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anti-Human AXL Anticorps:
anti-Mouse (Murine) AXL Anticorps:
anti-Rat (Rattus) AXL Anticorps:
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Human Polyclonal AXL Primary Antibody pour BR, CyTOF - ABIN5012837
Gould, Baxi, Schroeder, Peng, Leadley, Peterson, Perrin: Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. dans Journal of thrombosis and haemostasis : JTH 2005
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Human Polyclonal AXL Primary Antibody pour IHC - ABIN965631
Partanen, Mäkelä, Alitalo, Lehväslaiho, Alitalo: Putative tyrosine kinases expressed in K-562 human leukemia cells. dans Proceedings of the National Academy of Sciences of the United States of America 1991
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Human Polyclonal AXL Primary Antibody pour IHC - ABIN965632
OBryan, Frye, Cogswell, Neubauer, Kitch, Prokop, Espinosa, Le Beau, Earp, Liu: axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. dans Molecular and cellular biology 1991
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Mouse (Murine) Monoclonal AXL Primary Antibody pour CyTOF, FACS - ABIN4899408
Fujimori, Grabiec, Kaur, Bell, Fujino, Cook, Svedberg, MacDonald, Maciewicz, Singh, Hussell: The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. dans Mucosal immunology 2015
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Human Monoclonal AXL Primary Antibody pour ELISA, WB - ABIN965629
Rual, Venkatesan, Hao, Hirozane-Kishikawa, Dricot, Li, Berriz, Gibbons, Dreze, Ayivi-Guedehoussou, Klitgord, Simon, Boxem, Milstein, Rosenberg, Goldberg, Zhang, Wong, Franklin, Li, Albala, Lim et al.: Towards a proteome-scale map of the human protein-protein interaction network. ... dans Nature 2005
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Human Monoclonal AXL Primary Antibody pour ELISA, WB - ABIN968973
Budagian, Bulanova, Orinska, Duitman, Brandt, Ludwig, Hartmann, Lemke, Saftig, Bulfone-Paus: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. dans Molecular and cellular biology 2005
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Human Polyclonal AXL Primary Antibody pour IHC, IHC (p) - ABIN4282541
Pinato, Mauri, Lloyd, Vaira, Casadio, Boldorini, Sharma: The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma. dans British journal of cancer 2013
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Human Monoclonal AXL Primary Antibody pour IF, ELISA - ABIN965630
Green, Ikram, Vyas, Patel, Proby, Ghali, Leigh, OToole, Storey: Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. dans British journal of cancer 2006
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Human Monoclonal AXL Primary Antibody pour ICC, ELISA - ABIN968974
Vajkoczy, Knyazev, Kunkel, Capelle, Behrndt, von Tengg-Kobligk, Kiessling, Eichelsbacher, Essig, Read, Erber, Ullrich: Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. dans Proceedings of the National Academy of Sciences of the United States of America 2006
Human Monoclonal AXL Primary Antibody pour RNAi, ELISA - ABIN560017
Ammoun, Provenzano, Zhou, Barczyk, Evans, Hilton, Hafizi, Hanemann: Axl/Gas6/NF?B signalling in schwannoma pathological proliferation, adhesion and survival. dans Oncogene 2014
Findings suggest that METTL3 (Montrer METTL3 Anticorps) plays very important oncogenic roles in ovarian carcinoma development and/or aggressiveness by stimulating AXL translation and EMT (Montrer ITK Anticorps).
Co-expression of CDCP1 (Montrer CDCP1 Anticorps) and AXL is often observed in EGFR (Montrer EGFR Anticorps)-mutation-positive tumors, limiting the efficacy of EGFR (Montrer EGFR Anticorps) TKIs. Co-treatment with EGFR (Montrer EGFR Anticorps) TKI and TPX (Montrer TPO Anticorps)-0005 warrants testing.
This study demonstrates that motility behavior of AXL-expressing tumor cells can be elicited by Gas6 (Montrer GAS6 Anticorps)-bearing apoptotic bodies generated from tumor treatment with therapeutics that produce killing of a portion of the tumor cells present but not all, hence generating potentially problematic invasive and metastatic behavior of the surviving tumor cells
Results show that average methylation in AXL at birth was associated with higher risk for asthma-related phenotypes in childhood, especially wheezing. The effects of average AXL methylation on wheezing symptoms were magnified in girls compared to boys.
we identified YAP (Montrer YAP1 Anticorps)-driven AXL overexpression as a mechanism of resistance to EGFR (Montrer EGFR Anticorps) TKIs in lung cancer cells.
The anti-angiogenic effect of luteolin may be associated with the inhibition of the Gas6 (Montrer GAS6 Anticorps)/Axl pathway and its downstream phosphatidylinositol 3-kinase (PI3K (Montrer PIK3CA Anticorps))/protein kinase B (Akt (Montrer AKT1 Anticorps))/mammalian target of rapamycin (mTOR (Montrer FRAP1 Anticorps)) signaling pathways.
AXL is influenced by p53 (Montrer TP53 Anticorps) status and could cause the emergence of aggressive clones after exposure to chemotherapy in colon and breast cancer
Taken together, these findings suggest that AXL most likely serves as an attachment factor for Zika virus on the cell surface, and that productive infection requires endocytosis and delivery of the virus to acidified intracellular compartments.
serum Axl shows high diagnostic accuracy at early stage hepatocellular carcinoma as well as cirrhosis
AXL is the only relevant Zika virus entry cofactor expressed on fetal endothelial cells, and that when produced in mammalian cells, only Zika virus, but not West Nile virus or dengue virus, can use AXL, because it more efficiently binds Gas6 (Montrer GAS6 Anticorps).
These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.
AXL is not the key receptor for Zika virus infection using an Axl knockout mouse model.
present findings indicate that MafB (Montrer MAFB Anticorps) enhances efferocytosis by regulating Axl expression in RAW264.7 macrophages
Study found that hematopoietic cell-Axl deficiency in Western-type diet-fed Ldlr (Montrer LDLR Anticorps)(-/-) mice does not affect the progression of advanced atherosclerosis or lesional processes associated with TAM (Montrer CCNA1 Anticorps) receptor signaling.
This study demonstrated that the Gas6 (Montrer GAS6 Anticorps)(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.
These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.
GAS6 (Montrer GAS6 Anticorps)-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 (Montrer NLRP3 Anticorps) inflammasome activation.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (Montrer ERH Anticorps) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
activation of receptor tyrosine kinase (Montrer RET Anticorps) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog