Aperçu des produits pour anti-AXL (AXL) Anticorps

Human AXL Receptor tyrosine Kinase (AXL) interaction partners

1. The role of AXL in the esophageal adenocarcinoma cell invasion through upregulation of extracellular acidification, lysosomes peripheral distribution, and exocytosis.

2. Decreased ARL2 expression level was clinically correlated to the higher grades and poorer outcomes of glioma patients. ARL2 overexpression attenuated the proliferation, clone formation, migration, invasive and tumorigenic capabilities of glioma cells by regulating the expression of receptor tyrosine kinase AXL.

3. Axl binds to and phosphorylates TNS2 and that Axl/TNS2/IRS-1 cross-talk may potentially play a critical role in glucose metabolism of cancer cells.

4. AXL expression is regulated by miR-34a.miR-34a regulates dendritic cells activation by targeting AXL.AXL expression is reduced in rheumatoid arthritis CD1c+ dendritic cells.

5. Axl induction during viral infections contributes to maintaining macrophage capacity to engulf apoptotic cells, which may have important consequences for resolution of anti-viral immune responses.

6. Serum soluble AXL is not a helpful biomarker for cardiovascular complications after heart transplantation.

7. miR-34a is an oncogenic miRNA, downregulated in the distinct breast cancer subtypes. It also targets MET and AXL 3'-UTRs in triple-negative breast cancer.

8. identify the receptor tyrosine kinase Axl as a novel target of ZNF224 transcriptional repression activity.

9. Findings suggest that METTL3 plays very important oncogenic roles in ovarian carcinoma development and/or aggressiveness by stimulating AXL translation and EMT.

10. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing.

11. This study demonstrates that motility behavior of AXL-expressing tumor cells can be elicited by Gas6-bearing apoptotic bodies generated from tumor treatment with therapeutics that produce killing of a portion of the tumor cells present but not all, hence generating potentially problematic invasive and metastatic behavior of the surviving tumor cells

12. Results show that average methylation in AXL at birth was associated with higher risk for asthma-related phenotypes in childhood, especially wheezing. The effects of average AXL methylation on wheezing symptoms were magnified in girls compared to boys.

13. we identified YAP-driven AXL overexpression as a mechanism of resistance to EGFR TKIs in lung cancer cells.

14. The anti-angiogenic effect of luteolin may be associated with the inhibition of the Gas6/Axl pathway and its downstream phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.

15. AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy in colon and breast cancer

16. Taken together, these findings suggest that AXL most likely serves as an attachment factor for Zika virus on the cell surface, and that productive infection requires endocytosis and delivery of the virus to acidified intracellular compartments.

17. serum Axl shows high diagnostic accuracy at early stage hepatocellular carcinoma as well as cirrhosis

18. AXL is the only relevant Zika virus entry cofactor expressed on fetal endothelial cells, and that when produced in mammalian cells, only Zika virus, but not West Nile virus or dengue virus, can use AXL, because it more efficiently binds Gas6.

19. Results indicate AXL receptor tyrosine kinase (AXL) as an important mediator of docetaxel resistance in prostate cancer.

20. AXL promotes epithelial cell efferocytosis in a tyrosine kinase-dependent manner.AXL role in AKT-dependent drug resistance.

Mouse (Murine) AXL Receptor tyrosine Kinase (AXL) interaction partners

1. ALX-deficient macrophages have defective microparticle clearance resulting in lung inflammation and injury.

2. These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.

3. AXL is not the key receptor for Zika virus infection using an Axl knockout mouse model.

4. present findings indicate that MafB enhances efferocytosis by regulating Axl expression in RAW264.7 macrophages

5. Study found that hematopoietic cell-Axl deficiency in Western-type diet-fed Ldlr(-/-) mice does not affect the progression of advanced atherosclerosis or lesional processes associated with TAM receptor signaling.

6. This study demonstrated that the Gas6(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.

7. These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.

8. GAS6-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 inflammasome activation.

9. Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.

10. reciprocal activation of Axl and Mer receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

11. Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.

12. Axl, Mertk and Tyro3 receptors are not required for Zika virus entry and infection.

13. Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.

14. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.

15. Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.

16. Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.

17. results establish TAM receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

18. These results suggest that TAM receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.

19. Gas6-induced Axl signaling is a critical driver of pancreatic cancer progression.

20. The results indicate that Axl and Mer receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.

Cow (Bovine) AXL Receptor tyrosine Kinase (AXL) interaction partners

1. activation of receptor tyrosine kinase Axl inhibits the osteogenic differentiation of vascular pericytes.