Aperçu des produits pour anti-PDPK1 (PDPK1) Anticorps

Full name:: anti-3-phosphoinositide Dependent Protein Kinase-1 Anticorps (PDPK1)

Chez www.anticorps-enligne.fr sont 476 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Anticorps de 32 de différents fournisseurs disponibles. De plus, nous expédions PDPK1 Protéines (30) et PDPK1 Kits (25) et beaucoup plus de produits pour cette protéine. Un total de 566 PDPK1 produits sont actuellement listés.

Synonymes:: 3'-phosphoinositide-dependent protein kinase 1, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, 1210, ATP5A, AtPDK1, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, si:zfos-979f1.3, T32M21.110, T32M21_110

afficher tous les anticorps	Gène	GeneID	UniProt
	PDPK1	81745	O55173
	PDPK1	5170	O15530
	PDPK1	18607	Q9Z2A0
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Human Polyclonal PDPK1 Primary Antibody pour IHC - ABIN966816 : Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. dans Molecular and cellular biology 2005 (PubMed)
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Human PDPK1 Primary Antibody pour IHC - ABIN966815 : Chen, Nystrom, Dong, Li, Song, Liu, Quon: Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism. dans Biochemistry 2001 (PubMed)
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Human Monoclonal PDPK1 Primary Antibody pour ICC, FACS - ABIN969347 : Seong, Jung, Kim, Ha: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. dans The Journal of biological chemistry 2007 (PubMed)
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Human Polyclonal PDPK1 Primary Antibody pour WB - ABIN250778 : Ho, Coomber: Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. dans Experimental cell research 2015 (PubMed)
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Human Polyclonal PDPK1 Primary Antibody pour ICC, IF - ABIN250776 : Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. dans The Biochemical journal 2014 (PubMed)
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Human Polyclonal PDPK1 Primary Antibody pour ELISA, WB - ABIN269845 : Sarbassov, Guertin, Ali, Sabatini: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. dans Science (New York, N.Y.) 2005 (PubMed)
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Human Polyclonal PDPK1 Primary Antibody pour IF, IHC - ABIN361882 : Sato, Fujita, Tsuruo: Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. dans The Journal of biological chemistry 2002 (PubMed)
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Human Polyclonal PDPK1 Primary Antibody pour IHC, IHC (p) - ABIN4344572 : Fack, Espedal, Keunen, Golebiewska, Obad, Harter, Mittelbronn, Bähr, Weyerbrock, Stuhr, Miletic, Sakariassen, Stieber, Rygh, Lund-Johansen, Zheng, Gottlieb, Niclou, Bjerkvig: Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. dans Acta neuropathologica 2015 (PubMed)
Human Polyclonal PDPK1 Primary Antibody pour IF (p), IHC (p) - ABIN744668 : Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy. dans Epilepsy research 2015 (PubMed)
Human Polyclonal PDPK1 Primary Antibody pour IF, IHC - ABIN362492 : Lim, Kikani, Wick, Dong: Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. dans Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
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Plus d’anticorps contre PDPK1 partenaires d’interaction

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

miR (Montrer MYLIP Anticorps)-375 directly targeted PDK1 (Montrer PDK1 Anticorps) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

Our experimental results suggested that PDK1 (Montrer PDK1 Anticorps) may promote chondrocyte apoptosis in osteoarthritis via p38 MAPK (Montrer MAPK14 Anticorps) signaling pathway
ATP5G1 (Montrer ATP5G1 Anticorps), ATP5G2 (Montrer ATP5G2 Anticorps), and ATP5G3 (Montrer ATP5G3 Anticorps) of the ATP synthase are not involved in forming the permeability transition pore.
our results offer significant insight into how PIK3CA (Montrer PIK3CA Anticorps) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (Montrer PIK3CA Anticorps)/PDK1 (Montrer PDK1 Anticorps) and TGFb (Montrer TGFB1 Anticorps) signaling in advanced HNSCC patients with PIK3CA (Montrer PIK3CA Anticorps) amplification
Ribociclib, in combination with GSK2334470 or the PI3Kalpha (Montrer PIK3CA Anticorps) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (Montrer PIK3CA Anticorps)-PDK1 (Montrer PDK1 Anticorps) signaling pathway in mediating acquired resistance to CDK4/6 (Montrer CDK4 Anticorps) inhibitors.
Decreased PDK1 (Montrer PDK1 Anticorps) protein expression in A2058 cells.
Together these results indicate a strong potential regulatory role for PDK1 (Montrer PDK1 Anticorps) in OC stimulatory pathways (Akt (Montrer AKT1 Anticorps), ERK (Montrer EPHB2 Anticorps)) and autophagy induction (via mTORC1), which may contribute to the OC phenotype in Paget's disease of bone.
It targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT (Montrer AKT1 Anticorps).
High (Montrer PDK1 Anticorps)ly expressed PDK1 could promote cell invasion and secretion of IL-1beta and IL-6 in human rheumatoid arthritis s (Montrer PDK1 Anticorps)ynovial (Montrer PDK1 Anticorps)MH7A c (Montrer RPS6KA3 Anticorps)ells. Inhib (Montrer RPS6KA3 Anticorps)ition of RSK2 reduced the PDK (Montrer ASF1A Anticorps)1-induced cell invasion and cytokines secretion (Montrer PDK1 Anticorps) in M (Montrer RPS6KA3 Anticorps)H7A cells. In response to TNF-alpha, PDK1 could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB.
In cancer cells resistant to PI3Kalpha (Montrer PIK3CA Anticorps) inhibition, PDK1 (Montrer PDK1 Anticorps) blockade restores sensitivity to these therapies. SGK1 (Montrer SGK1 Anticorps), which is activated by PDK1 (Montrer PDK1 Anticorps), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (Montrer TSC2 Anticorps).
Results suggest that Ser (Montrer SIGLEC1 Anticorps)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (Montrer PDK1 Anticorps)-PKCtheta (Montrer PRKCQ Anticorps);-mediated T cell activation.

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

our results offer significant insight into how PIK3CA (Montrer PIK3CA Anticorps) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 and TGFb (Montrer TGFB1 Anticorps) signaling in advanced HNSCC patients with PIK3CA (Montrer PIK3CA Anticorps) amplification
PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of asymmetric cell division and the Notch (Montrer NOTCH1 Anticorps)-dependent differentiation program.
Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.
PDK1 was highly expressed in synovia of collagen-induced-arthritis mice compared to control. The expressions of PDK1, p-PDK1, RSK2 (Montrer RPS6KA3 Anticorps) and p-RSK2 (Montrer RPS6KA3 Anticorps) were all up-regulated in CIA (Montrer NCOA5 Anticorps) compared with normal. This indicated that PDK1/RSK2 (Montrer RPS6KA3 Anticorps) may participate in inflammatory progress of RA.
PDK1 is required for Ca(2 (Montrer CA2 Anticorps)+)-dependent platelet activation on stimulation of collagen receptor (Montrer ITGA2 Anticorps) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.
In conclusion, we have identified that ARL15 acts as an insulin (Montrer INS Anticorps)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (Montrer IRS1 Anticorps)/PDPK1/AKT (Montrer AKT1 Anticorps) insulin (Montrer INS Anticorps) pathway by interacting with its GAP ASAP2 (Montrer ASAP2 Anticorps) and activating PDPK1. This research may provide new insights into GTPase (Montrer RACGAP1 Anticorps)-mediated insulin (Montrer INS Anticorps) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (Montrer INS Anticorps) sensitizati
Only when suboptimal doses of Akt (Montrer AKT1 Anticorps)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (Montrer NOTCH1 Anticorps) inhibition was seen. We conclude that the Akt (Montrer AKT1 Anticorps) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (Montrer AKT1 Anticorps) signaling.
Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (Montrer NFKB1 Anticorps).
PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.
The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

The authors show that loss of frataxin homolog (fh (Montrer FXN Anticorps)) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2 (Montrer MYEF2 Anticorps)).
PDK1 is also a presynaptic protein, though it is distributed more broadly.
dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (Montrer CDK7 Anticorps) 1, dPDK1

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (Montrer PIK3C3 Anticorps) (PI3K)

Arabidopsis thaliana 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
PDK1 (Montrer PDK1 Anticorps) undergoes autophosphorylation at several sites; mutation of Ser (Montrer SIGLEC1 Anticorps)-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp (Montrer ASIP Anticorps)-167, Thr (Montrer TRH Anticorps)-176, & Thr (Montrer TRH Anticorps)-211
PDK1 (Montrer PDK1 Anticorps) is a potent enhancer of PID (Montrer MTA2 Anticorps) activity.
specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis

PDPK1 profil antigène

Antigen Summary

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.

Alternative names and synonyms associated with PDPK1

3-phosphoinositide dependent protein kinase 1 (PDPK1) anticorps
3-phosphoinositide dependent protein kinase 1 L homeolog (pdpk1.L) anticorps
3-phosphoinositide dependent protein kinase 1 (pdpk1) anticorps
3-phosphoinositide dependent protein kinase-1 (Pdpk1) anticorps
3-phosphoinositide dependent protein kinase 1 (Pdpk1) anticorps
ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) (ATP5G2) anticorps
3-phosphoinositide-dependent protein kinase 1 (LOC100380750) anticorps
pyruvate dehydrogenase kinase, isozyme 1 (pdk1) anticorps
pyruvate dehydrogenase kinase 1 (PDK1) anticorps
Phosphoinositide-dependent kinase 1 (Pdk1) anticorps
3-phosphoinositide-dependent protein kinase 1 (pdk-1) anticorps
pyruvate dehydrogenase kinase 1 (Pdk1) anticorps
3'-phosphoinositide-dependent protein kinase 1 (PDK1) anticorps

3'-phosphoinositide-dependent protein kinase 1 anticorps
3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 anticorps
1210 anticorps
ATP5A anticorps
AtPDK1 anticorps
BG02759 anticorps
CG1201 anticorps
CG1210 anticorps
Dmel\\CG1210 anticorps
dPDK-1 anticorps
dPDK1 anticorps
dSTPK61 anticorps
MGC82080 anticorps
PDK anticorps
PDK-1 anticorps
Pdk1 anticorps
PDK1/Pk61C anticorps
pdpk1 anticorps
PDPK2 anticorps
pk61c anticorps
Pk61C/PDK1 anticorps
PRO0461 anticorps
si:zfos-979f1.3 anticorps
T32M21.110 anticorps
T32M21_110 anticorps

Protein level used designations for PDPK1

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 3-phosphoinositide-dependent protein kinase 1 3-phosphoinositide dependent protein kinase-1 pkB kinase protein kinase B kinase PkB kinase like gene 1 Pkb kinase mPDK1 ATP synthase c subunit ATP synthase lipid-binding protein, mitochondrial ATP synthase proteolipid P2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) ATPase protein 9 ATPase subunit C mitochondrial ATP synthase, subunit C (subunit 9) CG1210-PA CG1210-PB CG1210-PC CG1210-PD CG1210-PE CG1210-PF CG1210-PG CG1210-PH CG1210-PI CG1210-PJ Pdk1-PA Pdk1-PB Pdk1-PC Pdk1-PD Pdk1-PE Pdk1-PF Pdk1-PG Pdk1-PH Pdk1-PI Pdk1-PJ phosphoinositide dependent kinase 1 phosphoinositide-dependent kinase 1 protein kinase 61C serine/threonine protein kinase pyruvate dehydrogenase kinase 1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

GENE ID	SPECIES
416588	Gallus gallus
444529	Xenopus laevis
479875	Canis lupus familiaris
100138102	Bos taurus
100192445	Sus scrofa
779524	Xenopus (Silurana) tropicalis
81745	Rattus norvegicus
5170	Homo sapiens
18607	Mus musculus
517	Homo sapiens
100380750	Salmo salar
555840	Danio rerio
100064091	Equus caballus
38017	Drosophila melanogaster
180475	Caenorhabditis elegans
100351323	Oryctolagus cuniculus
100715937	Cavia porcellus
101117211	Ovis aries musimon
830330	Arabidopsis thaliana

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