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anti-Human BDNF Anticorps:
anti-Rat (Rattus) BDNF Anticorps:
anti-Mouse (Murine) BDNF Anticorps:
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Human Polyclonal BDNF Primary Antibody pour WB - ABIN3043096
Shi, Shao, Yuan, Pan, Li: Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. dans Yonsei medical journal 2010
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Mouse (Murine) Polyclonal BDNF Primary Antibody pour IHC (p), WB - ABIN3043798
Li, Xia, Zhang, Wu: S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk. dans PLoS ONE 2011
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Dog (Canine) Polyclonal BDNF Primary Antibody pour IHC, WB - ABIN2777093
Hashimoto, Moriguchi, Yamashita, Mori, Nemoto, Okada, Hori, Noguchi, Kunugi, Ohnishi: Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. dans Neuroscience research 2008
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Human Polyclonal BDNF Primary Antibody pour CyTOF, FACS - ABIN4899237
Xapelli, Bernardino, Ferreira, Grade, Silva, Salgado, Cavadas, Grouzmann, Poulsen, Jakobsen, Oliveira, Zimmer, Malva: Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. dans The European journal of neuroscience 2008
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Human Polyclonal BDNF Primary Antibody pour IHC, IHC (p) - ABIN4283816
Hasan Mahmood, Uddin, Ibrahim, Mandal, Alhamami, Briski et al.: Sex differences in forebrain estrogen receptor regulation of hypoglycemic patterns of counter-regulatory hormone secretion and ventromedial hypothalamic nucleus glucoregulatory neurotransmitter and ... dans Neuropeptides 2018
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Mouse (Murine) Polyclonal BDNF Primary Antibody pour IHC, WB - ABIN3021893
Hang, Zhao, Sun, Li, Han, Du, Li: Brain-derived neurotrophic factor attenuates doxorubicin-induced cardiac dysfunction through activating Akt signalling in rats. dans Journal of cellular and molecular medicine 2017
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Human Polyclonal BDNF Primary Antibody pour DB, IHC (fro) - ABIN542616
Pezet, Malcangio, McMahon: BDNF: a neuromodulator in nociceptive pathways? dans Brain research. Brain research reviews 2003
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Human Polyclonal BDNF Primary Antibody pour IHC, WB - ABIN6672757
Sidler, Aitken, Jiang, Sotiropoulos, Aggarwal, Anees, Chong, Siebenaller, Thanabalasingam, White, Choufani, Weksberg, Sangiorgi, Wrana, Delgado-Olguin, Bägli et al.: DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of ... dans The American journal of pathology 2018
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Human Polyclonal BDNF Primary Antibody pour IF (p), IHC (p) - ABIN1387788
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. dans Neurobiology of disease 2014
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Human Polyclonal BDNF Primary Antibody pour WB - ABIN548503
Jones, Reichardt: Molecular cloning of a human gene that is a member of the nerve growth factor family. dans Proceedings of the National Academy of Sciences of the United States of America 1990
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Results suggest that polymorphisms of single nucleotide polymorphisms (SNP) of brain derived neurotrophic factor (BDNF) play an important role in lifetime cigarette smoking and cigarette smoking within a 12-month period of susceptibility in the Iranian population.
findings from a meta-analytic investigation of published literature provide little support for the Val66Met variant of BDNF as a predictor of obsessive-compulsive disorder; future well-powered agnostic genome-wide association studies with more refined phenotype are needed to clarify genetic influences on OCD
Associations of Gene Variations in Neuropeptide Y and Brain Derived Neurotrophic Factor Genes with Posttraumatic Stress Disorder
This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.
this paper shows a strong and positive correlation between BDNF and its antisense RNA, BDNF-AS in multiple sclerosis patients
Carrying two copies of the rs6265 Met66 allele ( approximately 4% of the population) is associated with less severity in motor symptoms and potentially a slower rate of progression in Parkinson disease.
Our data show that the rs10767664 variant of the BDNF gene modifies insulin resistance and insulin levels after weight loss with a hypocaloric diet enriched with monounsaturated fatty acids (MUFAs).
Separate and combined effects of religiosity, child aggression, and BDNF genotype on mothers' and fathers' use of corporal punishment.
This review showed the Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor on Neurological Function after Traumatic Brain Injury.
Results revealed broad alteration of H3K27me3 and AcH3 marks association profiles in BDNF(Met/Met), compared to BDNF(Val/Val) mice. Bioinformatics analysis showed changes in several biological functions and related pathways, affected by the presence of the polymorphism. In particular, a number of networks of functional interaction contained BDNF as central node.
5-HTR2A (T102C), 5-HTTLPR, BDNF (Val66Met) polymorphisms previously reported to modify schizophrenia course are also associated with premorbid personality in schizophrenic patients.
After adjusting for age and APOE epsilon4 status, Val66Met polymorphism in BDNF was not associated with Alzheimer's disease in females (Meta-analysis).
Excessive daytime sleepiness is associated with higher serum BDNF and irisin levels.
Our results suggested that carriage of Met allele reduces the rate of long-term open-angle glaucoma (OAG) progression. However, the fact that this effect is observed only in females indicates BDNF Val66Met influences the progression rate of OAG in a sex-specific manner.
In BDNF, a novel non-synonymous variant and a rare frameshift variant, both affecting the centrally expressed longest preproBDNF transcript, were identified. Relevance for SNS is unlikely as persons with normal height also carry the mutation.
These findings of this study suggested that the BDNF Val66Met influences the development of amygdala-cortical circuits in a sex-specific and developmentally timed manner.
Study present evidence for a feed-forward loop whereby adrenergic signaling leads to increased tumoral innervation. In response to catecholamines, tumor cells produced BDNF in an ADRB3/cAMP/Epac/JNK-dependent manner. Elevated BDNF levels in the tumor microenvironment increased innervation by signaling through host neurotrophic receptor tyrosine kinase 2 receptors.
The genetic variant of BDNF rs6265G>A is shown to be associated with decreased risk of chronic postsurgical pain.
coexpression of BDNF and TrkB is associated with poor prognosis in small cell lung cancer patients
Studied plasma levels of brain derived neurotrophic factor (BDNF), nutritional status, and physical activity level in children with mild to severe CP.
Our findings show that disruption of BDNF from specific promoters leads to distinct body composition effects, with disruption from promoters I or II, but not IV or VI, inducing obesity.
Endogenous BDNF might be protective against apoptosis through GADD153 suppression and steatosis via SREBP-1c suppression during ER stress
The BDNF Met prodomain renders ventral CA1 - prelimbic projection neurons underdeveloped, preventing their capacity for subsequent circuit modulation necessary for fear extinction.
BDNF gene in mice fed high-fat diet was under-expressed by 0.30 fold with respect to chow-fed mice after 3 months of dietary intervention.
Results provide evidence of a causal relationship between reduced BDNF function in hippocampus and the anxiety susceptibility of aged mice.
Chronic unpredictable mild stress (CUMS) induced depressive-like behaviors and stimulated changes in brain regions expressing different BDNF levels. Depressive-like behaviors and region-specific BOLD activity in BDNF(tm1Krj/J) mice were consistent with those in wild-type CUMS-exposed mice. Findings suggested a potential central role of BDNF expression in functional changes in the brain.
Central BDNF, especially subfornical organ BDNF is involved in the maintenance of basal blood pressure and in augmentation of hypertensive response to angiotensin II.
The data of this study demonstrated that 24 h after fear conditioning, BDNF+/- mice exhibited an impaired fear memory expression.
This study demonstrated that Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.
Deficiency in MyD88 was associated with decreased BDNF expression. Furthermore, the authors identified a valid kappaB-binding site in the BDNF promoter, consistent with activation of NF-kappaB induced by inflammation.
The activation of PKCalpha during plasticity requires both NMDA receptor Ca(2+) flux and autocrine brain-derived neurotrophic factor (BDNF)-TrkB signaling, two pathways that differ vastly in their spatiotemporal scales of signaling
BDNF val66met polymorphism modulates the effects of developmental EtOH exposure on hippocampus and anxiety-like behavior.
Results show that BDNF haploinsufficiency substantially decreases the neuroprotective effect of the steroid mifepristone on Purkinje neurons. This suggests that a full expression of BDNF is critical to prevent the neurotoxicity induced by the GABAergic network activity.
Closer examination of genes implicated in the mechanisms of neuroplasticity, such as the NMDA and AMPA subunits and the BDNF pathway, reveal how wild-type mice upregulate many of these genes in response to stress, but Met allele carriers fail to do so.
This study found that BDNF deletion in the adult altered few itch or acute and chronic pain behaviors, beyond sexually dimorphic phenotypes in the tail immersion, histamine, and formalin tests.
CA3-specific deletion of BDNF results in deficits in circuits that process social cues from familiar conspecifics.
findings suggest that reductions in concentrations of BDNF results in altered status of excitability and excitation/inhibition imbalance.
It has been shown that the Wnt3a/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.
High BDNF expression is associated with anxiety and memory disorders in Huntington's disease.
These data suggested an anxiogenic- and antidepressant-like phenotype of ELA2 knockout, possibly associated with increased levels of BDNF in the prefrontal cortex.
Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]
BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.
One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination.
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC-derived alphaMSH, and that the light controls the biosynthesis and secretion of BDNF and of POMC end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.
measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
, brain derived neurothrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain-derived neurotrophic factor
, neurotrophic factor