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Human Polyclonal INSRR Primary Antibody pour IHC (p), ELISA - ABIN544315
Hänze, Berthold, Klammt, Gallaher, Siebler, Kratzsch, Elmlinger, Kiess: Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. dans Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999
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Human Polyclonal INSRR Primary Antibody pour IHC (p), ELISA - ABIN544316
Shier, Watt: Primary structure of a putative receptor for a ligand of the insulin family. dans The Journal of biological chemistry 1989
Show all 3 Pubmed References
the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain.
IRR activation involves two separate centers of pH-dependent rearrangements that act synergistically to induce a major conformational change in the IRR molecule, resulting in internal kinase domains rapprochement and autophosphorylation.
IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points.
Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. (Review)
Analysis of structural determinants of alkali sensor IRR positive cooperativity.
IRR mRNA expression was found in 25 (51%) neuroblastomas and correlated with stages 1, 2, 3, and 4S disease and with age.
Phosphotyrosine detection revealed a lack in the constitutive activation of the IRR described for analogous constructs of the two other members of the family
The IRR gene is expressed in the same ovarian compartment, IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus.
The obtained data suggest that the IRR gene inactivation results in disturbances of the aggressive-defensive behavior typical of the parental mouse strain c57bl.
The activation of IRR by alkali might be part of a local loop of signaling between the exocrine and endocrine parts of the pancreas where alkalinization of the juice facilitate insulin release that increases the volume of secreted juice to control its pH and bicabonate content.
Disruption of insulin receptor-related receptor in mice impairs the renal response to alkali loading attested by development of metabolic alkalosis and decreased urinary bicarbonate excretion in response to this challenge
the insulin receptor tyrosine kinase family, comprising Ir, Igf1r and Irr, is required for the appearance of male gonads and thus for male sexual differentiation
Insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) were targeted and compared as central distributors of the insulin signal, the insulin receptor, the insulin-like growth factor 1 receptor, and the insulin receptor-related receptor.
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
, insulin receptor-related protein
, insulin receptor-related receptor
, insulin receptor-related protein-like