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oocyte-specific deletion of Ppp2r1a led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (Protein Phosphatase 2A(Twins)) counteracts Plk4 (Montrer PLK4 Kits ELISA) autophosphorylation, thus stabilizing Plk4 (Montrer PLK4 Kits ELISA) and promoting centriole duplication
PP2A-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (Montrer TFAP2A Kits ELISA), CREB (Montrer CREB1 Kits ELISA), ETS-1 (Montrer ETS1 Kits ELISA), and SP-1 (Montrer SP1 Kits ELISA)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A prevents the inhibitory function of CTLA-4 (Montrer CTLA4 Kits ELISA), before TCR-CTLA-4 (Montrer CTLA4 Kits ELISA) coligation.
PP-2A regulation of paxillin (Montrer PXN Kits ELISA) phosphorylation may have a role in controlling tumor cell adherence and motility.
PP2A may contribute to melanoma cell radioresistance: the truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 (Montrer MDM2 Kits ELISA) phosphorylation
PP2A has a fundamental role in cardiac function
PPP2R1A mutations occur in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential that leads to decreased disease-free survival and overall survival
Results demonstrated that the promotive effect of eEF-2K on glycolysis resulted from the kinase-mediated restriction of synthesis of the protein phosphatase 2A-A (PP2A-A).
PPP2R1A mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis.
PPP2R1A mutations affect PP2A function and oncogenic signaling, illuminating the genetic basis for serous EC development.
PR65A phosphorylation regulates PP2A complex signaling.
Our results suggest that IH-induced ROS (Montrer ROS1 Kits ELISA) generation increases PP2A (Montrer PPP2R4 Kits ELISA) activation and subsequently downregulates ERK1/2 (Montrer MAPK1/3 Kits ELISA) activation, which results in inhibition of PC12 cell proliferation through G0/G1 phase arrest and NGF (Montrer NGFB Kits ELISA)-induced neuronal differentiation.
The two functional variants in PPP2R1A and PPP2R5E (Montrer PPP2R5E Kits ELISA) and their combinations are associated with lung cancer risk in the Chinese.
Partial unfolding of PR65/A impacts catalysis by altering the proximity of bound catalytic subunit and substrate.
For PPP2R1A, a heterozygous, somatic mutation (c.771G>T, p.W257C) was identified in 1 out of 37 patients (2.7%) with primary ovarian endometrioid carcinoma.
gene transcription of PPP2R1A regulated by the polymorphism and methylation in the promoter region
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
, platelet-derived growth factor subunit B
, protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
, alpha isoform of regulatory subunit A, protein phosphatase 2
, protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform
, protein phosphatase 2, regulatory subunit A, alpha
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like
, PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
, medium tumor antigen-associated 61 KDA protein
, serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
, medium tumor antigen-associated 61 kDa protein
, protein phosphatase 2A 65 kDa regulatory subunit, alpha isoform