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anti-Mouse (Murine) GRB2 Anticorps:
anti-Rat (Rattus) GRB2 Anticorps:
anti-Human GRB2 Anticorps:
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Human Polyclonal GRB2 Primary Antibody pour ELISA, IHC - ABIN257708
Lowenstein, Daly, Batzer, Li, Margolis, Lammers, Ullrich, Skolnik, Bar-Sagi, Schlessinger: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. dans Cell 1992
Human Polyclonal GRB2 Primary Antibody pour IHC (p), WB - ABIN390236
Kondo, Hirayama, Sugito, Shono, Tanaka, Kitamura: Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. dans The Journal of biological chemistry 2008
Show all 3 Pubmed References
Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell .
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 (Montrer VAV1 Anticorps) activity and Grb2 stability
Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP.
Two Dtna (Montrer DTNA Anticorps) interactors, alpha-catulin (Montrer CTNNAL1 Anticorps) (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.
Grb2-deficient T cells show defects in T cell development, increased Th1 (Montrer HAND1 Anticorps) and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.
provide evidence that CD28 (Montrer CD28 Anticorps) and the TCR complex regulate NF-kappaB (Montrer NFKB1 Anticorps) via different signaling modules of GRB-2/VAV1 (Montrer VAV1 Anticorps) and LAT (Montrer LAT Anticorps)/ADAP (Montrer APP Anticorps) pathways respectively.
GRB2 physically links cyt (Montrer CYGB Anticorps)-PTPe (Montrer PTPRE Anticorps) with Src (Montrer SRC Anticorps) and enables cyt (Montrer CYGB Anticorps)-PTPe (Montrer PTPRE Anticorps) to activate Src (Montrer SRC Anticorps) downstream of activated integrins in osteoclast-like cells.
SUMOylation of Grb2 enhances the ERK (Montrer EPHB2 Anticorps) activity by increasing its binding with Sos1 (Montrer SOS1 Anticorps).
Data indicate that growth factor receptor (Montrer RYK Anticorps) protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3 (Montrer FOXD3 Anticorps)), and pregulated Grb2 interacts with huntingtin (Htt (Montrer HTT Anticorps)).
Grb2 contributes to immunoreceptor tyrosine-based activation motif signaling in platelets during hemostasis and thrombosis.
The binding site of miR (Montrer MLXIP Anticorps)-433-3p was identified in the 3'UTR (Montrer UTS2R Anticorps) region of GRB2. Western blotting and FQ-PCR showed that miR (Montrer MLXIP Anticorps)-433-3p inhibited the mRNA and protein expression of GRB2.
study unravels a unique role of Grb2 in protecting the cytoskeletal architecture in AD-like conditions and presents a potential new strategy for controlling neurodegeneration
M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by gamma Fc receptors, Grb2, and SHP-1.
Data indicate GRB2 as a direct target of miR (Montrer MLXIP Anticorps)-329 in pancreatic cancer cells, and expression of GRB2 was inversely correlated with miR (Montrer MLXIP Anticorps)-329 expression in pancreatic cancer patients.
EGFR (Montrer EGFR Anticorps) colocalization with GRB2 as assessed by PLA is not correlated with EGFR (Montrer EGFR Anticorps) expression levels or mutation status, defining a patient group that may show EGFR (Montrer EGFR Anticorps) pathway activation, as illustrated by its prognostic value.
Low GRB2 expression is associated with Breast Cancer.
Rab13 (Montrer RAB13 Anticorps) activated the downstream AMPK (Montrer PRKAA1 Anticorps) and blocked mTOR (Montrer FRAP1 Anticorps) signaling by its functional interaction with Grb2 to regulate autophagy in human vascular endothelial cells.
ACTB (Montrer ACTB Anticorps), CDKN1B (Montrer CDKN1B Anticorps), GAPDH (Montrer GAPDH Anticorps), GRB2, RHOA (Montrer RHOA Anticorps) and SDCBP (Montrer SDCBP Anticorps) are potent reference genes in neuroendocrine tumors of the lung.
We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (Montrer AKT1 Anticorps). As well as defining a novel mechanism of Akt (Montrer AKT1 Anticorps) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (Montrer FGFR2 Anticorps), Plc11 and Grb2 correlate with patient survival
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Montrer SHC1 Anticorps) (Gads (Montrer GRAP2 Anticorps)), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (Montrer SRC Anticorps) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (Montrer CD28 Anticorps) with variable affinity
in VSMCs exposed to hyperglycemia, IGF-I (Montrer IGF1 Anticorps) stimulation of Shc (Montrer SHC1 Anticorps) facilitates the transfer of Grb2 to p85 (Montrer ARHGEF7 Anticorps) resulting in enhanced PI3K activation and AKT (Montrer AKT1 Anticorps) phosphorylation leading to enhanced cell proliferation and migration
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth factor receptor-bound protein 2
, Growth factor receptor-bound protein 2
, SH2/SH3 adapter GRB2
, adapter protein GRB2
, protein Ash
, abundant SRC homology
, epidermal growth factor receptor-binding protein GRB2
, growth factor receptor-bound protein 3
, growth factor receptor bound protein 2