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data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation.
PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma.
expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways.
Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis.
p101 has a role in membrane recruitment and activation of PI3K gamma
analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma
Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
PI3-kinase regulatory subunit 5
, phosphoinositide-3-kinase, regulatory subunit 5, p101
, PI3-kinase p101 subunit
, phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
, phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit
, phosphoinositide 3-kinase regulatory subunit 5
, protein FOAP-2
, ptdIns-3-kinase p101
, Phosphoinositide 3-kinase regulatory subunit 5
, IB PI3-kinase p101 subunit
, ptdIns-3-kinase regulatory subunit