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Data suggest that micoRNA-128 targets the 3prime-untranslated region of nuclear import factor transportin 1 (TNPO1) mRNA.
the TNPO1-Rab8 (Montrer RAB8A Protéines)-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.
Together, these results indicate that transportin-1 mediates YB-1 (Montrer YBX1 Protéines) nuclear translocation.
findings suggest that a new player, i.e., O-GlcNAcylation, regulates hnRNP A1 translocation and interaction with Trn1, possibly affecting its function
Importins, Impbeta, Kapbeta2, Imp4 (Montrer SPPL2B Protéines), Imp5 (Montrer IPO5 Protéines), Imp7 (Montrer IPO7 Protéines), Imp9 (Montrer IPO9 Protéines), and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 (Montrer IPO5 Protéines) with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Results show that Karyopherin-b2 binds to the N-terminal tail of histone H3 (Montrer HIST3H3 Protéines) with high affinity even though H3 lacks a recognizable proline-tyrosine nuclear localization signal (PY-NLS (Montrer ALDH1A2 Protéines)).
FGF2 (Montrer FGF2 Protéines) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (Montrer RAN Protéines) in human glioblastoma cells
Kapbeta2 interacts with ULK2 (Montrer ULK2 Protéines) through ULK2 (Montrer ULK2 Protéines)'s putative PY-NLS (Montrer ALDH1A2 Protéines) motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity.
Studies indicate potential roles of Tranportin-1 and Transportin-2 (Montrer TNPO2 Protéines) beyond protein nuclear import.
ADAR1 (Montrer ADAR Protéines) carries a unique nuclear localization signal (NLS (Montrer ALDH1A2 Protéines)) that overlaps one of its double-stranded RNA-binding domains (dsRBDs). This dsRBD-NLS (Montrer ALDH1A2 Protéines) is recognized by nuclear import receptor transportin 1 (also called karyopherin-beta2) in an RNA-sensitive manner.
Co-immunoprecipitation and affinity-binding studies revealed that Rab23 (Montrer RAB23 Protéines) exists in a complex with Kif17 (Montrer KIF17 Protéines) and importin b2 implying that Kif17 (Montrer KIF17 Protéines) needs to bind to regulatory proteins like Rab23 (Montrer RAB23 Protéines) for its ciliary transport
Association with Tnpo1 is necessary for Oxtr (Montrer OXTR Protéines) nuclear localization. This is required for Oxt (Montrer OXT Protéines)-induced osteoblast differentiation. osteoblast differentiation.
DJ-1 (Montrer PARK7 Protéines) import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (Montrer HTT Protéines) protein.
Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.
Results indicate that TRN1 positively regulates miRNA activity by promoting the association of miRNAs with AGO1 (Montrer EIF2C1 Protéines), and they reveal opposing roles of two importin beta (Montrer KPNB1 Protéines) family proteins in miRNA loading.
Results show that tranportin 1 (AtTRN1) recognizes a broad spectrum of proteins having diverse functions, which will potentially be the cargoes of AtTRN1.
These results suggest that Aqp0a is the primary water channel (Montrer AQP4 Protéines) of the lens and that Aqp0b, though possibly a secondary water channel (Montrer AQP4 Protéines), has an unidentified function in the lens.
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.
M9 region interaction protein
, importin 2
, importin beta 2
, importin beta-2
, karyopherin (importin) beta 2
, karyopherin beta-2
, transportin 1
, myocardial ischemic preconditioning up-regulated protein 1
, myocardial ischemic preconditioning upregulated 1
, major intrinsic protein of lens fiber 1