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anti-Mouse (Murine) FGF19 Anticorps:
anti-Rat (Rattus) FGF19 Anticorps:
anti-Human FGF19 Anticorps:
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Human Monoclonal FGF19 Primary Antibody pour ELISA, WB - ABIN523342
Shang, Guo, Honda, Saumoy, Salen, Xu: FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. dans Journal of lipid research 2013
These data identify hypothalamic Fgf15 as a regulator of glucagon (Montrer GCG Anticorps) secretion.
Fgf15 is the sonic hedgehog (Montrer SHH Anticorps) downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (Montrer NR1H4 Anticorps) target genes Fgf15 and Shp (Montrer LAMC1 Anticorps) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (Montrer NR1H4 Anticorps) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
This study demonstrates that the FGF19-SHP (Montrer LAMC1 Anticorps)-LSD1 (Montrer KDM1A Anticorps) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.
This study reveals SHP (Montrer LAMC1 Anticorps) as a global transcriptional partner of SREBP-2 (Montrer SREBF2 Anticorps) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19.
Protective effects of farnesoid X receptor (Montrer xpr1 Anticorps) on hepatic lipid accumulation are mediated by hepatic FXR (Montrer NR1H4 Anticorps) and are independent of intestinal FGF15 signaling.
Intestinal PPARalpha (Montrer PPARA Anticorps)-UDP- Glucuronyltransferases and downstream FXR (Montrer NR1H4 Anticorps)-FGF15 signalling play vital roles in control of bile acid homeostasis and the pathological development of colitis.
a direct role of intestinal FGF15/19 in the regulation of SI P450 (Montrer POR Anticorps) expression and may have profound implications for the prediction of drug exposure in patients with compromised hepatic P450 (Montrer POR Anticorps) function
findings implicate the brain in the antidiabetic action of systemic FGF19 and establish the brain's capacity to rapidly, potently, and selectively increase insulin (Montrer INS Anticorps)-independent glucose disposal
FGFR4 (Montrer FGFR4 Anticorps)/FGF19 autocrine signaling mediates the survival of a subset of basal-like breast cancer cells
FGF19 copy number may increase in hepatocellular carcinoma accompanying a complete response to sorafenib treatment
Study demonstrates that elevated FGF19 expression or hyperactivation of FGF19/FGFR4 (Montrer FGFR4 Anticorps) signaling in hepatocellular carcinoma cells is one of the main mechanisms of sorafenib resistance.
This is the first study to elucidate FGF19/FGFR4 (Montrer FGFR4 Anticorps) signaling in favor of hepatocellular carcinoma cells developing from fatty liver
High expression of FGF19 is associated with hepatocellular carcinoma.
Findings show that FGF19 provides a cytoprotective role against ER stress by activating a FGFR4 (Montrer FGFR4 Anticorps)-GSK3beta-Nrf2 (Montrer GABPA Anticorps) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) management.
Fibroblast growth factor 19 levels in human portal blood are higher than in arterial blood. Fibroblast growth factor 19 is released by the portal-drained viscera under fasted steady state conditions.
serum FGF19 and FGF21 (Montrer FGF21 Anticorps) and hepatic Klotho (Montrer KL Anticorps) expression are inversely associated with hepatic damage in children with NAFLD (Montrer TSC2 Anticorps)
Administering FGF19, or suitable mimetic, as a pharmacological intervention to increase circulating levels of FGF19 and suppress BA synthesis by inhibiting CYP7A1 (Montrer CYP7A1 Anticorps) gene expression is likely to provide therapeutic benefits for many PBC (Montrer DLAT Anticorps) patients
Amplification of FGF19 was validated in independent LSCC samples. Furthermore, FGF19 stimulated LSCC cell growth in vitro. These data implicate FGF19 as a potential driver gene in LSCC with clinic characteristics as smoking.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
fibroblast growth factor 19
, fibroblast growth factor 15