Aperçu des produits pour anti-INSRR (INSRR) Anticorps

Full name:: anti-Insulin Receptor-Related Receptor Anticorps (INSRR)

Chez www.anticorps-enligne.fr sont 98 Insulin Receptor-Related Receptor (INSRR) Anticorps de 20 de différents fournisseurs disponibles. De plus, nous expédions INSRR Protéines (21) et INSRR Kits (3) et beaucoup plus de produits pour cette protéine. Un total de 125 INSRR produits sont actuellement listés.

Synonymes:: INSRR, Irr, MGC68585, Sirr

afficher tous les anticorps	Gène	GeneID	UniProt
	INSRR	3645	P14616
	INSRR	23920	Q9WTL4
	INSRR	60663	Q64716
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Réactivités les plus populaires pour anti-INSRR (INSRR) Anticorps

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anti-Human INSRR Anticorps:

anti-Mouse (Murine) INSRR Anticorps:

anti-Rat (Rattus) INSRR Anticorps:

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Pathways pertinentes pour anti-INSRR Anticorps

Signalisation RTK

Plus produit pour INSRR Anticorps

anti-INSRR Anticorps mieux référencés

Human Polyclonal INSRR Primary Antibody pour IHC (p), ELISA - ABIN544315 : Hänze, Berthold, Klammt, Gallaher, Siebler, Kratzsch, Elmlinger, Kiess: Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. dans Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999 (PubMed)
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Human Polyclonal INSRR Primary Antibody pour IHC (p), ELISA - ABIN544316 : Shier, Watt: Primary structure of a putative receptor for a ligand of the insulin family. dans The Journal of biological chemistry 1989 (PubMed)
Show all 3 Pubmed References

Plus d’anticorps contre INSRR partenaires d’interaction

Human Insulin Receptor-Related Receptor (INSRR) interaction partners

the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain.
IRR activation involves two separate centers of pH-dependent rearrangements that act synergistically to induce a major conformational change in the IRR molecule, resulting in internal kinase domains rapprochement and autophosphorylation.
IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points.
Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. (Review)
Analysis of structural determinants of alkali sensor IRR positive cooperativity.
IRR mRNA expression was found in 25 (51%) neuroblastomas and correlated with stages 1, 2, 3, and 4S disease and with age.
Phosphotyrosine detection revealed a lack in the constitutive activation of the IRR described for analogous constructs of the two other members of the family
The IRR gene is expressed in the same ovarian compartment, IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus.

Mouse (Murine) Insulin Receptor-Related Receptor (INSRR) interaction partners

The activation of IRR by alkali might be part of a local loop of signaling between the exocrine and endocrine parts of the pancreas where alkalinization of the juice facilitate insulin release that increases the volume of secreted juice to control its pH and bicabonate content.
Disruption of insulin receptor-related receptor in mice impairs the renal response to alkali loading attested by development of metabolic alkalosis and decreased urinary bicarbonate excretion in response to this challenge
the insulin receptor tyrosine kinase family, comprising Ir, Igf1r and Irr, is required for the appearance of male gonads and thus for male sexual differentiation
Insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) were targeted and compared as central distributors of the insulin signal, the insulin receptor, the insulin-like growth factor 1 receptor, and the insulin receptor-related receptor.

INSRR profil antigène

Antigen Summary

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Alternative names and synonyms associated with INSRR

insulin receptor related receptor (INSRR) anticorps
insulin receptor-related receptor (Insrr) anticorps
insulin receptor related receptor L homeolog (insrr.L) anticorps
insulin receptor related receptor (insrr) anticorps
insulin receptor related receptor (Insrr) anticorps

INSRR anticorps
Irr anticorps
MGC68585 anticorps
Sirr anticorps

Protein level used designations for INSRR

IR-related receptor , insulin receptor-related protein , IRR , insulin receptor-related receptor , insulin receptor-related protein-like

GENE ID	SPECIES
3645	Homo sapiens
23920	Mus musculus
60663	Rattus norvegicus
398941	Xenopus laevis
490405	Canis lupus familiaris
718670	Macaca mulatta
787068	Bos taurus
100338576	Oryctolagus cuniculus
100023690	Monodelphis domestica
100490498	Xenopus (Silurana) tropicalis
100556999	Anolis carolinensis
100716566	Cavia porcellus
100155702	Sus scrofa

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Show all anti-Insulin Receptor-Related Receptor (INSRR) Anticorps with Pubmed References

Human Insulin Receptor-Related Receptor (INSRR) interaction partners

Mouse (Murine) Insulin Receptor-Related Receptor (INSRR) interaction partners

Antigen Summary

Alternative names and synonyms associated with INSRR

Protein level used designations for INSRR