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Human PPP2R1A Protein expressed in Wheat germ - ABIN1316014
Lao, Yusoff, Chandramouli, Philp, Fong, Jackson, Saw, Yu, Guy: Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation. dans The Journal of biological chemistry 2007
RAB9 (Montrer RAB9A Protéines) competes with the catalytic subunit PPP2CA (Montrer PPP2CA Protéines) in binding to PPP2R1A. This competitive association has an important role in controlling the PP2A (Montrer PPP2R4 Protéines) catalytic activity.
Total PP2A (Montrer PPP2R4 Protéines) activity and PPP2R1A-associated PP2Ac (Montrer PPP2CA Protéines) activity were significantly increased in cells overexpressing PPP2R1A-WT. In addition, overexpression of PPP2R1A-WT increased cell proliferation in vitro and tumor growth in vivo
PPP2R1A mutations occur in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential that leads to decreased disease-free survival and overall survival
Results demonstrated that the promotive effect of eEF-2K (Montrer EEF2K Protéines) on glycolysis resulted from the kinase-mediated restriction of synthesis of the protein phosphatase 2A-A (PP2A (Montrer PPP2R4 Protéines)-A).
PPP2R1A mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis.
PPP2R1A mutations affect PP2A (Montrer PPP2R4 Protéines) function and oncogenic signaling, illuminating the genetic basis for serous EC development.
PR65A phosphorylation regulates PP2A (Montrer PPP2R4 Protéines) complex signaling.
Our results suggest that IH-induced ROS (Montrer ROS1 Protéines) generation increases PP2A (Montrer PPP2R4 Protéines) activation and subsequently downregulates ERK1/2 activation, which results in inhibition of PC12 cell proliferation through G0/G1 phase arrest and NGF (Montrer NGFB Protéines)-induced neuronal differentiation.
The two functional variants in PPP2R1A and PPP2R5E (Montrer PPP2R5E Protéines) and their combinations are associated with lung cancer risk in the Chinese.
Partial unfolding of PR65/A impacts catalysis by altering the proximity of bound catalytic subunit and substrate.
oocyte-specific deletion of Ppp2r1a led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (Montrer PPP2R2B Protéines) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (Montrer PLK4 Protéines) autophosphorylation, thus stabilizing Plk4 (Montrer PLK4 Protéines) and promoting centriole duplication
PP2A (Montrer PPP2R2B Protéines)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (Montrer TFAP2A Protéines), CREB (Montrer CREB1 Protéines), ETS-1 (Montrer ETS1 Protéines), and SP-1 (Montrer SP1 Protéines)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A (Montrer PPP2R2B Protéines) prevents the inhibitory function of CTLA-4 (Montrer CTLA4 Protéines), before TCR-CTLA-4 (Montrer CTLA4 Protéines) coligation.
PP-2A regulation of paxillin (Montrer PXN Protéines) phosphorylation may have a role in controlling tumor cell adherence and motility.
PP2A (Montrer PPP2R2B Protéines) may contribute to melanoma cell radioresistance: the truncated isoform of the PP2A (Montrer PPP2R2B Protéines) B56gamma regulatory subunit reduces irradiation-induced Mdm2 (Montrer MDM2 Protéines) phosphorylation
PP2A (Montrer PPP2R2B Protéines) has a fundamental role in cardiac function
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, medium tumor antigen-associated 61 KDA protein
, protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
, serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, alpha isoform of regulatory subunit A, protein phosphatase 2
, protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform
, protein phosphatase 2A 65 kDa regulatory subunit, alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
, medium tumor antigen-associated 61 kDa protein
, protein phosphatase 2, regulatory subunit A, alpha
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, protein phosphatase 2 regulatory subunit A, alpha S homeolog