Profil protéine

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with HGF

• hepatocyte growth factor (HGF) anticorps
• hepatocyte growth factor (Hgf) anticorps

• C230052L06Rik anticorps
• DFNB39 anticorps
• F-TCF anticorps
• HGF anticorps
• HGF/SF anticorps
• Afficher tous les alias de synonymes
• HGFB anticorps
• HPTA anticorps
• NK1 anticorps
• NK2 anticorps
• SF anticorps
• SF/HGF anticorps

Protein level used designations for HGF

fibroblast-derived tumor cytotoxic factor , hepatocyte growth factor , hepatopoeitin-A , hepatopoietin-A , lung fibroblast-derived mitogen , SF , scatter factor , hepapoietin A , HGF alpha-chain , hepatocyte growth factor /scatter factor