Profil protéine

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Alternative names and synonyms associated with ERBB3

• erb-b2 receptor tyrosine kinase 3 (ERBB3) anticorps
• v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) anticorps
• erb-b2 receptor tyrosine kinase 3 (Erbb3) anticorps

• c-erbB-3 anticorps
• c-erbB3 anticorps
• C76256 anticorps
• Erbb-3 anticorps
• ERBB3 anticorps
• Afficher tous les alias de synonymes
• erbB3-S anticorps
• Erbb3r anticorps
• Her3 anticorps
• LCCS2 anticorps
• MDA-BF-1 anticorps
• nuc-ErbB3 anticorps
• p45-sErbB3 anticorps
• p85-sErbB3 anticorps
• p180-ErbB3 anticorps

Protein level used designations for ERBB3

proto-oncogene-like protein c-ErbB-3 , receptor tyrosine-protein kinase erbB-3 , tyrosine kinase-type cell surface receptor HER3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) , receptor tyrosine kinase ErbB3 , receptor tyrosine-protein kinase erbB-3-like , avian erythroblastosis oncogene B 3 receptor , c-erbB-3 , glial growth factor receptor , receptor tyrosine kinase , avian erythroblastosis oncogene B 3 , c-erbB3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 , v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3