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anti-Human IGF1 Anticorps:
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Human Polyclonal IGF1 Primary Antibody pour IHC (p), WB - ABIN3044390
Li, Zhang, Li, Zhao, Zhai, Yang, Kong, Wu, Chen, Teng: miR-18a counteracts AKT and ERK activation to inhibit the proliferation of pancreatic progenitor cells. dans Scientific reports 2017
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Human Polyclonal IGF1 Primary Antibody pour IF (p), IHC (p) - ABIN723605
Baykara, Aksu, Buyuk, Kiray, Sisman, Baykara, Dayi, Tas, Ozdemir, Arda, Uysal et al.: Progesterone treatment decreases traumatic brain injury induced anxiety and is correlated with increased serum IGF-1 levels; prefrontal cortex, amygdala, hippocampus neuron density; and reduced serum ... dans Biotechnic & histochemistry : official publication of the Biological Stain Commission 2013
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Human Polyclonal IGF1 Primary Antibody pour IHC (p), WB - ABIN966342
Jansen, van Schaik, Ricker, Bullock, Woods, Gabbay, Nussbaum, Sussenbach, Van den Brande: Sequence of cDNA encoding human insulin-like growth factor I precursor. dans Nature 1984
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Mouse (Murine) Polyclonal IGF1 Primary Antibody pour WB - ABIN4321494
Go, Srivastava, Hernandez-Ono, Gang, Smith, Booth, Ginsberg, Mani: The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. dans Cell metabolism 2014
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Human Polyclonal IGF1 Primary Antibody pour ELISA, IHC - ABIN1586056
Malempati, Weigel, Ingle, Ahern, Carroll, Roberts, Reid, Schmechel, Voss, Cho, Chen, Krailo, Adamson, Blaney: Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. dans Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012
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Human Polyclonal IGF1 Primary Antibody pour Neut, ELISA - ABIN223533
Lewy, Ryan, Read, Fong, Poole, Seed, Sharma, Smith, Kwan, Stewart, Bacon, Warfield, Franklyn, McCabe, Boelaert: Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells. dans Endocrinology 2013
Human Polyclonal IGF1 Primary Antibody pour ELISA, Func - ABIN2474318
Singer, Mogg, Koestler, Pacher, Marton, Kubista, Schreiber: Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Human Polyclonal IGF1 Primary Antibody pour ICC, IF - ABIN4321496
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. dans Molecular pharmaceutics 2015
Human Polyclonal IGF1 Primary Antibody pour ELISA, WB - ABIN4321495
Furundzija, Fritzsche, Kaufmann, Meyborg, Fleck, Kappert, Stawowy: IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling. dans Biochemical and biophysical research communications 2010
Bio informatics analysis of 982 lung cancer patients revealed that higher expression of TNF- alpha (Montrer TNF Anticorps) was associated with low risk of cancer progression while overexpression of IGF-1 was correlated with high risk. Collectively, these results reveal that the cytokines in the tumor microenvironment differentially modulate radiation therapy through a variety of signaling mechanisms.
Data suggest that lower IGF1 serum levels in aging are associated with lower handgrip strength and worse physical performance, but less recurrent falls, especially in men. This longitudinal study was conducted in the Netherlands.
Data suggest that R1353H point mutation constitutes an activating IGF1R variant that can result in extreme tall height with very low levels of serum IGFI; the mutation was observed in proband, his mother, and his 3 sons, however, only the proband (43 y/o) and eldest son (18 y/o) exhibit extreme tall height. [CASE REPORT]
IGF-1 treatment activated protein kinase B (AKT (Montrer AKT1 Anticorps)), which may inhibit autophagy via the AKT (Montrer AKT1 Anticorps)/mammalian target of rapamycin (Montrer FRAP1 Anticorps) signaling pathway. Following inhibition of autophagy, drug resistant cells became sensitive to apoptosis induced by 5-fluorouracil.
Consistent with its enhanced expression in Laron syndrome, we provide evidence that TXNIP (Montrer TXNIP Anticorps) gene expression is negatively regulated by IGF1.
In elderly women with low-energy distal radius fractures, an association between IGF1 and lowest measures of bone mineral density was found, indicating that low IGF1 could be an indirect risk factor for fractures.
Expression of miR (Montrer MLXIP Anticorps)-30a-3p was significantly increased in the placentas of patients with preeclampsia. miR (Montrer MLXIP Anticorps)-30a-3p might be involved in the pathogenesis of preeclampsia by targeting IGF-1 and regulating the invasion and apoptosis of trophoblast cells.
results suggest that the different isoforms of the PI3K (Montrer PIK3CA Anticorps) p110 subunit could be therapeutic targets for primary and metastatic colon cancer and that regulation of the NRD1 (Montrer NRD1 Anticorps)/ADAM signaling pathway controls lipogenesis-mediated EMT (Montrer ITK Anticorps) in IGF-1-stimulated colon cancer cells.
Demonstrate the uptake of fluorescently labeled IGF-I into skeletal growth plates of live mice using multiphoton microscopy.
Study provides evidence that IGF-1/IGF-1R (Montrer IGF1R Anticorps)/hsa (Montrer CD24 Anticorps)-let-7c axis can control the odonto/osteogenic differentiation of IGF-1-treated stem cells from apical papilla via the regulation of JNK (Montrer MAPK8 Anticorps) and p38 MAPK (Montrer MAPK14 Anticorps) signaling pathways.
Combined treatment with electrical stimulation and insulin-like growth factor-1 promotes bone regeneration in vitro.
Enteric neural stem cells expressing IGF1 has been proposed as a novel cellular therapy for Hirschsprung's Disease tested in a mouse model.
Deficiency in the liver-derived IGF-I does not affect wound healing in mice, neither in normoglycemic conditions nor in diabetes.
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin (Montrer INS Anticorps)/InsR (Montrer INSR Anticorps) and IGF-1/IGF-1R (Montrer IGF1R Anticorps) signaling. Insulin (Montrer INS Anticorps) therapy in the early stage may delay diabetic gastroparesis
these results indicate that IGF-I induces senescence of hepatic stellate cells, inactivates these cells and limits fibrosis in a p53 (Montrer TP53 Anticorps)-dependent manner and that IGF-I may be applied to treat nonalcoholic steatohepatitis and cirrhosis.
IGF-1 is involved in hepatic mitochondrial protection, because it is able to reduce free radical production, oxidative damage and apoptosis. All these IGF-1 actions are mediated by the modulation of the expression of genes encoding citoprotective and antiapoptotic proteins.
Inhibition of mammalian target of rapamycin (mTOR (Montrer FRAP1 Anticorps)) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression
Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1 (Montrer CCL2 Anticorps), CCL5/RANTES (Montrer CCL5 Anticorps) and IGF-1 in vitro.
These data indicate that KSR2 (Montrer CNKSR2 Anticorps) functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 expression in the liver of neonatal mice, which plays a key role in the development of body length.
The data demonstrate that miR (Montrer MLXIP Anticorps)-206 sensitizes nasopharyngeal carcinoma cells to irradiation by targeting IGF1, highlighting the therapeutic potential of miR (Montrer MLXIP Anticorps)-206 in nasopharyngeal carcinoma radiosensitization.
the dipeptide Pro-Asp (Montrer ASIP Anticorps) promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (Montrer FRAP1 Anticorps) and PPARg (Montrer PPARG Anticorps). In summary, PPARg (Montrer PPARG Anticorps) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (Montrer HGF Anticorps) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (Montrer CEBPA Anticorps) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (Montrer LEP Anticorps) on cell proliferation/apoptosis, MAP kinase (Montrer MAPK1 Anticorps) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (Montrer LEP Anticorps). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (Montrer SLC23A2 Anticorps) is expressed in IVD (Montrer IVD Anticorps) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (Montrer INS Anticorps) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (Montrer GH1 Anticorps)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (Montrer INS Anticorps)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (Montrer TNF Anticorps).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Results suggest that locally derived intra-ovarian IGF1 may have a role in the differentiation and growth of primary follicles in zebrafish ovary.
Study demonstrated that IGF-I can stimulate egfr (Montrer EGFR Anticorps) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (Montrer EGF Anticorps), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (Montrer PGC Anticorps) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (Montrer IGFBPI Anticorps)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (Montrer AKT1 Anticorps) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (Montrer BMP4 Anticorps), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (Montrer XBP1 Anticorps) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (Montrer AKT1 Anticorps) pathway in unfolded protein
IGF1/RsaI was associated with average daily weight gain in cattle.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (Montrer STAT5A Anticorps) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (Montrer POU1F1 Anticorps) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (Montrer LHCGR Anticorps) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (Montrer INS Anticorps)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (Montrer MAPK1 Anticorps)-mediated signaling pathways.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (Montrer IGFBP3 Anticorps)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (Montrer INSR Anticorps) and/or insulin-like growth factor-1 receptor (Montrer IGF1R Anticorps) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (Montrer IGF1R Anticorps) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (Montrer HSP90AB1 Anticorps) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN (Montrer MSTN Anticorps) mRNA may participate in ordering duck muscle growth rates with selected development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A