anti-Rat (Rattus) IGF1R anticorps pour Immunofluorescence

Recommended IGF1R Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Insulin-Like Growth Factor 1 Receptor (IGF1R) Anticorps
  • CD221
  • IGFIR
  • IGFR
  • JTK13
  • IGFIRC
  • IGFR1
  • IGF-1R
  • IGF1R
  • DKFZp469I0618
  • igf-1r
  • xIGF-1R
  • xIGFR
  • xigf1r
  • A330103N21Rik
  • D930020L01
  • hyft
  • igf-ir
  • IGF-IRa
  • sb:eu1090
  • wu:fi20b10
  • insulin like growth factor 1 receptor
  • insulin-like growth factor 1 receptor
  • insulin-like growth factor I receptor
  • insulin like growth factor 1 receptor S homeolog
  • insulin-like growth factor 1a receptor
  • IGF1R
  • Igf1r
  • igf1r
  • LOC780503
  • LOC100136427
  • igf1r.S
  • igf1ra
Épitope
pTyr1346
52
46
42
41
29
28
27
23
18
16
16
15
15
15
13
13
10
9
8
7
7
7
6
6
6
5
5
4
4
4
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
588
337
314
26
20
18
17
16
13
11
6
3
2
1
1
Hôte
Lapin
460
128
2
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp IGF1R est non-conjugé
21
19
18
18
12
12
8
8
8
8
8
8
8
8
8
8
6
3
3
3
3
2
2
2
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
409
191
160
110
104
93
88
52
39
15
8
6
5
3
2
2
2
2
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Images

N° du produit ABIN6256637
$ 390.77
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
17.5 ABIN6255780 ELISA ICC IF IHC WB Rabbit IgG pTyr1165, pTyr1166 Connectez-vous pour afficher Polyclonal 1
16 ABIN6256620 ELISA ICC IF IHC IP WB Rabbit IgG pTyr1161 Connectez-vous pour afficher Polyclonal 0
14.801548 ABIN3182743 ELISA IF IHC WB Rabbit IgG pTyr1161 Connectez-vous pour afficher Polyclonal 0
14.646198 ABIN2704917 IC IF IP IHC WB Rabbit C-Term, pTyr1161 Connectez-vous pour afficher Polyclonal 0
14.646198 ABIN1870257 IF IHC WB Rabbit IgG pTyr1161 Connectez-vous pour afficher Polyclonal 0
14.5 ABIN2792087 IF IHC WB Rabbit Middle Region Connectez-vous pour afficher Polyclonal 2
13 ABIN6262491 ELISA ICC IF IHC WB Rabbit IgG Connectez-vous pour afficher Polyclonal 0
11.646198 ABIN1870256 IF WB Rabbit IgG pTyr1165, pTyr1166 Connectez-vous pour afficher Polyclonal 0
11.646198 ABIN6579915 IF WB Rabbit IgG pTyr1165, pTyr1166 Connectez-vous pour afficher Polyclonal 0
10 ABIN6262490 ELISA ICC IF IHC WB Rabbit IgG Connectez-vous pour afficher Polyclonal 0
10 ABIN6262489 ELISA ICC IF WB Rabbit IgG Connectez-vous pour afficher Polyclonal 0
10 ABIN6652543 IF IHC (p) WB Rabbit Tyr1161 Connectez-vous pour afficher Polyclonal 0
8.319532 ABIN4321576 ICC IF WB Rabbit AA 700-800, Internal Region Connectez-vous pour afficher Polyclonal 1
7 ABIN6254914 ELISA ICC IF WB Rabbit IgG N-Term Connectez-vous pour afficher Polyclonal 0
7 ABIN6579914 IF IHC WB Rabbit IgG pTyr1161 Connectez-vous pour afficher Polyclonal 0
7 ABIN6580265 IF IHC WB Rabbit IgG Connectez-vous pour afficher Polyclonal 0
5.5 ABIN362636 IF IHC WB Rabbit IgG AA 1159-1163 Connectez-vous pour afficher Polyclonal 2
5.5 ABIN362040 IF WB Rabbit IgG pTyr1166 Connectez-vous pour afficher Polyclonal 2
4 ABIN5961127 ELISA IF IHC (p) WB Rabbit IgG pTyr1161 Connectez-vous pour afficher Polyclonal 0
4 ABIN5961123 ELISA IF IHC (p) WB Rabbit IgG Tyr1161 Connectez-vous pour afficher Polyclonal 0

General

Antigène Insulin-Like Growth Factor 1 Receptor (IGF1R) Anticorps
Épitope pTyr1346
(52), (46), (42), (41), (29), (28), (27), (23), (18), (16), (16), (15), (15), (15), (13), (13), (10), (9), (8), (7), (7), (7), (6), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(588), (337), (314), (26), (20), (18), (17), (16), (13), (11), (6), (3), (2), (1), (1)
Hôte Lapin
(460), (128), (2), (2), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp IGF1R est non-conjugé
(21), (19), (18), (18), (12), (12), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (6), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(409), (191), (160), (110), (104), (93), (88), (52), (39), (15), (8), (6), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Fournisseur Connectez-vous pour afficher

Détail du produit anti-IGF1R anticorps

Détail du antigène IGF1R Information d'application Stockage Images
Specificité Phospho-IGF1R (Tyr1346) Antibody detects endogenous levels of IGF1R only when phosphorylated at Tyrosine 1346
 Réactivité croisée Humain, Souris, Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogène A synthesized peptide derived from human IGF1R around the phosphorylation site of Tyrosine 1346
Isotype IgG
Plasmids, Primers & others

Détail du antigène IGF1R

Détail du produit anti-IGF1R anticorps Information d'application Stockage Images Haut de la page
Antigène
Autre désignation IGF1R (IGF1R Antibody Extrait)
Sujet

Description: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.

Gene: IGF1R

Poids moléculaire kDa
ID gène 3480
UniProt P08069
Pathways Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy

Information d'application

Détail du produit anti-IGF1R anticorps Détail du antigène IGF1R Stockage Images Haut de la page
Indications d'application IHC 1:50-1:200 WB 1:500-1:2000, IF/ICC 1:100-1:500
Restrictions For Research Use only

Stockage

Détail du produit anti-IGF1R anticorps Détail du antigène IGF1R Information d'application Images Haut de la page
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20 °C.Stable for 12 months from date of receipt
Date de péremption 12 months

Images

Détail du produit anti-IGF1R anticorps Détail du antigène IGF1R Information d'application Stockage Haut de la page
Images (Fournisseur)
Western Blotting (WB) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) Western blot analysis of Phospho-IGF1R (Tyr1346) expression in various lysates
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) ABIN6267336 staining 293 by IF/ICC. The sample were fixed with PFA and permeabilized ...
Immunohistochemistry (IHC) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) ABIN6267336 at 1/200 staining Human heart tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) ABIN6267336 at 1/200 staining Human heart tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) ABIN6267336 at 1/200 staining Human lung cancer tissue sections by IHC-P. The tissue ...
Immunohistochemistry (IHC) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) ABIN6267336 at 1/200 staining Rat lung tissue sections by IHC-P. The tissue was forma...
Immunohistochemistry (IHC) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) ABIN6267336 at 1/200 staining Rat lung tissue sections by IHC-P. The tissue was forma...
Immunohistochemistry (IHC) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody (ABIN6256637) ABIN6267336 at 1/200 staining Rat ganstric tissue sections by IHC-P. The tissue was f...