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anti-Mouse (Murine) PDK4 Anticorps:
anti-Human PDK4 Anticorps:
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Human Polyclonal PDK4 Primary Antibody pour IF, IHC (p) - ABIN391039
Attia, Connnaughton, Boone, Wang, Elam, Ness, Cook, Park: Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha). dans The Journal of biological chemistry 2010
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Human Polyclonal PDK4 Primary Antibody pour ICC, IF - ABIN446469
Connaughton, Chowdhury, Attia, Song, Zhang, Elam, Cook, Park: Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin. dans Molecular and cellular endocrinology 2010
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Human Polyclonal PDK4 Primary Antibody pour ELISA, WB - ABIN562163
Stenson, Rydén, Steffensen, Wåhlén, Pettersson, Jocken, Arner, Laurencikiene: Activation of liver X receptor regulates substrate oxidation in white adipocytes. dans Endocrinology 2009
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Human Monoclonal PDK4 Primary Antibody pour ELISA - ABIN518762
Harada, Kakuda, Sato, Ikeda, Shimoda, Yamamoto, Inoue, Ohta, Kasashima, Kawashima, Nakanuma: Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. dans Journal of clinical pathology 2014
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Human Polyclonal PDK4 Primary Antibody pour ICC, IF - ABIN446476
Necela, Axenfeld, Serie, Kachergus, Perez, Thompson, Norton: The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes. dans Clinical and translational medicine 2017
Cow (Bovine) Polyclonal PDK4 Primary Antibody pour IHC, WB - ABIN2777592
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. dans Diagnostic microbiology and infectious disease 2006
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In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH (Montrer SAMSN1 Anticorps) via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD (Montrer TSC2 Anticorps).
our results suggest that PDK2 (Montrer PDK2 Anticorps)/4 can be a potential target for the development of pharmacotherapy for the treatment of acute inflammatory pain
Taken together these data support a model where PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest that inhibition of PDHK4 could represent a novel therapeutic strategy to target KRAS mutant colorectal and lung cancers
PDK4 mediates cisplatin-induced acute kidney injury.
Pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 (Montrer FOXO1 Anticorps) in the heart. FoxO1 (Montrer FOXO1 Anticorps) directly regulates Pdk4 transcription in the heart, thereby controlling PDH (Montrer PDP Anticorps) activity and subsequent glucose oxidation rates.
inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1 (Montrer CCNE1 Anticorps), cyclin A2 (Montrer CCNA2 Anticorps), and E2F1 (Montrer E2F1 Anticorps) proteins.
FXR (Montrer NR1H4 Anticorps) may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.
Taken together, our results suggest that LPS (Montrer TLR4 Anticorps) induces PDK4 expression and alters glucose metabolism via the JNK (Montrer MAPK8 Anticorps) pathway.
upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.
PDK2 (Montrer PDK2 Anticorps)/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.
Results show that PDK4-specific 5'UTR (Montrer UTS2R Anticorps) DNA methylation (Montrer HELLS Anticorps) is positively associated with eicosapentaenoic and arachidonic acid in adult males.
it was found that low expression of FAM210B was significantly correlated with decreased survival and enhanced metastasis in vivo and in vitro, and the loss of FAM210B led to an increased mitochondrial respiratory capacity and reduced glycolysis through the downregulation of pyruvate dehydrogenase kinase 4 (PDK4).
Low PDK4 expression is associated with lung tumorigenesis.
Increased PDK4 expression is associated with colon cancer.
We found that PDK4 gene and protein expression was significantly elevated in pulmonary arterial hypertension pericytes and correlated with reduced mitochondrial metabolism, higher rates of glycolysis, and hyperproliferation
Inhibition of CK2 (Montrer CSNK2A1 Anticorps) increased the expression of metabolic regulators, PDK4 and AMPK (Montrer PRKAA1 Anticorps) along with the key cellular energy sensor CREB (Montrer CREB1 Anticorps).
These findings indicate that the TGFbeta (Montrer TGFB1 Anticorps)/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy.
Preoperative carbohydrate supplementation was found to ameliorate postoperative insulin (Montrer INS Anticorps) sensitivity by reducing muscle inflammatory responses and improved insulin (Montrer INS Anticorps) inhibition of FOXO1 (Montrer FOXO1 Anticorps)-mediated PDK4 mRNA and protein expression after surgery.
Temporal and spatial expression analysis indicated that porcine PDK4 gene is highly expressed in skeletal muscle and the highest in neonatal pigs.
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
pyruvate dehydrogenase kinase 4
, pyruvate dehydrogenase kinase, isoenzyme 4
, pyruvate dehydrogenase kinase, isozyme 4
, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
, pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
, pyruvate dehydrogenase kinase isozyme 4
, pyruvate dehydrogenate kinase 4