Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
p54-S6K2 interactome is predominant to the nucleus, whereas p70-S6K1 is predominant to cytosol.
Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency
We propose that the S6K2/TRBP node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR pathway and the miRNA biogenesis machinery.
discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer
Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.
The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer.
The p85 S6K1 promotes H2O2-induced cell death via a rapamycin-insensitive mechanism.
S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis
S6K1 and S6K2 gene amplification was associated with a worse prognosis.
S6K2 expression dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis
Study shows that the two homologues of S6K have distinct effects on Akt activation and cell survivalin breast cancer.
Dysregulation of S6 kinases contributes to the pathogenesis of human diseases.
Data show that genetic variation in RPS6KA1, RPS6KA2, and PRS6KB2 were associated with risk of developing colon cancer while only genetic variation in RPS6KA2 was associated with altering risk of rectal cancer.
heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway
p70 S6 kinase regulates neutrophilic differentiation in HL-60 cells
regulation of nucleocytoplasmic shuttling of S6KbetaII by protein kinase C-mediated phosphorylation
the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells.
These data suggest that activated p70 S6 kinase could mediate an up-regulation of tau translation.
p70 ribosomal protein S6 kinase activity was induced by K-Ras in a phosphatidylinositol 3-kinase and mTOR-dependent manner.
IFNgamma-activated p70 S6 kinase phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation.
S6K2 loss reduces Th17 skewing and increases regulatory T cell differentiation.
the p70S6K isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.
S6K2 regulates hepatic energy homeostasis by repressing PPARalpha activity.
metabolic functions of S6K in vivo play a key role as a molecular interface connecting dietary lipids to the endogenous control of energy metabolism.
Data show that the absence of ribosomal protein S6 kinases 1 and 2 (S6K1 and S6K2) profoundly impairs animal viability but does not seem to affect the proliferative responses of cells derived from the distinct S6K genotypes.
S6K2 is activated by IL-3 in the IL-3-dependent Ba/F3 cell line and this is mediated by mTOR and its upstream activator PI-3K but not by MAPK signal pathways.
parallel increase in p70S6K activation and tau phosphorylation could be demonstrated by treating wild-type N2a cells with Abeta25-35
mGluR-LTD is associated with PI3K-, mTOR-, and ERK-dependent alterations in the phosphorylation of S6 and S6K.
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
70 kDa ribosomal protein S6 kinase 2
, S6 kinase-related kinase
, p70 S6 kinase beta
, p70 S6K-beta
, p70 S6KB
, p70 ribosomal S6 kinase beta
, p70-S6K 2
, ribosomal protein S6 kinase beta-2
, serine/threonine-protein kinase 14 beta
, serine/threonine-protein kinase 14B
, ribosomal protein S6 kinase, 70kDa, polypeptide 2
, S6 kinase 2
, ribosomal protein S6 kinase, 70kD, polypeptide 2