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EPHA7 is a positive upstream factor of C/EBPbeta contributing to the transcription and translation of KLF4, promoting ovulation via ADAMTS1. We demonstrated the functional role of EPHA7 in PCOS, which explains how the loss of EPHA7 underlies the ovulatory dysfunction.
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receptor phosphorylation of EphA7, at least in part, suppress prostate cancer tumor malignancy through targeting PI3K/Akt signaling pathways.
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these findings suggest that miR-448 functioned as a tumor suppressor gene in the development of osteosarcoma through targeting EPHA7.
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the interactions of EphA5/ephrinA5 and/or EphA7/ephrinA5 between HSPCs and BMSCs, independently and cooperatively, play a role in HSPC colony formation through the upregulation of GM-CSFR. Furthermore, the adhesion/migration of HSPCs appears to be mediated in part through the activation of Rac1.
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We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness.
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Eph receptor A7 may have an important role in the pathogenesis of nonsmall cell lung cancer by regulating PTEN expression via thephosphatase and tensin homolog/AKT pathway.
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Depletion of EphA7 remarkably inhibited the proliferation and invasion of Hep-2 and AMC-HN-8 cells in comparison to control and EphA7 siRNA negative control (NC)-transfected cells.
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Authors observed that the extracellular region of the EphA7 receptor was critical for interacting with caspase-8, whereas the cytoplasmic region of EphA7 was not.
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miR-137 is able to directly bind to the EPHA7 3'UTR and negatively regulate the expression of EPHA7 in HUVECs.
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MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma.
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The expression of EphA7 and/or MTDH might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma.
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Overexpression of EphA7 and/or MTDH might indicate poor prognosis in squamous cell cancer of the tongue.
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Data found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets.
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EPHA7 acts as a tumor suppressor in vivo and is targeted by genomic deletions and differential epigenetic silencing in human lymphomas.
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EphA7 protein expression is significantly correlated with the biological behavior of primary hepatocellular carcinoma.
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Data shew that the identification of three novel candidates as EPH receptor genes might indicate a link between perturbed compartmentalization of early neoplastic lesions and breast cancer risk and progression.
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analysis of the secreted form of EphA7 in lung cancer
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Eph-A5 and Eph-A7 staining intensity was identified as independent prognostic factors for pancreatic ductal adenocarcinoma
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downregulation of an Eph family gene in a solid tumor via aberrant 5'CpG island methylation, providing evidence that EphA7 gene is involved in human colorectal carcinogenesis
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EphA7 expression in 52 gastric carcinoma was consistent with its transcript expression, with the protein being significantly overexpressed in younger patients (P = .016) and in patients with advanced tumors (P = .033)
