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anti-Human BDNF Anticorps:
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Human Polyclonal BDNF Primary Antibody pour WB - ABIN3043096
Shi, Shao, Yuan, Pan, Li: Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. dans Yonsei medical journal 2010
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Mouse (Murine) Polyclonal BDNF Primary Antibody pour IHC (p), WB - ABIN3043798
Li, Xia, Zhang, Wu: S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk. dans PLoS ONE 2011
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Dog (Canine) Polyclonal BDNF Primary Antibody pour IHC, WB - ABIN2777093
Hashimoto, Moriguchi, Yamashita, Mori, Nemoto, Okada, Hori, Noguchi, Kunugi, Ohnishi: Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. dans Neuroscience research 2008
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Human Polyclonal BDNF Primary Antibody pour CyTOF, FACS - ABIN4899237
Xapelli, Bernardino, Ferreira, Grade, Silva, Salgado, Cavadas, Grouzmann, Poulsen, Jakobsen, Oliveira, Zimmer, Malva: Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. dans The European journal of neuroscience 2008
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Human Polyclonal BDNF Primary Antibody pour IHC, WB - ABIN6672757
Hang, Zhao, Sun, Li, Han, Du, Li: Brain-derived neurotrophic factor attenuates doxorubicin-induced cardiac dysfunction through activating Akt signalling in rats. dans Journal of cellular and molecular medicine 2017
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Human Polyclonal BDNF Primary Antibody pour DB, IHC (fro) - ABIN542616
Pezet, Malcangio, McMahon: BDNF: a neuromodulator in nociceptive pathways? dans Brain research. Brain research reviews 2003
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Mouse (Murine) Polyclonal BDNF Primary Antibody pour IHC, WB - ABIN3021893
Sidler, Aitken, Jiang, Sotiropoulos, Aggarwal, Anees, Chong, Siebenaller, Thanabalasingam, White, Choufani, Weksberg, Sangiorgi, Wrana, Delgado-Olguin, Bägli et al.: DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of ... dans The American journal of pathology 2018
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Human Polyclonal BDNF Primary Antibody pour WB - ABIN548503
Jones, Reichardt: Molecular cloning of a human gene that is a member of the nerve growth factor family. dans Proceedings of the National Academy of Sciences of the United States of America 1990
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Human Polyclonal BDNF Primary Antibody pour IHC, IHC (p) - ABIN4283816
Hasan Mahmood, Uddin, Ibrahim, Mandal, Alhamami, Briski et al.: Sex differences in forebrain estrogen receptor regulation of hypoglycemic patterns of counter-regulatory hormone secretion and ventromedial hypothalamic nucleus glucoregulatory neurotransmitter and ... dans Neuropeptides 2018
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Human Polyclonal BDNF Primary Antibody pour IF (p), IHC (p) - ABIN1387788
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. dans Neurobiology of disease 2014
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In systematic review, BDNF Val66Met polymorphism correlates with improved executive function while Val/Val homozygotes exhibited improved neurocognitive memory.
Study found that lower dietary quality, and surprisingly, higher BDNF levels, were associated with increased depression risk. A Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF.
Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
This is the first study showing the significant association between the BDNF rs6265 AA (Met/Met) genotype and overweight/obesity in Mexican pediatric population.
Results show that BDNF C270T polymorphisms may be associated with late onset Alzheimer's disease (LOAD) and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD.
Intracellular processing and efficacy was shown in HEK293 cells and SH-SY5Y neuroblastoma cells using plasmid DNA and after incorporating the TrkB-2A-mBDNF into an AAV2 vector. Increased BDNF/TrkB-mediated intracellular signaling pathways were observed after AAV2 vector transfection while increased TrkB phosphorylation could be detected in combination with neuroprotection from hydrogen peroxide-induced oxidative stress.
rs10767664 variant of BDNF gene modify anthropometric and biochemical changes after weight loss with a hypocaloric diet.
Epistasis between BDNF and HTR1A may contribute to the multifactorial risk for affective disorders.
This study demonstrated that Haploinsufficiency of the brain-derived neurotrophic factor gene is associated with reduced pain sensitivity.
The study revealed a lack of association of the BDNF rs6265 variant with obesity and obesity-related traits. On the other hand, the interaction between the BDNF rs6265 and overweight/obesity was found to be significantly associated with some of the obesity-related anomalous traits.
Results indicated that plasma BDNF level was associated with obesity, and also with BDNF Val66Met SNP. However, this association was not found between BDNF Val66Met SNP and obesity.
This article presents a review of BDNF as a neurobiological marker for schizophrenia and depression and for the efficacy of repetitive transcranial magnetic stimulation treatments of these mental diseases. [review]
BDNF Val66Met is Associated with Pre-existing but not with Paclitaxel-induced Peripheral Neuropathy in an Israeli Cohort of Breast Cancer Patients
there is clear evidence that severe impairment of fetal growth induces the increased production of fetal brain growth factor as an adaptive mechanism in reaction to a hostile intrauterine environment, thereby accelerating fetal brain development and maturation.
Low serum levels of BDNF at admission were significantly associated with poor short-term functional outcome and mortality in acute ischemic stroke patients.
The main finding of this study was that severely depressed inpatients who presented the most severe melancholic feature, psychomotor retardation, had significantly reduced BDNF levels in the blood.
Higher body mass index and smoking were associated with higher concentrations of serum BDNF in a working population from Japan.
In acute ischemic stroke patients, increased plasma cortisol was negatively associated with plasma BDNF and NO-2 levels.
Individuals with the BDNF val/val genotype are more likely to benefit from anodal-transcranial direct current stimulation during aphasia treatment.
Results found that BDNF was highly expressed in head and neck squamous cell carcinoma tissue and cell lines.
The data of this study demonstrated that 24 h after fear conditioning, BDNF+/- mice exhibited an impaired fear memory expression.
This study demonstrated that Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.
Deficiency in MyD88 was associated with decreased BDNF expression. Furthermore, the authors identified a valid kappaB-binding site in the BDNF promoter, consistent with activation of NF-kappaB induced by inflammation.
The activation of PKCalpha during plasticity requires both NMDA receptor Ca(2+) flux and autocrine brain-derived neurotrophic factor (BDNF)-TrkB signaling, two pathways that differ vastly in their spatiotemporal scales of signaling
BDNF val66met polymorphism modulates the effects of developmental EtOH exposure on hippocampus and anxiety-like behavior.
Results show that BDNF haploinsufficiency substantially decreases the neuroprotective effect of the steroid mifepristone on Purkinje neurons. This suggests that a full expression of BDNF is critical to prevent the neurotoxicity induced by the GABAergic network activity.
Closer examination of genes implicated in the mechanisms of neuroplasticity, such as the NMDA and AMPA subunits and the BDNF pathway, reveal how wild-type mice upregulate many of these genes in response to stress, but Met allele carriers fail to do so.
This study found that BDNF deletion in the adult altered few itch or acute and chronic pain behaviors, beyond sexually dimorphic phenotypes in the tail immersion, histamine, and formalin tests.
CA3-specific deletion of BDNF results in deficits in circuits that process social cues from familiar conspecifics.
findings suggest that reductions in concentrations of BDNF results in altered status of excitability and excitation/inhibition imbalance.
It has been shown that the Wnt3a/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.
High BDNF expression is associated with anxiety and memory disorders in Huntington's disease.
These data suggested an anxiogenic- and antidepressant-like phenotype of ELA2 knockout, possibly associated with increased levels of BDNF in the prefrontal cortex.
Prep1 deficiency alters olfactory morpho-functional integrity and olfaction-mediated eating behavior by affecting BDNF-TrkB signaling.
Electroconvulsive therapy in an animal model of depression increases BDNF expression in the cerebral cortex.
results provide evidence that adaptations in cortical (mPFC) BDNF activity resulting from chronic ethanol exposure play a role in mediating excessive ethanol drinking associated with dependence.
These results provide further evidence that Bdnf splice variants generate a spatial code that mediates the local actions of BDNF in distinct dendritic compartments on structural and functional plasticity.
Study demonstrated up-regulation of miR-210-3p by MPP+ reduces the brain-derived neurotrophic factor production and contributes to the dopaminergic neuron damage.
we found that the effect of genipin on PRS mice occurs through DNA demethylation by inhibiting DNA methyltransferase 1 (DNMT1), normalizing the expression of reduced brain-derived neurotrophic factor (BDNF) in the hippocampus
glucose administration increased phosphorylated Akt, phosphorylated CREB, exon 1- and exon 4-specific BDNF transcripts, and FGF1 transcripts that are associated with the epigenetic changes.
Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]
BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.
One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination.
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC-derived alphaMSH, and that the light controls the biosynthesis and secretion of BDNF and of POMC end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.
measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
, brain derived neurothrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain-derived neurotrophic factor
, neurotrophic factor