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Human Angiopoietin 2 Protein expressed in HEK-293 Cells - ABIN2870605
Kang, Kim, Jeong, Im: Angiopoietin-2 Enhances Osteogenic Differentiation of Bone Marrow Stem Cells. dans Journal of cellular biochemistry 2017
Human Angiopoietin 2 Protein expressed in HEK-293 Cells - ABIN1344329
Kim, Shin, Kim, Choi, Byun, Jeon, Suh, Kim: Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells. dans Cardiovascular research 2006
Flunarizine protected ECs from TNFalpha (Montrer TNF Protéines)-induced increase in Angpt-2 transcription and vascular barrier breakdown.
Study findings delineate the existence of the beta-estradiol (E2)-ANGPT2 axis in hair follicles and suggest that, by substituting E2, ANGPT2 may provide a novel strategy for the treatment of postmenopausal female pattern hair loss.
Results suggest that hCPFs-Exo transports low expressed exosomal miR (Montrer MLXIP Protéines)-106b-5p to endothelial cells and promotes angiogenesis by overexpression of Angpt2.
Angpt2 is an independent predictor of adverse clinical outcomes in diabetic patients. Further studies are needed to identify the pathogenic role of Angpt2 in renal deterioration and cardiovascular complications of diabetes mellitus.
High ANG2 expression is associated with Acute respiratory distress syndrome.
PVT1 was able to bind and degrade miR26b to promote connective tissue growth factor (CTGF (Montrer CTGF Protéines)) and angiopoietin 2 (ANGPT2) expression.
Serum Ang-2 may be a useful tumor marker in predicting liver cancer prognosis.
High ANG2 expression is associated with angiogenesis in breast cancer.
Angiopoietin-2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout Tie-2 (Montrer TEK Protéines) receptor engagement.
High Angpt2 and low Angpt1 (Montrer ANGPT1 Protéines) levels were positively associated with abnormal cardiac structure.
At the molecular level NLGN2 (Montrer NLGN2 Protéines) colocalizes with its neuronal partner collibystin, a CDC42 (Montrer CDC42 Protéines) guanine nucleotide exchange factor (Montrer ARHGEF12 Protéines), which is also expressed by endothelial cells and in turn modulates Angiopoietin 2 release.
ANGPT2-TIE2 (Montrer TEK Protéines) signaling is essential for mesenteric lymphatic development.VEPTP (vascular endothelial protein tyrosine phosphatase (Montrer PTPRB Protéines)) determines TIE2 (Montrer TEK Protéines) response to ANGPT2.
Endothelial glycocalyx breakdown is mediated by Angpt-2 in a non-redundant manner.
These results indicate that the Angpt-Tie2 (Montrer TEK Protéines) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (Montrer TEK Protéines) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 in inflammation leads to ANG2 antagonism of Tie2 and initiates a positive feedback loop wherein FOXO1-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Shear stress activated Ang-2 via canonical Wnt signaling in vascular endothelial cells, and Wnt-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (Montrer PIK3CA Protéines)/Akt (Montrer AKT1 Protéines) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (Montrer PIK3CA Protéines)/Akt (Montrer AKT1 Protéines) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, angiopoietin 2
, Angiopoietin-2B (Ang-2B)