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Our findings suggest that ErbB4 splicing may regulate the pruning of excitatory synapses on parvalbumin interneurons in the prefrontal cortex during adolescence.
the NRG-ErbB4 signaling pathway can potentially influence many functional systems throughout the brain of primates, and suggest that major sites of action are areas of the "corticolimbic" network
Widespread expression of ErbB4 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.
The role of ErbB4 in regulating motility was further controlled by targeted mutation of the endogenous erbb4a locus in the zebrafish genome by CRISPR/Cas9.
ErbBs regulate cell proliferation, movements, and embryonic patterning during early Xenopus development.
ErbB signaling control both convergent extension and head mesoderm migration during gastrulation.
Loss of Erbb4 expression is associated with impaired behavior and abnormal neural development.
the critical role of ErbB4 signaling in regulating locus coeruleus-noradrenergic neuronal function, is reported.
Study shows that within endoplasmic reticulum-related subsurface cistern, sigma-1 receptors, Kv2.1 and neuregulin-1 are clustered in highly specific, non-overlapping, microdomains, whereas ErbB2 and ErbB4 are present in the adjacent presynaptic compartment. This organization may define highly ordered and spatially restricted sites for different signal-transduction pathways.
Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1), which acts on luminal cells via Erbb3 and Erbb4 receptors.
Data suggest no direct involvement of a classical Nrg-ErbB4 pathway in attention and inhibitory control in mice, while it confirms the involvement of this pathway in other domains relevant to schizophrenia.
Erbb4-IR is a Smad3-dependent lncRNA that promotes renal fibrosis in type 2 diabetic nephropathy by suppressing miR-29b.
Deleting ErbB4 in parvalbumin-expressing neurons (PV neurons) significantly attenuated oligomeric Abeta-induced suppression of long term potentiation (LTP). Furthermore, specific ablation of ErbB4 in PV neurons via Cre/loxP system greatly improved spatial memory and synaptic plasticity in the hippocampus of human APP-J20 mice.
Study found that the ErbB4 signaling pathway in the prelimbic cortex was necessary to modulate fear expression.
Receptor protein-tyrosine kinase ErbB-4 (ERBB4) is expressed in the basal layer of human epidermis and cultured keratinocytes as well as in murine epidermis.
The manipulation of NRG1/ErbB4 signaling in the present study revealed that NRG1/ErbB4 activity in the hippocampus is critical for learning and memory.
This study demonstrated that deletion of the endothelial ErbB4 receptor is associated with reduced glucose transport ability and is a key element involved in energy metabolism for brain function.
we show that the antifibrotic effect of neuregulin-1 is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 activation in macrophages
These results suggest that the neuropsin-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin-expressing interneurons, and that neuropsin regulates E/I balance and gamma oscillations through NRG1-ErbB4 signaling toward parvalbumin-expressing interneurons.
findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 in regulating the initiation of critical period visual cortical plasticity.
To our knowledge, this is the first evidence that ErbB4 signaling in the MSNs is involved in the pathology of schizophrenia.
opposing signals generated by different ErbB dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.
Study revealed that bed nucleus of the stria terminalis NRG1-ErbB4 signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
Parallel microarray profiling identifies Erbb4 as a marker of cyst growth in autosomal dominant polycystic kidney disease and as a prognostic marker for disease progression.
a suppressor of miR-146a, suggesting an autocrine loop. Inhibition of ErbB4/EGFR with erlotinib co-treatment of podocytes suppressed this signaling. Findings suggest a novel role for miR-146a in protecting against diabetic glomerulopathy and podocyte injury.
the disruption of NRG1-ErbB4 signaling in the parvalbumin interneurons mediated by neuroinflammation might lead to abnormal gamma oscillations and thus contribute to cognitive impairment in a mouse model of SAE
Study found a significantly improved survival in tamoxifen-treated postmenopausal breast cancer patients in the absence of HER4 compared with those with pronounced HER4 expression and suggest an HER4/estrogen receptor interaction that impedes tamoxifen binding to the estrogen receptor and reduces treatment efficiency.
ERBB4 rs186724 GG polymorphism in miR-335 binding site is associated with poor prognosis in Chinese ovarian cancer patients.
rs13423759 allele C is capable to strengthen the interaction between miR-548as, an oncomiRNA, and ErbB4 mRNA, leading to its lowered concentration in the cells. CONCLUSION: rs13423759 allele C is significantly associated with the enhanced risk of breast cancer, elevated metastasis and HER2 positivity.
ERBB4 rs839523 is significantly associated with tardive dyskinesia occurrence in schizophrenia patients.
The two most common deletions were tumor-suppressor genes RB1 and ERBB4 in chromophobe renal cell carcinoma but not renal oncocytoma.
A novel SNP, rs4672619, shows interactive effects with depression on asthma symptom severity in two cohorts of childhood and elderly asthmatics.
ErbB4 splicing and parvalbumin interneuron expression influence the severity of schizophrenia and mood disorders.
Our present results suggest that NRG1/ErbB4 signalling could be an important event in the pathogenesis of progressive supranuclear palsy.
There was no significant correlation between a positive expression of CD44 and the prognosis of patients (P>0.05). The expressions of HER4 and CD44 were not significantly correlated with sex, age, pigment, tumor site, etc. (P>0.05). Results further emphasize a correlation between HER4 and CD44 expressions in SNMMM tissues.
Study finds that optimal processing of aversive prediction errors is reduced in individuals genetically predisposed (polymorphisms in GABRB2 and ErbB4) towards decreased GABA neurotransmission.
Studied association of two erb-b2 receptor tyrosine kinase 4 (ERBB4) polymorphisms with genetic predisposition of schizophrenia in a Jordanian Arab population.
ERBB4 rs1351592 confers risk for polycystic ovary syndrome in Han Chinese.
Results found that ERBB4 was highly expressed in gastric cancer cell (GC) lines and tumors and closely related to the poor prognosis of GC patients. Other data indicated that ERBB4 promoted cell proliferation via PI3K/Akt signaling pathway.
Study found that the protein levels of NRG1 and ErbB4 were significantly increased in the temporal cortex of patients with symptomatic epilepsy. Also, NRG1-ErbB4 signaling suppresses GluN2B phosphorylation by Src inhibition. GluN2B is closely related to synaptic activity and its regulation by the NRG1-ErbB4-Src signaling axis highlights the importance of NRG1-ErbB4 signaling in symptomatic epilepsy pathology.
Results demonstrate that 4-PBA promotes gastric cancer cells migration through upregulation of HER3/HER4 subsequent to increased levels of acetyl-histone and activation of ERK signaling.
present study shows that HER4 and/or NDRG1 might play a critical role for the cell survival and chemo-resistance of Osteosarcoma (OS), and could be used as potential therapeutic targets in OS.
This study support the involvement of Neuregulin signaling pathway in smoking behavior but not in alcohol use and abuse, and disclose functional potential for 56 of the 66 associated single-nucleotide polymorphism and underlining the involvement of ERBB4 in SI, ND and NW.
These finding suggests that miR-302b inhibits key transcription factors and cytokines by targeting ERBB4, IRF2 and CXCR4, implicating its role in the inhibition of CRI in EC.
we have exploited the hidden information inside ErbB4 kinase receptor both at sequence and structural level. PSI-BLAST algorithm is used to search similar sequences against ErbB4 kinase sequence. Top 15 sequences with high identity were selected for finding conserved and variable regions among sequences using multiple sequence alignment
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
, receptor tyrosine-protein kinase erbB-4
, v-erb-a erythroblastic leukemia viral oncogene homolog 4
, receptor tyrosine-protein kinase erbB-4-like
, receptor tyrosine kinase ErbB4
, receptor tyrosine-protein kinase ErbB-4
, ovarian receptor tyrosine kinase erbB4 precusor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 4
, proto-oncogene-like protein c-ErbB-4
, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
, tyrosine kinase-type cell surface receptor HER4