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this study shows the importance of PP2A complexes with the LIM domains of lipoma-preferred partner in cell adhesion and migration dynamics
two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A demonstrating the ability or calcium ions to interact with and regulate PP2A
The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
PP2A (Montrer PPP2R4 Kits ELISA) can be targeted in a calcium-regulated manner to Cdc6 (Montrer CDC6 Kits ELISA) via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability.
PR72 interacts physically and functionally with Naked cuticle. PR72, like Naked cuticle, acts as a negative regulator of the classical Wnt (Montrer WNT2 Kits ELISA) signaling cascade.
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
, protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha
, PP2A B'' subunit PR74
, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
, protein phosphatase 2, regulatory subunit B'', alpha
, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like
, protein phosphatase 2, regulatory subunit (59 kDa)
, protein phosphatase 2, regulatory subunit B, alpha
, protein phosphatase 2A, 59 kDa regulatory subunit B
, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta
, PP2A subunit B isoforms B72/B130
, PP2A, subunit B, R3 isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform
, serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
, DNA for thyroid hormone receptor binding site (258bp)
, alpha isoform of regulatory subunit B'', protein phosphatase 2