM28 Anticorps)-induced cell proliferation was abolished by treatment with everolimus, a specific mTOR inhibitor
MiR (Montrer MLXIP Anticorps)-101 and mTOR expressions significantly declined in endometrial cancer (EC) tissue.
while mTOR inhibitors restore endocrine sensitivity, CDK4/6 (Montrer CDK4 Anticorps) inhibitors may favor the emergence of estrogen receptor 1 (ESR1 (Montrer ESR1 Anticorps)) mutations resulting in ligand-independent activity of the receptor
The control of cMaf (Montrer MAF Anticorps) expression at the translational level by mTOR regulated the expression of inflammatory genes in response to lipopolysaccharide challenge.
The function of mTOR in epidermal morphogenesis is split between mTORC1 and mTORC2 (Montrer CRTC2 Anticorps). Whereas mTORC1 mainly controls keratinocyte proliferation within the basal layer, early epidermal stratification and differentiation, mTORC2 (Montrer CRTC2 Anticorps) primarily controls cell division orientation and late stage barrier formation of the interfollicular epidermis.
Loss of mTOR in vasoactive intestinal peptide (Montrer Vip Anticorps) neurons displayed erratic circadian behavior and weakened synchronization among cells in the suprachiasmatic nucleus, the master circadian pacemaker.
T1R1 (Montrer TAS1R1 Anticorps)/T1R3 (Montrer TAS1R3 Anticorps) modulates the mTOR pathway to regulate milk protein synthesis in the mouse mammary gland in vivo.
the protein expression levels of mTOR were significantly reduced in spinal cord injury (SCI) neurons, whereas transfection with a miR99b5p inhibitor suppressed the SCIinduced reduction of mTOR.
Adoptive transfer with targeting-mTOR strategy markedly improves neuronal recovery after ONI, supporting the therapeutic potentials of Tregs in acute and chronic neurological disorder
Activation of the mTOR pathway was partially repressed by T1R1 (Montrer TAS1R1 Anticorps) siRNA or SLC7A5 (Montrer SLC7A5 Anticorps)/SLC3A2 (Montrer SLC3A2 Anticorps) inhibitor (BCH (Montrer CHN2 Anticorps), 10 mM), and the combination of these two treatments further repressed the activity of mTOR pathway.
Ggpps (Montrer GGPS1 Anticorps) deletion enhanced Rheb (Montrer RHEB Anticorps) farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation
mTOR is crucial for T-cell accumulation in the GI tract and for establishing local adaptive immunity against pathogens.
Data show that mammalian/mechanistic target of rapamycin (mTOR) perturbation alters the suprachiasmatic nucleus (SCN (Montrer SRI Anticorps)) clock oscillations.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (Montrer ESCO2 Anticorps) cells and supports that normal gene expression and translation requires ESCO2 (Montrer ESCO2 Anticorps) function.
By inhibiting mTOR signaling via Fbxw7 (Montrer FBXW7 Anticorps), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (Montrer TP53 Anticorps).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (Montrer PPARG Anticorps). In summary, PPARg (Montrer PPARG Anticorps) plays an important role in the regulation of IGF-1 (Montrer IGF1 Anticorps) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (Montrer AKT1 Anticorps)-mTOR-FOXO1 (Montrer FOXO1 Anticorps) signaling and suppressing the activation of TLR4 (Montrer TLR4 Anticorps) and/or NOD2 (Montrer NOD2 Anticorps) signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (Montrer PRKAA1 Anticorps)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (Montrer GUCA2B Anticorps) modulates (Na++K+)ATPase (Montrer ATP1A1 Anticorps) in a proximal tubule cells via cGMP/protein kinase (Montrer CDK7 Anticorps) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (Montrer CCND1 Anticorps), and CCNE1 (Montrer CCNE1 Anticorps).
L-Glutamine (Montrer GFPT2 Anticorps) enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (Montrer PTCHD3 Anticorps) cells through activation of the MTOR-RPS6K-RPS6 (Montrer RPS6 Anticorps)-EIF4EBP1 (Montrer EIF4EBP1 Anticorps) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (Montrer MAP1LC3A Anticorps), B and autophagy-associated genes (ATG5 (Montrer ATG5 Anticorps), mTOR, Beclin-1 (Montrer BECN1 Anticorps)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (Montrer GATM Anticorps) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (Montrer ANXA2 Anticorps) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (Montrer SREBF1 Anticorps)/Cyclin D1 (Montrer CCND1 Anticorps) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (Montrer YWHAG Anticorps) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (Montrer JAK2 Anticorps)-STAT5 (Montrer STAT5A Anticorps) and mTOR signaling pathways.
Insulin (Montrer INS Anticorps)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (Montrer IGF1 Anticorps) down-regulated functional IGF-I receptor (Montrer IGF1R Anticorps) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (Montrer IGF1R Anticorps) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (Montrer INS Anticorps), and prolactin (Montrer PRL Anticorps) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 (Montrer TSC2 Anticorps) and activates mTOR and ribosomal protein S6 (Montrer RPS6 Anticorps) kinase (Montrer RPS6KB1 Anticorps) signaling in an AKT (Montrer AKT1 Anticorps)-independent manner
mTOR links IGF-I (Montrer IGF1 Anticorps) and EGF (Montrer EGF Anticorps) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin