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BPGAP1 (Montrer ARHGAP8 Anticorps) provides a crucial spatiotemporal checkpoint where JNK (Montrer MAPK8 Anticorps) and MP1 (Montrer PITRM1 Anticorps)/MEK1 (Montrer MAP2K1 Anticorps) work in concert to regulate endosomal and nuclear ERK (Montrer EPHB2 Anticorps) signaling in cell proliferation control.
Pin1 (Montrer PIN1 Anticorps) regulates BPGAP1 (Montrer ARHGAP8 Anticorps) function in Rho and Erk (Montrer EPHB2 Anticorps) signalling, with active Mek2 (Montrer MAP2K2 Anticorps) serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP (Montrer ARHGAP1 Anticorps), Pin1 (Montrer PIN1 Anticorps) and Erk (Montrer EPHB2 Anticorps) in the regulation of cell migration.
BPGAP1 (Montrer ARHGAP8 Anticorps) has a role in regulating cell dynamics with BNIP-2 (Montrer BNIP2 Anticorps) and Cdc42GAP (Montrer ARHGAP1 Anticorps) homology/Sec14p-like, proline-rich, and GTPase-activating protein (Montrer RASA1 Anticorps) domains of BPGAP1 (Montrer ARHGAP8 Anticorps)
RhoGAP (Montrer ARHGAP1 Anticorps) functionally interacts with cortactin (Montrer CTTN Anticorps) and represents a novel determinant in the regulation of cell dynamics.
ARHGAP8 (Montrer ARHGAP8 Anticorps) expression was up-regulated in the majority of primary colorectal tumors analyzed in this work.
BPGAP1 (Montrer ARHGAP8 Anticorps) is a novel RhoGAP (Montrer ARHGAP1 Anticorps) that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 (Montrer BNIP2 Anticorps) and Cdc42GAP (Montrer ARHGAP1 Anticorps) homology domains.
findings reveal a concomitant activation of endocytosis and ERK (Montrer EPHB2 Anticorps) signaling by BPGAP1 (Montrer ARHGAP8 Anticorps) via the coupling of its proline-rich region, which targets EEN (Montrer SH3GL1 Anticorps) and its functional GAP domain
mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines
It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 (Montrer PRR5L Anticorps) results in the co-immunoprecipitation of other mTORC2 (Montrer CRTC2 Anticorps) subunits, but not Raptor (Montrer RPTOR Anticorps), a specific component of mTORC1.
The inhibition of Akt (Montrer AKT1 Anticorps) and S6K1 (Montrer RPS6KB1 Anticorps) phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (Montrer PDGFRB Anticorps) (PDGFRbeta).
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
BCH domain-containing Cdc42GAP-like protein
, BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1
, rho GTPase-activating protein 8
, rho-type GTPase-activating protein 8
, proline-rich protein 5
, protein observed with Rictor-1
, Rho GTPase activating protein 8
, Protor-2 homolog
, proline rich 5 (renal)
, proline rich protein 5